Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marco Pirazzi"'
Autor:
Martina Baraldo, Alessia Geremia, Marco Pirazzini, Leonardo Nogara, Francesca Solagna, Clara Türk, Hendrik Nolte, Vanina Romanello, Aram Megighian, Simona Boncompagni, Marcus Kruger, Marco Sandri, Bert Blaauw
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 208-225 (2020)
Abstract Background Skeletal muscle is a plastic tissue that can adapt to different stimuli. It is well established that Mammalian Target of Rapamycin Complex 1 (mTORC1) signalling is a key modulator in mediating increases in skeletal muscle mass and
Externí odkaz:
https://doaj.org/article/5034fd17f0124217ab6feff1168397f9
Autor:
Elisa Duregotti, Giulia Zanetti, Michele Scorzeto, Aram Megighian, Cesare Montecucco, Marco Pirazzini, Michela Rigoni
Publikováno v:
Toxins, Vol 7, Iss 12, Pp 5322-5336 (2015)
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (β-Bungarotoxin, β-Btx, from elapid snakes and α-Latrotoxin, α-Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes
Externí odkaz:
https://doaj.org/article/b1066d915215496b96a8164a96602922
Autor:
Marco Pirazzini, Domenico Azarnia Tehran, Giulia Zanetti, Aram Megighian, Michele Scorzeto, Silvia Fillo, Clifford C. Shone, Thomas Binz, Ornella Rossetto, Florigio Lista, Cesare Montecucco
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1870-1878 (2014)
Botulinum neurotoxins consist of a metalloprotease linked via a conserved interchain disulfide bond to a heavy chain responsible for neurospecific binding and translocation of the enzymatic domain in the nerve terminal cytosol. The metalloprotease ac
Externí odkaz:
https://doaj.org/article/2b65ebbe911044068d24c51c7fcb1948
Autor:
Bazbek Davletov, Giampietro Schiavo, Dhevahi Niranjan, Ornella Rossetto, Michael H. Hastings, Marco Pirazzini, Matteo Caleo, Enrico Ferrari, Elizabeth S. Maywood, Laura Restani
Publikováno v:
Toxins, Vol 3, Iss 4, Pp 345-355 (2011)
The therapeutic potential of botulinum neurotoxin type A (BoNT/A) has recently been widely recognized. BoNT/A acts to silence synaptic transmission via specific proteolytic cleavage of an essential neuronal protein, SNAP25. The advantages of BoNT/A-m
Externí odkaz:
https://doaj.org/article/c84a573ae46d42cab09b9f4d227c36c6
Autor:
Luca Bano, Elena Tonon, Ilenia Drigo, Marco Pirazzini, Angela Guolo, Giovanni Farina, Fabrizio Agnoletti, Cesare Montecucco
Publikováno v:
Toxins, Vol 10, Iss 6, p 248 (2018)
The presence of botulinum neurotoxin-producing Clostridia (BPC) in food sources is a public health concern. In favorable environmental conditions, BPC can produce botulinum neurotoxins (BoNTs) outside or inside the vertebrate host, leading to intoxic
Externí odkaz:
https://doaj.org/article/8c2112fd6a1e4981a046bdde23bd077a
Publikováno v:
Toxins, Vol 10, Iss 5, p 190 (2018)
Botulinum neurotoxins (BoNTs), the etiological agents of botulism, are the deadliest toxins known to humans. Yet, thanks to their biological and toxicological features, BoNTs have become sophisticated tools to study neuronal physiology and valuable t
Externí odkaz:
https://doaj.org/article/c77c0e00dd324f429cf1ded73b2000ef
Publikováno v:
Toxins, Vol 9, Iss 12, p 404 (2017)
The Genome Aggregation Database presently contains >120,000 human genomes. We searched in this database for the presence of mutations at the sites of tetanus (TeNT) and botulinum neurotoxins (BoNTs) cleavages of the three SNARE proteins: VAMP, SNAP-2
Externí odkaz:
https://doaj.org/article/331b7f78f1894972a1194ced01a71f17
Autor:
Michael W. Peck, Theresa J. Smith, Fabrizio Anniballi, John W. Austin, Luca Bano, Marite Bradshaw, Paula Cuervo, Luisa W. Cheng, Yagmur Derman, Brigitte G. Dorner, Audrey Fisher, Karen K. Hill, Suzanne R. Kalb, Hannu Korkeala, Miia Lindström, Florigio Lista, Carolina Lúquez, Christelle Mazuet, Marco Pirazzini, Michel R. Popoff, Ornella Rossetto, Andreas Rummel, Dorothea Sesardic, Bal Ram Singh, Sandra C. Stringer
Publikováno v:
Toxins, Vol 9, Iss 1, p 38 (2017)
Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which pre
Externí odkaz:
https://doaj.org/article/98919fbc4fc146f884f461918e1dbd37
Publikováno v:
Proceedings of the 8th International Conference on Internet of Things, Big Data and Security.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1a9e5c7e021300f26d8d4c5271503ed
https://doi.org/10.5220/0011918700003482
https://doi.org/10.5220/0011918700003482
Autor:
Oneda Leka, Yufan Wu, Giulia Zanetti, Sven Furler, Thomas Reinberg, Joana Marinho, Jonas V. Schaefer, Andreas Plückthun, Xiaodan Li, Marco Pirazzini, Richard A. Kammerer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract In this study, we characterize Designed Ankyrin Repeat Proteins (DARPins) as investigative tools to probe botulinum neurotoxin A1 (BoNT/A1) structure and function. We identify DARPin-F5 that completely blocks SNAP25 substrate cleavage by BoN
Externí odkaz:
https://doaj.org/article/2e37d6fe1358488f9b33242c875dd948