Zobrazeno 1 - 10
of 334
pro vyhledávání: '"Marco Pappagallo"'
Autor:
Franz Gross, Eberhard Klempt, Stanley J. Brodsky, Andrzej J. Buras, Volker D. Burkert, Gudrun Heinrich, Karl Jakobs, Curtis A. Meyer, Kostas Orginos, Michael Strickland, Johanna Stachel, Giulia Zanderighi, Nora Brambilla, Peter Braun-Munzinger, Daniel Britzger, Simon Capstick, Tom Cohen, Volker Crede, Martha Constantinou, Christine Davies, Luigi Del Debbio, Achim Denig, Carleton DeTar, Alexandre Deur, Yuri Dokshitzer, Hans Günter Dosch, Jozef Dudek, Monica Dunford, Evgeny Epelbaum, Miguel A. Escobedo, Harald Fritzsch, Kenji Fukushima, Paolo Gambino, Dag Gillberg, Steven Gottlieb, Per Grafstrom, Massimiliano Grazzini, Boris Grube, Alexey Guskov, Toru Iijima, Xiangdong Ji, Frithjof Karsch, Stefan Kluth, John B. Kogut, Frank Krauss, Shunzo Kumano, Derek Leinweber, Heinrich Leutwyler, Hai-Bo Li, Yang Li, Bogdan Malaescu, Chiara Mariotti, Pieter Maris, Simone Marzani, Wally Melnitchouk, Johan Messchendorp, Harvey Meyer, Ryan Edward Mitchell, Chandan Mondal, Frank Nerling, Sebastian Neubert, Marco Pappagallo, Saori Pastore, José R. Peláez, Andrew Puckett, Jianwei Qiu, Klaus Rabbertz, Alberto Ramos, Patrizia Rossi, Anar Rustamov, Andreas Schäfer, Stefan Scherer, Matthias Schindler, Steven Schramm, Mikhail Shifman, Edward Shuryak, Torbjörn Sjöstrand, George Sterman, Iain W. Stewart, Joachim Stroth, Eric Swanson, Guy F. de Téramond, Ulrike Thoma, Antonio Vairo, Danny van Dyk, James Vary, Javier Virto, Marcel Vos, Christian Weiss, Markus Wobisch, Sau Lan Wu, Christopher Young, Feng Yuan, Xingbo Zhao, Xiaorong Zhou
Publikováno v:
European Physical Journal C: Particles and Fields, Vol 83, Iss 12, Pp 1-636 (2023)
Abstract Quantum Chromodynamics, the theory of quarks and gluons, whose interactions can be described by a local SU(3) gauge symmetry with charges called “color quantum numbers”, is reviewed; the goal of this review is to provide advanced Ph.D. s
Externí odkaz:
https://doaj.org/article/8dbfcd189124442ba3cab54901df35f3
Autor:
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Franco Folli, Marco Pappagallo, Cedric O’Gorman, Clotilde Guidetti, Andrea Mattarei, Charles E. Inturrisi, Paolo L. Manfredi
Publikováno v:
Drugs in R&D, Vol 24, Iss 1, Pp 51-68 (2023)
Abstract Background and Objective Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone. Esmethadone is a low potency N-methyl-D-aspartate (NMDA) receptor channel blo
Externí odkaz:
https://doaj.org/article/9a07ec79820f4842b2bf83183c3444df
Autor:
Megan J. Shram, Jack E. Henningfield, Glen Apseloff, Charles W. Gorodetzky, Sara De Martin, Frank L. Vocci, Frank L. Sapienza, Thomas R. Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O’Gorman, Sergio Traversa, Charles E. Inturrisi, Paolo L. Manfredi, Marco Pappagallo
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robu
Externí odkaz:
https://doaj.org/article/b958bfa2946e4409a7e15362350d0462
Autor:
Jack Henningfield, David Gauvin, Francesco Bifari, Reginald Fant, Megan Shram, August Buchhalter, Judy Ashworth, Ryan Lanier, Marco Pappagallo, Charles Inturrisi, Franco Folli, Sergio Traversa, Paolo L. Manfredi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract REL-1017 (esmethadone, d-methadone) is the opioid-inactive d-isomer of racemic d,l-methadone. REL-1017 may exert antidepressant effects via uncompetitive N-methyl-d-aspartate receptor (NMDAR) channel block. As REL-1017 is expected to exert c
Externí odkaz:
https://doaj.org/article/af8fabe8ee0d48f4ab00370a37dd858f
Autor:
Francesco Bifari, Marco Pappagallo, Michael Bleavins, Sergio Traversa, Franco Folli, Paolo L. Manfredi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
REL-1017 (esmethadone; dextromethadone; (S)-methadone) is the opioid-inactive dextro-isomer of the racemic mixture, (R, S)-methadone. REL-1017 acts as a low affinity, low potency N-methyl-D-aspartate receptor (NMDAR) channel blocker with rapid, robus
Externí odkaz:
https://doaj.org/article/c8b0beaef641458ca60f25965e8c4aa2
Autor:
Stephen M. Stahl, Sara De Martin, Andrea Mattarei, Ezio Bettini, Luca Pani, Clotilde Guidetti, Franco Folli, Marc de Somer, Sergio Traversa, Charles E. Inturrisi, Marco Pappagallo, Marco Gentilucci, Andrea Alimonti, Maurizio Fava, Paolo L. Manfredi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12196 (2022)
This article presents a mechanism of action hypothesis to explain the rapid antidepressant effects of esmethadone (REL-1017) and other uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists and presents a corresponding mechanism of disease h
Externí odkaz:
https://doaj.org/article/3a4d6b056c8344ba9d20f96240da3031
Autor:
Ezio Bettini, Stephen M. Stahl, Sara De Martin, Andrea Mattarei, Jacopo Sgrignani, Corrado Carignani, Selena Nola, Patrizia Locatelli, Marco Pappagallo, Charles E. Inturrisi, Francesco Bifari, Andrea Cavalli, Andrea Alimonti, Luca Pani, Maurizio Fava, Sergio Traversa, Franco Folli, Paolo L. Manfredi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 997 (2022)
Excessive Ca2+ currents via N-methyl-D-aspartate receptors (NMDARs) have been implicated in many disorders. Uncompetitive NMDAR channel blockers are an emerging class of drugs in clinical use for major depressive disorder (MDD) and other neuropsychia
Externí odkaz:
https://doaj.org/article/a9489daf59de4062bfa561e5de1336f9
Autor:
Ezio Bettini, Sara De Martin, Andrea Mattarei, Marco Pappagallo, Stephen M. Stahl, Francesco Bifari, Charles E. Inturrisi, Franco Folli, Sergio Traversa, Paolo L. Manfredi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 882 (2022)
REL-1017 (esmethadone) is a novel N-methyl-D-aspartate receptor (NMDAR) antagonist and promising rapid antidepressant candidate. Using fluorometric imaging plate reader (FLIPR) assays, we studied the effects of quinolinic acid (QA) and gentamicin, wi
Externí odkaz:
https://doaj.org/article/790f963de6d14b359c5bec9f2fbe1fc3
Autor:
Sara De Martin, Daniela Gabbia, Franco Folli, Francesco Bifari, Paolo Fiorina, Nicola Ferri, Stephen Stahl, Charles E. Inturrisi, Marco Pappagallo, Sergio Traversa, Paolo L. Manfredi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Brain-derived neurotrophic factor (BDNF), a neurotrophin widely expressed in the central nervous system, exhibits important effects on neural plasticity. BDNF has been implicated in the mechanism of action of ketamine, a N-methyl-d-aspartic acid rece
Externí odkaz:
https://doaj.org/article/bc0cdc1dafc040f7ae823a00bba8a45f
Publikováno v:
The Scientific World Journal, Vol 8, Pp 229-236 (2008)
Neuropathic pain is a sequela of dysfunction, injuries, or diseases of the peripheral and/or central nervous system pain pathways, which has historically been extremely difficult to treat. Complex regional pain syndrome (CRPS) types 1 and 2 are neuro
Externí odkaz:
https://doaj.org/article/0765a1f7cf0e499f9c0f3ea70683dd25