Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure

Autor: Michele Ciccarelli, Daniela Sorriento, Antonella Fiordelisi, Jessica Gambardella, Antonietta Franco, Carmine delGiudice, Marina Sala, Maria Gaia Monti, Alessia Bertamino, Pietro Campiglia, Marco Oliveti, Paolo Poggio, Giovanna Trinchese, Gina Cavaliere, Ersilia Cipolletta, Maria Pina Mollica, Domenico Bonaduce, Bruno Trimarco, Guido Iaccarino

Publikováno v: ESC Heart Failure, Vol 7, Iss 4, Pp 1571-1584 (2020)

Abstract Aims The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functiona

Externí odkaz: https://doaj.org/article/e81b5044fb7e45569835835d35abf720

New Nutraceutical Combination Reduces Blood Pressure and Improves Exercise Capacity in Hypertensive Patients Via a Nitric Oxide–Dependent Mechanism

Autor: Albino Carrizzo, Ornella Moltedo, Antonio Damato, Katiuscia Martinello, Paola Di Pietro, Marco Oliveti, Fausto Acernese, Giuseppe Giugliano, Raffaele Izzo, Eduardo Sommella, Serena Migliarino, Ornella Piazza, Carmine Izzo, Nicola Virtuoso, Andrea Strianese, Valentina Trimarco, Pietro Campiglia, Sergio Fucile, Annibale Puca, Bruno Trimarco, Carmine Vecchione

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 5 (2020)

Background High blood pressure (BP) has long been recognized as a major health threat and, particularly, a major risk factor for stroke, cardiovascular disease, and end‐organ damage. However, the identification of a novel, alternative, integrative

Externí odkaz: https://doaj.org/article/9fe744bcee0046bd8a73009713d1841b

Correction: Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis.

Autor: Gabriele Giacomo Schiattarella, Fabio Cattaneo, Gianluigi Pironti, Fabio Magliulo, Giuseppe Carotenuto, Marinella Pirozzi, Roman Polishchuk, Domenica Borzacchiello, Roberta Paolillo, Marco Oliveti, Nicola Boccella, Marisa Avvedimento, Maria Sepe, Giuseppe Gargiulo, Assunta Lombardi, Rosa Anna Busiello, Bruno Trimarco, Giovanni Esposito, Antonio Feliciello, Cinzia Perrino

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0158934 (2016)

[This corrects the article DOI: 10.1371/journal.pone.0154076.].

Externí odkaz: https://doaj.org/article/f57b3d87c79e482cbe963c8abb77ba47

Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Autor: Michele Ciccarelli, Evangelos P. Daskalopoulos, Luc Bertrand, Mauro Giacca, Florian Leuschner, Matteo Dal Ferro, Emilio Hirsch, Manuel Mayr, James Cimino, Michele Russo, Wolfgang A. Linke, Christophe Beauloye, André P. Lourenço, Antonio Cannatà, Lucie Carrier, Johannes Backs, Inês Falcão-Pires, Nazha Hamdani, Alessia Paldino, Pierluigi Lesizza, Florian Weinberger, Bruno Pinamonti, Serena Zacchigna, Dana Dawson, Ilona Cuijpers, Gianfranco Sinagra, Marco Oliveti, Diederik W. D. Kuster, Izhak Kehat, Stephane Heymans, Simone Vodret, Martine de Boer, Thomas Eschenhagen, Carlo G. Tocchetti, Alessandra Ghigo, Dirk J. Duncker, Jolanda van der Velden, Daniela Miranda-Silva, Thomas Thum

Publikováno v: Cardiovascular Research
Cardiovascular research, Vol. 117, no. 1, p. 43-59 (2021)
Zacchigna, S, Paldino, A, Falcão-Pires, I, Daskalopoulos, E P, Dal Ferro, M, Vodret, S, Lesizza, P, Cannatà, A, Miranda-Silva, D, Lourenço, A P, Pinamonti, B, Sinagra, G, Weinberger, F, Eschenhagen, T, Carrier, L, Kehat, I, Tocchetti, C G, Russo, M, Ghigo, A, Cimino, J, Hirsch, E, Dawson, D, Ciccarelli, M, Oliveti, M, Linke, W A, Cuijpers, I, Heymans, S, Hamdani, N, De Boer, M, Duncker, D J, Kuster, D, Van Der Velden, J, Beauloye, C, Bertrand, L, Mayr, M, Giacca, M, Leuschner, F, Backs, J & Thum, T 2021, ' Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents : A position paper of the ESC Working Group on Myocardial Function ', Cardiovascular Research, vol. 117, no. 1, pp. 43-59 . https://doi.org/10.1093/cvr/cvaa110

Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79d35e31010aca435b4f9af28cb0743

Role of Endothelial G Protein-Coupled Receptor Kinase-2 in Angioedema

Autor: Stefania Loffredo, Maria Bova, Jessica Gambardella, Xujun Wang, Gaetano Santulli, Michele Ciccarelli, Guido Iaccarino, Bruno Trimarco, Mariarosaria Rusciano, Angelica Petraroli, Giuseppe Spadaro, Laura Carucci, Marco Bruno Morelli, Antonella Fiordelisi, Pietro Campiglia, Ilaria Mormile, Marina Sala, Daniela Sorriento, Marco Oliveti

Publikováno v: Hypertension

Excessive BK (bradykinin) stimulation is responsible for the exaggerated permeabilization of the endothelium in angioedema. However, the molecular mechanisms underlying these responses have not been investigated. BK receptors are Gq-protein-coupled r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c0666b33d3cbd8bc2c908630bb70ef
https://europepmc.org/articles/PMC7544666/