Mitotic DNA damage promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells

Autor: Marco Novais-Cruz, António Pombinho, Mafalda Sousa, André F. Maia, Helder Maiato, Cristina Ferrás

Publikováno v: Mol Biol Cell

DNA damage response (DDR) during interphase involves active signalling and repair to ensure genomic stability. However, how mitotic cells respond to DNA damage remains poorly understood. Supported by correlative live-/fixed-cell microscopy we found t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dba7b6ccb6b6b485f12ab0602245ce
https://europepmc.org/articles/PMC7614429/

Long-term mitotic DNA damage promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells

Autor: Marco Novais-Cruz, António Pombinho, Mafalda Sousa, André F. Maia, Helder Maiato, Cristina Ferrás

DNA damage response (DDR) during interphase involves active signalling and repair to ensure genomic stability. However, how mitotic cells respond to DNA damage remains poorly understood. Supported by correlative live-/fixed-cell microscopy analysis w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dc4f69040a97b3fda531d5a98e8021c
https://doi.org/10.1101/2022.07.22.501103

Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells

Autor: Ana Margarida, Gomes, Bernardo, Orr, Marco, Novais-Cruz, Filipe, De Sousa, Joana, Macário-Monteiro, Carolina, Lemos, Cristina, Ferrás, Helder, Maiato

Publikováno v: Current Biology

Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly supervised by the spindle assembly checkpoint (SAC) as a byproduct of ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d52ae4acea36cb221f83fa6f85448be
https://doi.org/10.1016/j.cub.2022.08.026

Coherent-hybrid STED: a tunable photo-physical pinhole for super-resolution imaging at high contrast

Autor: Ana C Almeida, Marco Novais-Cruz, António J. Pereira, Mafalda Sousa, Helder Maiato, Paula Sampaio, Luísa T. Ferreira, Ana Costa, Michael Belsley, Mónica Sousa, Cristina Ferrás

Resolution in microscopy is not limited by diffraction as long as a nonlinear sample response is exploited. In a paradigmatic example, stimulated-emission depletion (STED) fluorescence microscopy fundamentally ‘breaks’ the diffraction limit by us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f31d99d588760bfa8701a8f88152690

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

Autor: Wilfred F. J. van IJcken, Helder Maiato, Maria Alba Fernandez, Marco Novais-Cruz, Cristina Ferrás, Niels Galjart, A. Arockia Jeyaprakash

Publikováno v: eLife
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Novais-Cruz, M, Abad, M A, van IJcken, W F J, Galjart, N, Jeyaprakash, A A, Maiato, H & Ferrás, C 2018, ' Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription ', eLIFE, vol. 7, e36898 . https://doi.org/10.7554/eLife.36898
eLife, Vol 7 (2018)
eLife, 7:e36898. eLife Sciences Publications

Recent studies have challenged the prevailing dogma that transcription is repressed during mitosis. Transcription was also proposed to sustain a robust spindle assembly checkpoint (SAC) response. Here, we used live-cell imaging of human cells, RNA-se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23852947987fa5b68a746d2b6c35c564