Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Marco Muda"'
Antibody-mediated targeting of TNFR2 activates CD8 + T cells in mice and promotes antitumor immunity
Autor:
Wenlian Qiao, James Qiu, James Lulo, Jian Tang, Anne-Sophie Dugast, Ross B. Fulton, Galina Craig, Stephanie Grabow, Maja Razlog, James F. Sampson, Eric M. Tam, Sonia Feau, Alexander Koshkaryev, Neeraj Kohli, Kathy Zhang, Yang Jiao, Lia Luus, Adam Camblin, Jennifer Richards, Christina S. F. Wong, Daryl C. Drummond, James Suchy, Aniela Jakubowski, Michael Croft, Marco Muda, James D. Marks, Elizabeth Hutto, Vinodh B. Kurella, Yu Zhou, Andreas Raue, Hong Zhang, Lihui Xu, Fabien Dépis, Sandeep Kumar, Violette Paragas
Publikováno v:
Science Translational Medicine. 11
Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (Tregs) in autoimm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5923342bbcf0a08d5a53784115771df
https://doi.org/10.1126/scitranslmed.aax0720
https://doi.org/10.1126/scitranslmed.aax0720
Autor:
Eric M, Tam, Ross B, Fulton, James F, Sampson, Marco, Muda, Adam, Camblin, Jennifer, Richards, Alexander, Koshkaryev, Jian, Tang, Vinodh, Kurella, Yang, Jiao, Lihui, Xu, Kathy, Zhang, Neeraj, Kohli, Lia, Luus, Elizabeth, Hutto, Sandeep, Kumar, James, Lulo, Violette, Paragas, Christina, Wong, James, Suchy, Stephanie, Grabow, Anne-Sophie, Dugast, Hong, Zhang, Fabien, Depis, Sonia, Feau, Aniela, Jakubowski, Wenlian, Qiao, Galina, Craig, Maja, Razlog, James, Qiu, Yu, Zhou, James D, Marks, Michael, Croft, Daryl C, Drummond, Andreas, Raue
Publikováno v:
Science translational medicine. 11(512)
Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37f83727e9fb0372906f1265c50b70b8
https://pubmed.ncbi.nlm.nih.gov/31578241
https://pubmed.ncbi.nlm.nih.gov/31578241
Autor:
James F. Sampson, Vinodh B. Kurella, Violette Paragas, Sandeep Kumar, James E. Lulo, James A. Qiu, Maja Razlog, Ross B. Fulton, Adam J. Camblin, Jennifer M. Richards, Christina S. Wong, Alexander Koshkaryev, James J. Suchy, Stephanie Grabow, Marco Muda, Andreas Raue, Daryl C. Drummond, Eric M. Tam
Publikováno v:
Cancer Research. 79:555-555
TNFR2 is an emerging therapeutic target in immuno-oncology. We have previously shown that an agonistic mouse TNFR2 antibody was able to activate CD8+ T cells in vitro and has anti-tumor activity in multiple syngeneic mouse tumor models. This activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c9f14a39bb58f6cf7c277d0e6b2529a
https://doi.org/10.1158/1538-7445.am2019-555
https://doi.org/10.1158/1538-7445.am2019-555
Autor:
Maja Razlog, James F. Sampson, Adam Camblin, Eric M. Tam, Alexander Koshkaryev, Ross B. Fulton, Lia Luus, Christina Wong, Marco Muda, Violette Paragas, Yang Jiao, Lihui Xu, Jennifer Richards, Andreas Raue, Daryl C. Drummond
Publikováno v:
Cancer Research. 79:3270-3270
TNFR2 is a member of the TNF receptor superfamily that is upregulated upon T cell activation and is highly expressed by tumor-infiltrating effector and regulatory T cells. We investigated TNFR2 levels on T cells in syngeneic mouse tumor models and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74f5940c36ebe9991da8b872365d007f
https://doi.org/10.1158/1538-7445.am2019-3270
https://doi.org/10.1158/1538-7445.am2019-3270
Autor:
James F Sampson, Ross B Fulton, Vinodh B Kurella, Jennifer M Richards, Adam J Camblin, Christina S Wong, Alexander Koshkaryev, James E Lulo, James A Qiu, Sandeep Kumar, Lia Luus, Yang Jiao, James Suchy, Stephanie Grabow, Violette Paragas, Maja Razlog, Lihui Xi, Marco Muda, Daryl C Drummond, Eric M Tam, Andreas Raue
Publikováno v:
The Journal of Immunology. 202:195.11-195.11
TNFR2, an emerging therapeutic target in immuno-oncology, is upregulated upon T cell activation and is expressed by tumor-infiltrating effector and regulatory T (Treg) cells. We generated a novel monoclonal antibody, Y9, specific to murine TNFR2 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::624e86a920e0d2baffd92d61cd0d3ecf
https://doi.org/10.4049/jimmunol.202.supp.195.11
https://doi.org/10.4049/jimmunol.202.supp.195.11
Autor:
Cheryl A. Nechamen, Marco Muda, James A. Dias, Stephen S. Palmer, Richard M. Thomas, Joseph E. Mazurkiewicz
Publikováno v:
Endocrinology. 148:1987-1995
FSH receptor (FSHR), a member of the G protein-coupled receptor superfamily, is present in the plasma membrane of ovarian granulosa cells and testicular Sertoli cells. FSH regulates normal ovarian follicle development and spermatogenesis through FSHR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793610e6a95fe7c60b29dac281c9e2b4
https://doi.org/10.1210/en.2006-1672
https://doi.org/10.1210/en.2006-1672
Autor:
Colette Chevrier, Deanne Taylor, Christie A. Kelton, Rene Lynn Schweickhardt, Sharon Layfield, Marco Muda, Paolo Martini, Ross A. D. Bathgate, Peter L. Ryan, Tania Ferraro, Chaomei He
Publikováno v:
MHR: Basic science of reproductive medicine. 11:591-600
LGR7 and LGR8 are G protein-coupled receptors that belong to the leucine-rich repeat-containing G-protein coupled receptor (LGR) family, including the thyroid-stimulating hormone (TSH), LH and FSH receptors. LGR7 and LGR8 stimulate cAMP production up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cafd539ecd70fb1c30cea352901d79
https://doi.org/10.1093/molehr/gah205
https://doi.org/10.1093/molehr/gah205
Publikováno v:
Biochemical Journal. 366:73-77
Despite the wealth of information generated by genome-sequencing projects, the identification of in vivo substrates of specific protein kinases and phosphatases is hampered by the large number of candidate enzymes, overlapping enzyme specificity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70b47527a15f552bb035e6894390244
https://doi.org/10.1042/bj20020298
https://doi.org/10.1042/bj20020298
Autor:
Nancy Simonson-Leff, Marco Muda, James C. Clemens, Carolyn A. Worby, Jack E. Dixon, Donald P. Huddler
Publikováno v:
Journal of Biological Chemistry. 277:9422-9428
Dock, the Drosophila orthologue of Nck, is an adaptor protein that is known to function in axonal guidance paradigms in the fly including proper development of neuronal connections in photoreceptor cells and axonal tracking in Bolwig's organ. To deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8945ba51456f5df446b289709819d198
https://doi.org/10.1074/jbc.m110172200
https://doi.org/10.1074/jbc.m110172200
Autor:
Neeraj Kohli, Dake Tamara, Haluk Yuzugullu, Violette Paragas, Lihui Xu, Greg Finn, Yasmin Hashambhoy-Ramsay, Maja Razlog, Birgit Schoeberl, Charlotte Mcdonagh, Melissa Geddie, Sara Ghassemifar, Marco Muda
Publikováno v:
Cancer Research. 77:22-22
Aberrant signaling of the FGFR pathway has long been known to promote tumorigenesis and angiogenesis across multiple cancer indications. However, the development of an effective and well-tolerated FGFR targeted inhibitor has been hindered by the need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37975d8959833d5a7c00e934f77321c6
https://doi.org/10.1158/1538-7445.am2017-22
https://doi.org/10.1158/1538-7445.am2017-22