Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Marco Mottinelli"'
Autor:
Lisa L. Wilson, Amy R. Alleyne, Shainnel O. Eans, Thomas J. Cirino, Heather M. Stacy, Marco Mottinelli, Sebastiano Intagliata, Christopher R. McCurdy, Jay P. McLaughlin
Publikováno v:
Molecules, Vol 27, Iss 11, p 3617 (2022)
Sigma receptors modulate nociception, offering a potential therapeutic target to treat pain, but relatively little is known regarding the role of sigma-2 receptors (S2R) in nociception. The purpose of this study was to investigate the in vivo analges
Externí odkaz:
https://doaj.org/article/b52e94dd1a3a49688fc681766bfc0bd2
Autor:
David A. Ostrov, Andrew P. Bluhm, Danmeng Li, Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam, Kalpana K. Bhanumathy, Jocelyne Lew, Darryl Falzarano, Franco J. Vizeacoumar, Joyce A. Wilson, Marco Mottinelli, Siva Rama Raju Kanumuri, Abhisheak Sharma, Christopher R. McCurdy, Michael H. Norris
Publikováno v:
Pathogens, Vol 10, Iss 11, p 1514 (2021)
(1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interaction
Externí odkaz:
https://doaj.org/article/63add6fb9ba140d2866daea0ebf129c3
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 1871-1878 (2017)
Background: 1,2,3,4-Tetrahydroisoquinolines (THIQs) are common motifs in alkaloids and in medicinal chemistry. Synthetic access to THIQs via the Pomeranz–Fritsch–Bobbit (PFB) methodology using mineral acids for deactivated, electron-poor aromatic
Externí odkaz:
https://doaj.org/article/a1321fe5e52840bba90ef1c339f7ab6c
Autor:
Thomas J. Cirino, Shainnel O. Eans, Jessica M. Medina, Lisa L. Wilson, Marco Mottinelli, Sebastiano Intagliata, Christopher R. McCurdy, Jay P. McLaughlin
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allody
Externí odkaz:
https://doaj.org/article/3a6d16ca430e49cab94ae69862831961
Autor:
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T. Dang, Larissa C. Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R. McCurdy, Sarah E. O’Connor
Publikováno v:
Journal of the American Chemical Society
Mitragyna speciosa(“Kratom”) is used as a natural remedy for pain and management of opioid dependence. The pharmacological properties of Kratom have been linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3d2974dfda1ffe4598f63db485a349
https://doi.org/10.1021/jacs.2c13644
https://doi.org/10.1021/jacs.2c13644
Autor:
Yuma T. Ortiz, Joshua A. Bilbrey, Jasmine S. Felix, Erik A. Kienegger, Marco Mottinelli, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson
Publikováno v:
Pharmacological Reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0cbd7bf21bf176969434ab85c986043
https://doi.org/10.1007/s43440-023-00498-w
https://doi.org/10.1007/s43440-023-00498-w
Autor:
Shyam H. Kamble, Erin C. Berthold, Siva Rama Raju Kanumuri, Tamara I. King, Michelle A. Kuntz, Francisco León, Marco Mottinelli, Lance R. McMahon, Christopher R. McCurdy, Abhisheak Sharma
Publikováno v:
The AAPS Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccda6d4cc19c400bb1ffe6113bb47dde
https://doi.org/10.1208/s12248-022-00736-8
https://doi.org/10.1208/s12248-022-00736-8
Autor:
Victoria L.C. Pallares, Anna E. Pennington, Morgan L. Crowley, Avi Patel, Morgan E. Reeves, Carolina Lopera-Londoño, Marco Mottinelli, Nicholas P. Ho, Francisco León, John D. Fortner, Christopher R. McCurdy, Luis F. Restrepo, Victoria A. Taylor, Jenny L. Wilkerson, Lance R. McMahon, Samuel Obeng, Takato Hiranita, Tobias Braun, Lea R. Gamez-Jimenez, Morgan R. Williamson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:410-427
Relationships between µ-opioid receptor (MOR) efficacy and effects of mitragynine and 7-hydroxymitragynine are not fully established. We assessed in vitro binding affinity and efficacy and discriminative stimulus effects together with antinociceptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72dcbea9c746af3f998d852e8075016a
https://doi.org/10.1124/jpet.120.000189
https://doi.org/10.1124/jpet.120.000189
Autor:
Takato Hiranita, Julio Zuarth Gonzalez, Rohan C. Patel, Christian C. Mazpule‐Carrigan, Joelma Martins Rocha, Lea R. Gamez Jimenez, Nicholas P. Ho, Avi Patel, Samuel Obeng, Francisco Leon, Marco Mottinelli, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Lance R. McMahon
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ae87d0e1be099e646080afc7b9d48b4
https://doi.org/10.1096/fasebj.2022.36.s1.r5776
https://doi.org/10.1096/fasebj.2022.36.s1.r5776
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce0c9a03b04f0b65b102e007c926d1b
https://doi.org/10.1096/fasebj.2022.36.s1.r2407
https://doi.org/10.1096/fasebj.2022.36.s1.r2407