Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marco Mannes"'
Autor:
Marco Mannes, Rebecca Halbgebauer, Lisa Wohlgemuth, David Alexander Christian Messerer, Susa Savukoski, Anke Schultze, Bettina Berger, Christiane Leonie Knapp, Christoph Q. Schmidt, Daniel Fürst, Morten Hillmer, Reiner Siebert, Oskar Eriksson, Barbro Persson, Bo Nilsson, Kristina Nilsson Ekdahl, Markus Huber-Lang
Publikováno v:
Journal of Innate Immunity, Vol 15, Iss 1, Pp 412-427 (2023)
The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.16
Externí odkaz:
https://doaj.org/article/62eadcbb7b1441f18d52e79ef47787c9
Autor:
Doreen Tabea Spiegelburg, Marco Mannes, Anke Schultze, Frieder Scheibenberger, Frederik Müller, Amadeo Klitzing, David Alexander Christian Messerer, Kristina Nilsson Ekdahl, Bo Nilsson, Markus Huber-Lang, Christian Karl Braun
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280069 (2023)
BackgroundSurface compatibility with blood is critical both for scientific investigations on hemostasis and clinical applications. Regarding in vitro and ex vivo investigations, minimal alteration in physiological hemostasis is of particular importan
Externí odkaz:
https://doaj.org/article/580d7c3af87646e39c9354214aea2fe6
Autor:
Lisa Wohlgemuth, Alexander Elias Paul Stratmann, Frederik Münnich, Stefan Bernhard, Bertram Dietrich Thomaß, Finn Münnich, Adam Omar Khalaf Mohamed, Marco Mannes, Christoph Quirin Schmidt, Kristina Nilsson Ekdahl, Bo Nilsson, Michael Fauler, Karl Josef Föhr, Markus Huber-Lang, David Alexander Christian Messerer
Publikováno v:
Cells, Vol 11, Iss 20, p 3297 (2022)
The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors. However, a comparative systematic analysis of the early impact of key soluble complement cleavage pr
Externí odkaz:
https://doaj.org/article/db36629063ec4c59a107324e29498e2a
Autor:
Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remo
Externí odkaz:
https://doaj.org/article/b93f354ac6754ce79b8066b0a202bbc6
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The alternative pathway regulator Factor H-like protein 1 (FHL-1) is composed of the first 7 N-terminal complement control protein domains of Factor H (FH) and protects host surfaces from uncontrolled complement attack. Although FHL-1 shares the N-te
Externí odkaz:
https://doaj.org/article/b32ca20a70e6450e9493985d6e27eacb
Autor:
Alexander Elias Paul Stratmann, Lisa Wohlgemuth, Maike Elisabeth Erber, Stefan Bernhard, Stefan Hug, Michael Fauler, Laura Vidoni, Adam Omar Khalaf Mohamed, Bertram Dietrich Thomaß, Frederik Münnich, Laura Stukan, Karl Josef Föhr, Marco Mannes, Markus Stefan Huber-Lang, David Alexander Christian Messerer
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1504 (2021)
Neutrophils provide rapid and efficient defense mechanisms against invading pathogens. Upon stimulation with proinflammatory mediators, including complement factors and bacterial peptides, neutrophils respond with changes in their membrane potential,
Externí odkaz:
https://doaj.org/article/d686275d19eb4ea392ad8bb551c7eabe
Autor:
Kristina N. Ekdahl, Karin Fromell, Marco Mannes, Karl‐Henrik Grinnemo, Markus Huber‐Lang, Yuji Teramura, Bo Nilsson
Publikováno v:
Immunological reviewsREFERENCES.
A number of clinical treatment modalities involve contact between blood and biomaterials: these include extracorporeal circuits such as hemodialysis, cardiopulmonary bypass, plasmapheresis, and intravascular treatments. Common side effects arising fr
Autor:
Marco Mannes, Dimitrios C. Mastellos, Kristina N. Ekdahl, Bo Nilsson, Despina Yancopoulou, John D. Lambris, Markus Huber-Lang
Publikováno v:
Seminars in immunology.
Patients in the intensive care unit (ICU) often straddle the divide between life and death. Understanding the complex underlying pathomechanisms relevant to such situations may help intensivists select broadly acting treatment options that can improv
Autor:
Christoph Q. Schmidt, Christian Karl Braun, Markus Huber-Lang, Arne Skerra, Marco Mannes, Hubert Schrezenmeier, Britta Höchsmann, Arthur Dopler, Sophia J. Lang, Rebecca Halbgebauer, Oliver Zolk
Publikováno v:
Blood. 137:443-455
Blocking the terminal complement pathway with the C5 inhibitor eculizumab has revolutionized the clinical management of several complement-mediated diseases and has boosted the clinical development of new inhibitors. Data on the C3 inhibitor Compstat
Publikováno v:
British Journal of Pharmacology. 178:2863-2879
Physical trauma represents a major global burden. The trauma-induced response, including activation of the innate immune system, strives for regeneration but can also lead to post-traumatic complications. The complement cascade is rapidly activated b