Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marco M. Kessler"'
Autor:
Inmaculada Silos-Santiago, Pei Ge, Alexander P. Bryant, Currie Mark G, Caroline B. Kurtz, Sara R. Thomas, Angelika Fretzen, Derek Wachtel, Boris Tchernychev, Robert M. Solinga, Gerhard Hannig, Jenny V. Tobin, Craig E. Lunte, Marco M. Kessler
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 355:48-56
MRP4 mediates the efflux of cGMP and cAMP and acts as an important regulator of these secondary messengers, thereby affecting signaling events mediated by cGMP and cAMP. Immunofluorescence staining showed high MRP4 expression localized predominantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437eae29a0f2545dd978f28834a1f9a4
https://doi.org/10.1124/jpet.115.224329
https://doi.org/10.1124/jpet.115.224329
Autor:
Heming Xing, Bruce Rogers, Guillaume Cottarel, Kim Fechtel, Keith Weinstock, Christine Alberti-Segui, Debra Aker Willins, Arturo J. Morales, Marco M. Kessler
Publikováno v:
Yeast. 21:285-302
Cell-surface proteins are attractive targets for the development of novel antifungals as they are more accessible to drugs than are intracellular targets. By using a computational biology approach, we identified 180 potential cell-surface proteins in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a36cf0f9b0fc92d38abcb1edb569b6
https://doi.org/10.1002/yea.1061
https://doi.org/10.1002/yea.1061
Autor:
Lynn Doucette-Stamm, Roberta S. Hare, Jonathan R. Greene, Qiandong Zeng, Hongmei Lee, Terri McClanahan, Guillaume Cottarel, Richard G Del Mastro, George H. Shimer, Anne Caron, Luquan Wang, Robin Cook, Marco M. Kessler, Debra Aker Willins
Publikováno v:
Fungal Genetics and Biology. 36:59-70
Aspergillus fumigatus is one of the causes of invasive lung disease in immunocompromised individuals. To rapidly identify genes in this fungus, including potential targets for chemotherapy, diagnostics, and vaccine development, we constructed cDNA li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b043211390e7dd42ea946eafe85a7cd
https://doi.org/10.1016/s1087-1845(02)00002-6
https://doi.org/10.1016/s1087-1845(02)00002-6
Autor:
Michael F. Henry, Jing Zhao, Claire Moore, Elisa Shen, Marco M. Kessler, Pamela A. Silver, Stefan Gross
Publikováno v:
Genes & Development. 11:2545-2556
In yeast, four factors (CF I, CF II, PF I, and PAP) are required for accurate pre-mRNA cleavage and polyadenylation in vitro. CF I can be separated further into CF IA and CF IB. Here we show that CF IB is the 73-kD Hrp1 protein. Recombinant Hrp1p mad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec376daa9e1446d3dc264201330a1dc
https://doi.org/10.1101/gad.11.19.2545
https://doi.org/10.1101/gad.11.19.2545
Publikováno v:
Journal of Biological Chemistry. 272:10831-10838
Cleavage of pre-mRNA during 3′-end formation in yeast requires two protein factors, cleavage factor I (CF I) and cleavage factor (CF II). A 5300-fold purification of CF II indicates that four polypeptides of 150, 105, 100, and 90 kDa copurify with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb52e729ae681aa2e942167d353b2a2f
https://doi.org/10.1074/jbc.272.16.10831
https://doi.org/10.1074/jbc.272.16.10831
Publikováno v:
Journal of Biological Chemistry. 271:27167-27175
The cleavage/polyadenylation factor I (CF I) is one of four factors required for mRNA 3′ end formation in the yeast Saccharomyces cerevisiae. Here we describe the purification of CF I and its separation into two components, CF IA and CF IB. Both co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ac5c8fbf9bb6d3c59b1553abc62856
https://doi.org/10.1074/jbc.271.43.27167
https://doi.org/10.1074/jbc.271.43.27167
Publikováno v:
Journal of Biological Chemistry. 270:26715-26720
We have constructed deletions in the nonconserved regions at the amino and carboxyl ends of the poly(A) polymerase (PAP) of Saccharomyces cerevisiae and examined the effects of these truncations on function of the enzyme. PAP synthesizes a poly(A) ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55b7f3277b72bd995cc0b4c12ef0e517
https://doi.org/10.1074/jbc.270.44.26715
https://doi.org/10.1074/jbc.270.44.26715
Autor:
Sarah Hogan, Marco M. Kessler, Qiandong Zeng, Robin Cook, Arturo J. Morales, Guillaume Cottarel
We used genome-wide comparative analysis of predicted protein sequences to identify many novel small genes, named smORFs forsmall open readingframes, within the budding yeast genome. Further analysis of 117 of these new genes showed that 84 are trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a37f4498d8069f7759a485e6037f879
https://europepmc.org/articles/PMC420365/
https://europepmc.org/articles/PMC420365/
Publikováno v:
Current pharmaceutical design. 8(13)
The use of genomics tools to discover new genes, to decipher pathways or to assign a function to a gene is just beginning to have an impact. Genomics approaches have been applied to both antibacterial and antifungal target discovery in order to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10ac8107b01a018a71398f6d640cfab
https://pubmed.ncbi.nlm.nih.gov/12052224
https://pubmed.ncbi.nlm.nih.gov/12052224
Publikováno v:
Molecular and cellular biology. 19(11)
CF II, a factor required for cleavage of the 3* ends of mRNA precursor in Saccharomyces cerevisiae, has been shown to contain four polypeptides. The three largest subunits, Cft1/Yhh1, Cft2/Ydh1, and Brr5/Ysh1, are homologs of the three largest subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb2ba89f5663bdc2b0318307f55cb2d
https://pubmed.ncbi.nlm.nih.gov/10523662
https://pubmed.ncbi.nlm.nih.gov/10523662