Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Marco M. Domingues"'
Autor:
Marcin Makowski, Víctor G. Almendro-Vedia, Marco M. Domingues, Octavio L. Franco, Iván López-Montero, Manuel N. Melo, Nuno C. Santos
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107004- (2023)
Summary: Most antimicrobial peptides (AMPs) exert their microbicidal activity through membrane permeabilization. The designed AMP EcDBS1R4 has a cryptic mechanism of action involving the membrane hyperpolarization of Escherichia coli, suggesting that
Externí odkaz:
https://doaj.org/article/2247f1adf24e487b88399742389a6094
Autor:
Luís Borges-Araújo, Marco M. Domingues, Alexander Fedorov, Nuno C. Santos, Manuel N. Melo, Fábio Fernandes
Publikováno v:
Communications Chemistry, Vol 4, Iss 1, Pp 1-13 (2021)
Phosphatidylinositol-4,5-bisphosphates are involved in membrane regulation and signalling in eukaryotes, with the distribution of acyl chains changing in response to stimuli. Here, molecular dynamics simulations and fluorescence spectroscopy experime
Externí odkaz:
https://doaj.org/article/7cb771ce4cc0462db82f85b499a4dd47
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Over the years, the scientific importance of nanoparticles for biomedical applications has increased. The high stability and biocompatibility, together with the low toxicity of the nanoparticles developed lead to their use as targeted drug delivery s
Externí odkaz:
https://doaj.org/article/03472c6e1ba2440aac4b2323673c2bd7
Autor:
Susana A. Dias, João M. Freire, Clara Pérez-Peinado, Marco M. Domingues, Diana Gaspar, Nuno Vale, Paula Gomes, David Andreu, Sónia T. Henriques, Miguel A. R. B. Castanho, Ana S. Veiga
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial peptides have been considered potential antibacterial drug leads. Using bioinformatic tools we
Externí odkaz:
https://doaj.org/article/ddd3cdbff5cd442a9799bb89ba0a674e
Autor:
João C Sabino, Madalena R de Almeida, Patrícia L Abreu, Ana M Ferreira, Paulo Caldas, Marco M Domingues, Nuno C Santos, Claus M Azzalin, Ana Rita Grosso, Sérgio Fernandes de Almeida
Publikováno v:
eLife, Vol 11 (2022)
DNA oxidation by ten-eleven translocation (TET) family enzymes is essential for epigenetic reprogramming. The conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) initiates developmental and cell-type-specific transcriptional prog
Externí odkaz:
https://doaj.org/article/69620d7f7791425baa6c07e269b1c53d
Autor:
Helen R McPherson, Cedric Duval, Stephen R Baker, Matthew S Hindle, Lih T Cheah, Nathan L Asquith, Marco M Domingues, Victoria C Ridger, Simon DA Connell, Khalid M Naseem, Helen Philippou, Ramzi A Ajjan, Robert AS Ariëns
Publikováno v:
eLife, Vol 10 (2021)
Fibrinogen is essential for blood coagulation. The C-terminus of the fibrinogen α-chain (αC-region) is composed of an αC-domain and αC-connector. Two recombinant fibrinogen variants (α390 and α220) were produced to investigate the role of subre
Externí odkaz:
https://doaj.org/article/c1db5394e1864b85a4927dd251608dff
Publikováno v:
Annual Review of Biophysics. 51:201-221
Mechanical properties have been extensively studied in pure elastic or viscous materials; however, most biomaterials possess both physical properties in a viscoelastic component. How the biomechanics of a fibrin clot is related to its composition and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98a9ecd5866b3b47e8dd90c59eb72e9
https://doi.org/10.1146/annurev-biophys-111821-072110
https://doi.org/10.1146/annurev-biophys-111821-072110
Autor:
João C Sabino, Madalena R de Almeida, Patrícia L Abreu, Ana M Ferreira, Paulo Caldas, Marco M Domingues, Nuno C Santos, Claus M Azzalin, Ana Rita Grosso, Sérgio Fernandes de Almeida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de6b5d21faf4a2b25201834ee08faef3
https://doi.org/10.7554/elife.69476.sa2
https://doi.org/10.7554/elife.69476.sa2
Autor:
Nathan L. Asquith, Cédric Duval, Artem Zhmurov, Stephen R. Baker, Helen R. McPherson, Marco M. Domingues, Simon D. A. Connell, Valeri Barsegov, Robert A. S. Ariëns
Publikováno v:
Blood advances. 6(13)
Fibrin polymerization involves thrombin-mediated exposure of knobs on one monomer that bind to holes available on another, leading to the formation of fibers. In silico evidence has suggested that the classical A:a knob-hole interaction is enhanced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85be7815baf8d7290513fe26327cc561
https://pubmed.ncbi.nlm.nih.gov/35561308
https://pubmed.ncbi.nlm.nih.gov/35561308
Autor:
Alexander Fedorov, Nuno C. Santos, Luís Borges-Araújo, Marco M. Domingues, Fábio Fernandes, Manuel N. Melo
Publikováno v:
Communications Chemistry, Vol 4, Iss 1, Pp 1-13 (2021)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) plays a critical role in the regulation of various plasma membrane processes and signaling pathways in eukaryotes. A significant amount of cellular resources are spent on maintaining the dominant 1-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f4e937c215a6d12239722ea903b6b9
https://doi.org/10.1038/s42004-021-00603-1
https://doi.org/10.1038/s42004-021-00603-1