Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marco M. Candeias"'
Autor:
Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine availab
Externí odkaz:
https://doaj.org/article/5a2c48021da748188909409721466a55
Autor:
Maria José López-Iniesta, Shrutee N. Parkar, Ana Catarina Ramalho, Rafaela Lacerda, Inês F. Costa, Jingyuan Zhao, Luísa Romão, Marco M. Candeias
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15844 (2022)
p53 is the most commonly mutated gene in human cancers. Two fundamental reasons for this are its long protein isoforms protect from cancer, while its shorter C-terminal isoforms can support cancer and metastasis. Previously, we have shown that the Δ
Externí odkaz:
https://doaj.org/article/422926380403453281d056f73898eb4e
Autor:
Shrutee N. Parkar, Maria José López-Iniesta, Ana Catarina Ramalho, Koto Kimura, Jingyuan Zhao, Filipa da Silva Rita, Luísa Romão, Marco M Candeias
p53is with little doubt one of the most powerful genes in our genome, as it makes growthvsarrest, repairvsreplacement, metabolismvsanabolism, lifevsdeath decisions in the cell. One wrong action and a healthy cell is lost or transforms into cancer. So
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81854d4e3e8d50c1fed7057750ec5aca
https://doi.org/10.1101/2023.04.07.536059
https://doi.org/10.1101/2023.04.07.536059
Autor:
Maria José López-Iniesta, Rafaela Lacerda, Ana Catarina Ramalho, Shrutee N. Parkar, Ana Marques-Ramos, Bruna Pereira, Lina Miyawaki, Jun Fujita, Roman Hrstka, Luísa Romão, Marco M Candeias
p53is the most known and studied tumour suppressor gene. Yet we have recently shown thatp53is also a proto-oncogene, as it encodes the Δ160p53 oncoprotein. Integrated stress response (ISR) is a survival pathway frequently activated in cancers, marke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b348b020483b02b0ece32c349f860411
https://doi.org/10.1101/2023.03.03.531004
https://doi.org/10.1101/2023.03.03.531004
Autor:
Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa
SummaryRibosome biogenesis involves the processing of precursor ribosomal RNAs (pre-rRNAs) and sequential assembly with ribosomal proteins. Here we report that nutrient deprivation severely impairs pre-rRNA processing and leads to the accumulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e4870a7eb9451f853334ddf263914a1
https://doi.org/10.1101/2021.12.03.471189
https://doi.org/10.1101/2021.12.03.471189
Autor:
Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa
Publikováno v:
Nature communications. 13(1)
Ribosome biogenesis is an energetically expensive program that is dictated by nutrient availability. Here we report that nutrient deprivation severely impairs precursor ribosomal RNA (pre-rRNA) processing and leads to the accumulation of unprocessed
Autor:
Dumnoensun Pruksakorn, Luca Lo Piccolo, Marco M. Candeias, Salinee Jantrapirom, Hideki Yoshida, Nut Koonrungsesomboon
Publikováno v:
Wiley interdisciplinary reviews. RNAREFERENCES. 12(6)
In the last decade, an intriguing new paradigm of regulation has emerged in which some transcripts longer than 200 nucleotides and no coding potential, long noncoding RNA (lncRNAs), exhibit the capability to control posttranslational modifications of
Publikováno v:
Advances in experimental medicine and biology. 1157
Throughout evolution, eukaryotic cells have devised different mechanisms to cope with stressful environments. When eukaryotic cells are exposed to stress stimuli, they activate adaptive pathways that allow them to restore cellular homeostasis. Most t
Publikováno v:
EMBO reports. 17:1542-1551
Wild-type p53 functions as a tumour suppressor while mutant p53 possesses oncogenic potential. Until now it remains unclear how a single mutation can transform p53 into a functionally distinct gene harbouring a new set of original cellular roles. Her
Autor:
Rafaela Lacerda, Margaret M. Willcocks, Nicolas Locker, Juliane Menezes, Alexandre Teixeira, Luísa Romão, Ana Marques-Ramos, Marco M. Candeias
Publikováno v:
RNA (New York, N.Y.). 23(11)
The mechanistic/mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that integrates cellular signals from the nutrient and energy status to act, namely, on the protein synthesis machinery. While major advances have emerged reg