Výsledky vyhledávání - "Marco M Z Sharkawi"

Akademický článek

New chemometrics-assisted spectrophotometric methods for simultaneous determination of co-formulated drugs montelukast, rupatadine, and desloratadine in their different dosage combinations

Autor: Marco M. Z. Sharkawi, Nehal F. Farid, Moataz H. Hassan, Said A. Hassan

Publikováno v: BMC Chemistry, Vol 18, Iss 1, Pp 1-14 (2024)

Abstract Two accurate, precise and robust multivariate chemometric methods were developed for the simultaneous determination of montelukast sodium (MON), rupatadine fumarate (RUP) and desloratadine (DES). These methods provide a cost-effective altern

Externí odkaz: https://doaj.org/article/a09e68dae09749fb918af791422dbb6b

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Akademický článek

Chromatographic analysis of triple cough therapy; bromhexine, guaiafenesin and salbutamol and pharmaceutical impurity: in-silico toxicity profile of drug impurity

Autor: Marco M. Z. Sharkawi, Mark T. Safwat, Eglal A. Abdelaleem, Nada S. Abdelwahab

Publikováno v: BMC Chemistry, Vol 18, Iss 1, Pp 1-15 (2024)

Abstract Bromhexine (BR), guaiafenesin (GUF) and salbutamol (SAL) are formulated as Ventocough syrup® (with and without sugar), labeled to contain propyl paraben and sodium benzoate as inactive ingredients. They are used to make coughing more produc

Externí odkaz: https://doaj.org/article/0e12086606544874b4df7415b10b65e8

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Ecofriendly LC-MS/MS and TLC-densitometric methods for simultaneous quantitative assay and monitoring of BEGEV regimen, in vivo pharmacokinetic study application

Autor: Marco M. Z. Sharkawi, Norhan R. Mohamed, Mohammed T. El-Saadi, Noha H. Amin

Publikováno v: Analytical Methods. 15:1016-1027

Two rapid, accurate and ecofriendly chromatographic methods were developed for simultaneous determination of bendamustine, gemcitabine and vinorelbine for the purpose of an in vivo pharmacokinetics study in rats.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8337a290d2a1c7eaafa47bc7b2c8ba9
https://doi.org/10.1039/d3ay00081h

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FDA-Validated Ecofriendly Chromatographic Methods for Simultaneous Determination of Gemcitabine and Sorafenib: Applications to Pharmacokinetics

Autor: Marco M. Z. Sharkawi, Norhan R. Mohamed, Mohammed T. El-Saadi, Noha H. Amin

Publikováno v: Chromatographia. 86:109-123

Combination therapy of gemcitabine and sorafenib is synergistically effective and well tolerated in patients with non-small cell lung cancer (NSCLC). In this study, the pharmacokinetic parameters of both gemcitabine and sorafenib were estimated after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99ab32c8d58ada71ccc3ba21af243422
https://doi.org/10.1007/s10337-022-04232-1

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Determination of Gemcitabine and Sorafenib in Spiked Human Plasma Using Multivariate Model Update Chemometric Methods

Autor: Marco M Z Sharkawi, Norhan R Mohamed, Mohammed T El-Saadi, Noha H Amin

Publikováno v: Journal of AOAC International.

Background Gemcitabine (GEM), a pyrimidine nucleoside, has been used as a first line treatment in non-small cell lung cancer (NSCLC). Sorafenib (SOR), a non-selective multi kinase inhibitor, is used as a chemotherapeutic agent in different types of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4c057fca90986823a910affca54730e
https://doi.org/10.1093/jaoacint/qsad062

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Chromatographic analysis of bromhexine and oxytetracycline residues in milk as a drug analysis medium with greenness profile appraisal

Autor: Marco M. Z. Sharkawi, Mark T. Safwat, Eglal A. Abdelaleem, Nada S. Abdelwahab

Publikováno v: Analytical Methods. 14:4064-4076

Tetracyclines are frequently employed in animal husbandry. Bromhexine is a mucolytic drug that improves the efficacy of tetracyclines. It has been reported that residues of tetracyclines in milk may have negative effects on humans. Two versatile and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e15a897a753d70653283df7d2b0347
https://doi.org/10.1039/d2ay01462a

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Validated green chromatographic methods for determination of amlodipine and celecoxib in presence of methylacetophenone

Autor: Noha H. Amin, Marco M. Z. Sharkawi, Norhan R. Mohamed, Mohammed T. El-Saadi

Publikováno v: Bioanalysis. 13:969-983

Aim: Green, accurate and rapid methods, namely LC–MS/MS and thin layer chromatography-densitometric methods, were developed for determination of amlodipine besylate and celecoxib in presence of its process-related impurities, 4-methylacetophenone i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03efdf3059bfb9af910683611dcc47b2
https://doi.org/10.4155/bio-2021-0040

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Five spectrophotometric methods for simultaneous determination of Amlodipine besylate and celecoxib in presence of its toxic impurity

Autor: Noha H. Amin, Marco M. Z. Sharkawi, Norhan R. Mohamed, Mohammed T. El-Saadi

Publikováno v: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 263

Five simple, selective and accurate spectrophotometric methods have been applied and developed for first time for simultaneous determination of amlodipine besylate (AML) and celecoxib (CEL) in presence of one harmful impurity, 4-methylacetophenone (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fd9b5e26920bbad22998f67768986f
https://pubmed.ncbi.nlm.nih.gov/34273891

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