Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Marco M, Hefti"'
Autor:
Sarah Piel, Meagan J. McManus, Kristina N. Heye, Forrest Beaulieu, Hossein Fazelinia, Joanna I. Janowska, Bryce MacTurk, Jonathan Starr, Hunter Gaudio, Nisha Patel, Marco M. Hefti, Martin E. Smalley, Jordan N. Hook, Neha V. Kohli, James Bruton, Thomas Hallowell, Nile Delso, Anna Roberts, Yuxi Lin, Johannes K. Ehinger, Michael Karlsson, Robert A. Berg, Ryan W. Morgan, Todd J. Kilbaugh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Neurological and cardiac injuries are significant contributors to morbidity and mortality following pediatric in-hospital cardiac arrest (IHCA). Preservation of mitochondrial function may be critical for reducing these injuries. Dimethyl fum
Externí odkaz:
https://doaj.org/article/e97966aa91bd40e285a7c98d147519b0
Autor:
Kumaran Senthil, Abhay Ranganathan, Sarah Piel, Marco M. Hefti, Ron W. Reeder, Matthew P. Kirschen, Jonathan Starr, Sarah Morton, Hunter A. Gaudio, Julia C. Slovis, Jeremy R. Herrmann, Robert A. Berg, Todd J. Kilbaugh, Ryan W. Morgan
Publikováno v:
Resuscitation Plus, Vol 19, Iss , Pp 100726- (2024)
Introduction: Swine exhibit cerebral cortex mitochondrial dysfunction and neuropathologic injury after hypoxic cardiac arrest treated with hemodynamic-directed CPR (HD-CPR) despite normal Cerebral Performance Category scores. We analyzed the temporal
Externí odkaz:
https://doaj.org/article/94a4678169044e63ac5a08f6f6c382e0
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Astrocytic tau aggregates are seen in several primary and secondary tauopathies, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and chronic traumatic encephalopathy (CTE). In all of these diseases, astrocyti
Externí odkaz:
https://doaj.org/article/f997b40e70a74864bbd93431d3ebcc36
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 178-184 (2022)
Transcriptomic investigations of traumatic brain injury (TBI) can give us deep insights into the pathological and compensatory processes post-injury. Thus far, transcriptomic studies in TBI have mostly used microarrays and have focused on rodent mode
Externí odkaz:
https://doaj.org/article/bf1da908014d45eeadf5e939970d1ed1
Autor:
Amy C. Gottschalk, Marco M. Hefti
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Microtubule associated proteins (MAPs), defined as proteins that bind microtubules but are not molecular motors or severing enzymes, play a key role in regulating microtubule stability in neurons. Existing studies of the evolutionary relatio
Externí odkaz:
https://doaj.org/article/ad668f62d2f74cdb994a556519b52901
Publikováno v:
Indian Journal of Pathology and Microbiology, Vol 65, Iss 5, Pp 146-152 (2022)
The COVID-19 pandemic has placed global health care systems under unprecedented strain but has, at the same time, provided a unique opportunity for pathologists to turn autopsy findings into directly actionable insights into patient care. The current
Externí odkaz:
https://doaj.org/article/4a0f758261084a7cb9c463f9717bf83a
Autor:
Takehiko Yamanashi, Takaaki Nagao, Nadia E. Wahba, Pedro S. Marra, Kaitlyn J. Crutchley, Alissa A. Meyer, Ally J. Andreasen, Mandy M. Hellman, Sydney S. Jellison, Christopher G. Hughes, Pratik P. Pandharipande, Matthew A. Howard, III, Hiroto Kawasaki, Masaaki Iwata, Marco M. Hefti, Gen Shinozaki
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The pathophysiological mechanisms of postoperative delirium (POD) are still not clear, and no reliable biomarker is available to differentiate those with and without POD. Pre- and post-surgery blood from epilepsy subjects undergoing neurosur
Externí odkaz:
https://doaj.org/article/8a3abd4453304a7f85d9d7d32ab30baf
Autor:
Kumaran Senthil, Marco M. Hefti, Larry N. Singh, Ryan W. Morgan, Constantine D. Mavroudis, Tiffany Ko, Hunter Gaudio, Vinay M. Nadkarni, Johannes Ehinger, Robert A. Berg, Robert M. Sutton, Francis X. McGowan, Todd J. Kilbaugh
Publikováno v:
Resuscitation Plus, Vol 10, Iss , Pp 100243- (2022)
Objective: The effect of cardiac arrest (CA) on cerebral transcriptomics and metabolomics is unknown. We previously demonstrated hemodynamic-directed CPR (HD-CPR) improves survival with favorable neurologic outcomes versus standard CPR (Std-CPR). We
Externí odkaz:
https://doaj.org/article/62fadec4ab90426db8c5b924e25640c7
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract The Src family non-receptor tyrosine kinase Fyn has been implicated in neurodegeneration of Alzheimer’s disease through interaction with amyloid β (Aβ). However, the role of Fyn in the pathogenesis of primary tauopathies such as FTDP-17,
Externí odkaz:
https://doaj.org/article/486e8d74ab4e474798f42ba0ba2852f6
Autor:
Robin L. Haynes, Hannah C. Kinney, Elisabeth A. Haas, Jhodie R. Duncan, Molly Riehs, Felicia Trachtenberg, Dawna D. Armstrong, Sanda Alexandrescu, Jane B. Cryan, Marco M. Hefti, Henry F. Krous, Richard D. Goldstein, Lynn A. Sleeper
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Sudden infant death syndrome (SIDS) is understood as a syndrome that presents with the common phenotype of sudden death but involves heterogenous biological causes. Many pathological findings have been consistently reported in SIDS, notably in areas
Externí odkaz:
https://doaj.org/article/76eb2a9e71e34ddb9afd8f68db013d59