Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Marco Lodrini"'
Autor:
Karin Schmelz, Joern Toedling, Matt Huska, Maja C. Cwikla, Louisa-Marie Kruetzfeldt, Jutta Proba, Peter F. Ambros, Inge M. Ambros, Sengül Boral, Marco Lodrini, Celine Y. Chen, Martin Burkert, Dennis Guergen, Annabell Szymansky, Kathy Astrahantseff, Annette Kuenkele, Kerstin Haase, Matthias Fischer, Hedwig E. Deubzer, Falk Hertwig, Patrick Hundsdoerfer, Anton G. Henssen, Roland F. Schwarz, Johannes H. Schulte, Angelika Eggert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnost
Externí odkaz:
https://doaj.org/article/2390ab09b04a41c28245bac3ed08f2c9
Autor:
Rocío Chamorro González, Thomas Conrad, Maja C. Stöber, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brückner, Eric van Leen, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E. Stefanova, King L. Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y. Chang, Hedwig E. Deubzer, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here we describe single-cell extrachromosomal circular DNA and transcriptome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc99ed2c6257eafccfbc8313ccf81a41
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
Publikováno v:
Cancer Discov
Neuroblastoma evolution, heterogeneity, and resistance remain inadequately defined, suggesting a role for circulating tumor DNA (ctDNA) sequencing. To define the utility of ctDNA profiling in neuroblastoma, 167 blood samples from 48 high-risk patient
Autor:
Olaf Witt, Stefan Pfister, Andreas von Deimling, Michael D. Taylor, Marco Lodrini, Hedwig E. Deubzer, Paul Northcott, Marc Remke, Annette Kopp-Schneider, Andrey Korshunov, Ina Oehme, Till Milde
Purpose: Medulloblastomas are the most common malignant brain tumors in childhood. Survivors suffer from high morbidity because of therapy-related side effects. Thus, therapies targeting tumors in a specific manner with small molecules such as histon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50cc8c5989b15339505c0b88689e435
https://doi.org/10.1158/1078-0432.c.6519113.v1
https://doi.org/10.1158/1078-0432.c.6519113.v1
Autor:
Hedwig E. Deubzer, Angelika Eggert, Holger Amthauer, Cornelia Eckert, Patrick Hundsdörfer, Johannes H. Schulte, Annabell Szymansky, Jörg Fuchs, Georg Schwabe, Lena Oevermann, Annette Künkele, Erwin Lankes, Jan F. Hollander, Rasmus B. Linke, Constantin Peitz, Maddalena Grimaldi, Annika Sprüssel, Kathy Astrahantseff, Theresa M. Thole-Kliesch, Josefine Graef, Marco Lodrini
Supplementary Figure from Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023bc1f15b2e0ed698b22e7742b1794c
https://doi.org/10.1158/1078-0432.22486932.v1
https://doi.org/10.1158/1078-0432.22486932.v1
Autor:
Hedwig E. Deubzer, Angelika Eggert, Holger Amthauer, Cornelia Eckert, Patrick Hundsdörfer, Johannes H. Schulte, Annabell Szymansky, Jörg Fuchs, Georg Schwabe, Lena Oevermann, Annette Künkele, Erwin Lankes, Jan F. Hollander, Rasmus B. Linke, Constantin Peitz, Maddalena Grimaldi, Annika Sprüssel, Kathy Astrahantseff, Theresa M. Thole-Kliesch, Josefine Graef, Marco Lodrini
Supplementary Data from Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff5da5f034c758093de815f467b900b
https://doi.org/10.1158/1078-0432.22486950.v1
https://doi.org/10.1158/1078-0432.22486950.v1
Autor:
Hedwig E. Deubzer, Angelika Eggert, Holger Amthauer, Cornelia Eckert, Patrick Hundsdörfer, Johannes H. Schulte, Annabell Szymansky, Jörg Fuchs, Georg Schwabe, Lena Oevermann, Annette Künkele, Erwin Lankes, Jan F. Hollander, Rasmus B. Linke, Constantin Peitz, Maddalena Grimaldi, Annika Sprüssel, Kathy Astrahantseff, Theresa M. Thole-Kliesch, Josefine Graef, Marco Lodrini
Purpose:Treating refractory or relapsed neuroblastoma remains challenging. Monitoring body fluids for tumor-derived molecular information indicating minimal residual disease supports more frequent diagnostic surveillance and may have the power to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55434bc554f96e59046df70714a3d7e2
https://doi.org/10.1158/1078-0432.c.6532422
https://doi.org/10.1158/1078-0432.c.6532422
Autor:
Rasmus B. Linke, Karin Schmelz, Joern Toedling, Constantin Peitz, Angelika Eggert, Matthias Fischer, Clemens Messerschmidt, Maddalena Grimaldi, Hedwig E. Deubzer, Dieter Beule, Johannes H. Schulte, Marco Lodrini, Kathy Astrahantseff, Ulrich Keilholz, Annika Sprüssel
Publikováno v:
The Journal of Molecular Diagnostics. 22:1309-1323
The detection and characterization of cell-free DNA (cfDNA) in peripheral blood from neuroblastoma patients may serve as a minimally invasive approach to liquid biopsy. Major challenges in the analysis of cfDNA purified from blood samples are small s
Autor:
Marco Lodrini, Jasmin Wünschel, Theresa M. Thole-Kliesch, Maddalena Grimaldi, Annika Sprüssel, Rasmus B. Linke, Jan F. Hollander, Daniela Tiburtius, Annette Künkele, Johannes H. Schulte, Erwin Lankes, Thomas Elgeti, Patrick Hundsdörfer, Kathy Astrahantseff, Thorsten Simon, Angelika Eggert, Hedwig E. Deubzer
Publikováno v:
Cancers; Volume 14; Issue 9; Pages: 2080
Liquid biopsy strategies in pediatric patients are challenging due to low body weight. This study investigated cfDNA size distribution and concentration in blood, bone marrow, cerebrospinal fluid, and urine from 84 patients with neuroblastoma classif
Autor:
Marco Lodrini, Josefine Graef, Theresa M. Thole-Kliesch, Kathy Astrahantseff, Annika Sprüssel, Maddalena Grimaldi, Constantin Peitz, Rasmus B. Linke, Jan F. Hollander, Erwin Lankes, Annette Künkele, Lena Oevermann, Georg Schwabe, Jörg Fuchs, Annabell Szymansky, Johannes H. Schulte, Patrick Hundsdörfer, Cornelia Eckert, Holger Amthauer, Angelika Eggert, Hedwig E. Deubzer
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(9)
Purpose: Treating refractory or relapsed neuroblastoma remains challenging. Monitoring body fluids for tumor-derived molecular information indicating minimal residual disease supports more frequent diagnostic surveillance and may have the power to de