Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marco Ledri"'
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106234- (2023)
The advent of optogenetic tools has had a profound impact on modern neuroscience research, revolutionizing our understanding of the brain. These tools offer a remarkable ability to precisely manipulate specific groups of neurons with an unprecedented
Externí odkaz:
https://doaj.org/article/c0b1f57aec39486b83e55b6b643c1c54
Autor:
Ana Gonzalez-Ramos, Eliška Waloschková, Apostolos Mikroulis, Zaal Kokaia, Johan Bengzon, Marco Ledri, My Andersson, Merab Kokaia
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Gamma-aminobutyric acid (GABA)-releasing interneurons modulate neuronal network activity in the brain by inhibiting other neurons. The alteration or absence of these cells disrupts the balance between excitatory and inhibitory processes, lea
Externí odkaz:
https://doaj.org/article/a2e6959621cd4950a88ad99f5f68143b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Externí odkaz:
https://doaj.org/article/063ca35b42e842e2afbcca21adaec013
Autor:
Apostolos Mikroulis, Eliška Waloschková, Johan Bengzon, David Woldbye, Lars H. Pinborg, Bo Jespersen, Anna Sanchez Avila, Zsofia I. Laszlo, Christopher Henstridge, Marco Ledri, Merab Kokaia
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13190 (2022)
Glial cell line-derived neurotrophic factor (GDNF) has been shown to counteract seizures when overexpressed or delivered into the brain in various animal models of epileptogenesis or chronic epilepsy. The mechanisms underlying this effect have not be
Externí odkaz:
https://doaj.org/article/e069568f6cbe4a77a0c8534b949954fc
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Gene therapy approaches using viral vectors for the overexpression of target genes have been for several years the focus of gene therapy research against neurological disorders. These approaches deliver robust expression of therapeutic genes, but are
Externí odkaz:
https://doaj.org/article/9fbd913e1ca140628395b010d8625840
Autor:
Eliška Waloschková, Ana Gonzalez-Ramos, Apostolos Mikroulis, Jan Kudláček, My Andersson, Marco Ledri, Merab Kokaia
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13243 (2021)
Epilepsy is a complex disorder affecting the central nervous system and is characterised by spontaneously recurring seizures (SRSs). Epileptic patients undergo symptomatic pharmacological treatments, however, in 30% of cases, they are ineffective, mo
Externí odkaz:
https://doaj.org/article/d8762867ee8643b2bcce4fa6d9e743eb
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2018)
Parvalbumin- (PV-) containing basket cells constitute perisomatic GABAergic inhibitory interneurons innervating principal cells at perisomatic area, a strategic location that allows them to efficiently control the output and synchronize oscillatory a
Externí odkaz:
https://doaj.org/article/50894657d0c14168aba943b9db65e03a
Autor:
Fredrik Berglind, Marco Ledri, Andreas Toft Sørensen, Litsa Nikitidou, Miriam Melis, Pascal Bielefeld, Deniz Kirik, Karl Deisseroth, My Andersson, Merab Kokaia
Publikováno v:
Neurobiology of Disease, Vol 65, Iss , Pp 133-141 (2014)
Synchronized activity is common during various physiological operations but can culminate in seizures and consequently in epilepsy in pathological hyperexcitable conditions in the brain. Many types of seizures are not possible to control and impose s
Externí odkaz:
https://doaj.org/article/3e8d81b144a640f789dab9c832dde6d7
Autor:
Ana, Gonzalez-Ramos, Kerstin, Laurin, Fredrik, Berglind, Marco, Ledri, Merab, Kokaia, My, Andersson
Publikováno v:
Journal of Visualized Experiments.
A reduced number or dysfunction of inhibitory interneurons is a common contributor to neurodevelopmental disorders. Therefore, cell therapy using interneurons to replace or mitigate the effects of altered neuronal circuits is an attractive therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49233ee5e05739101899924dc93ce3f
https://doi.org/10.3791/64272-v
https://doi.org/10.3791/64272-v
Autor:
Kokaia, Apostolos Mikroulis, Eliška Waloschková, Johan Bengzon, David Woldbye, Lars H. Pinborg, Bo Jespersen, Anna Sanchez Avila, Zsofia I. Laszlo, Christopher Henstridge, Marco Ledri, Merab
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13190
Glial cell line-derived neurotrophic factor (GDNF) has been shown to counteract seizures when overexpressed or delivered into the brain in various animal models of epileptogenesis or chronic epilepsy. The mechanisms underlying this effect have not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::ac7c348d0ddb37196c9de1dfe72a2c8d