Výsledky vyhledávání - "Marco Kessler"

Differential Bile Acid Detection in Refractory GERD Patient Saliva Using a Simple and Sensitive Liquid Chromatography Tandem Mass Spectrometry Approach

Autor: Kimberly Chambert, Marco Kessler, Yan Chen, Nisha Perez, Mark G. Currie, Maria D. Ribadeneira

Publikováno v: Journal of Clinical Gastroenterology. 56:218-223

Goals The aim was to measure bile acids in human saliva using a sensitive ultraperformance liquid chromatography tandem mass spectrometry analysis method to distinguish quantitative differences in refractory gastroesophageal reflux disease (GERD) pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0786f4a56b721438d5549dd283e92889
https://doi.org/10.1097/mcg.0000000000001525

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The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes

Autor: Marco Kessler, Jaime L. Masferrer, Nicholas Robert Perl, Sylvie G. Bernier, Iris Navarro, Gerhard Hannig, W. Daniel Stamer, Renee Sarno, Pei Ge

Publikováno v: Investigative Ophthalmology & Visual Science

Purpose The nitric oxide (NO)-cyclic guanosine-3',5'-monophosphate (cGMP) pathway regulates aqueous humor outflow and therefore, intraocular pressure. We investigated the pharmacologic effects of the soluble guanylate cyclase (sGC) stimulator IWP-953

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488adaa99ff605431e85671702d259de
http://europepmc.org/articles/PMC4811179

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Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine

Autor: Marco Kessler, Robert Solinga, Boris Tchernychev, Inmaculada Silos-Santiago, Nadia A. Ameen, David Arthur, Md. Kaimul Ahsan, Gerhard Hannig, Cristina I. Linde

Publikováno v: Physiological Reports

The transmembrane receptor guanylyl cyclase‐C (GC‐C), expressed on enterocytes along the intestine, is the molecular target of the GC‐C agonist peptide linaclotide, an FDA‐approved drug for treatment of adult patients with Irritable Bowel Syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33660aac1a5e50be1c19e49cfedb2c27
https://pubmed.ncbi.nlm.nih.gov/28592587

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Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation

Autor: Robert Solinga, Jenny Tobin, Alexander P. Bryant, Marco Kessler, Mark G. Currie, Gerhard Hannig, James Wakefield, Caroline B. Kurtz, Wilmin Bartolini, Robert W. Busby, Carolyn S. Higgins

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 344:196-206

Linaclotide, a potent guanylate cyclase C agonist, is a therapeutic peptide approved in the United States for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. We present for the first time the metabolis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a955acace8f1769f4e3f6b26ffb3eb3
https://doi.org/10.1124/jpet.112.199430

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Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

Autor: Marco Kessler, Etchell A. Cordero, Robert W. Busby, Wilmin Bartolini, Gerhard Hannig, Mark G. Currie, Caroline B. Kurtz, Jenny Tobin, Alexander P. Bryant, Shalina Mahajan-Miklos, Robert Solinga, Christine M. Pierce, Mitchell B. Cohen

Publikováno v: Life Sciences. 86:760-765

Aims Linaclotide is an orally administered 14-amino acid peptide being developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. We determined the stability of linaclotide in the intestine, mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d74fdae2ce259baa4e2118fc30a5d99
https://doi.org/10.1016/j.lfs.2010.03.015

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Control and Characteristic Map Generation of Permanent Magnet Synchronous Machines and Induction Machines with Squirrel Cage

Autor: Thomas Lienhard Schmitt, Marco Keßler, Markus Andres

Publikováno v: Linköping Electronic Conference Proceedings.

Due to different requirements for simulation during the design process of an electric drive system, investigations were carried out to supply models of different stages with consistent sets of parameters. Therefore physical models of the Modelica Sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da11d8a591e5650cf99abbdd0d733523
https://doi.org/10.3384/ecp140961151

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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Autor: Etchell A. Cordero, Robert Solinga, Mark G. Currie, Robert W. Busby, Caroline B. Kurtz, Marco Kessler, Li Jing Sun, Shalina Mahajan-Miklos, Wilmin Bartolini, Alexander P. Bryant, Gerhard Hannig, Christine M. Pierce, Jenny Tobin

Publikováno v: European journal of pharmacology. 649(1-3)

Linaclotide is a first-in-class, orally administered 14-amino acid peptide that is in development for the treatment of irritable bowel syndrome with constipation and chronic constipation. We have characterized the solution structure of linaclotide, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4926aec843727e758afb1ae8d2e73c4
https://pubmed.ncbi.nlm.nih.gov/20863829

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