Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marco Gymnopoulos"'
Autor:
Marco Gymnopoulos, Oscar Betancourt, Vincent Blot, Ryo Fujita, Diana Galvan, Vincent Lieuw, Sophie Nguyen, Jeanette Snedden, Christine Stewart, Jose Villicana, Jon Wojciak, Eley Wong, Raul Pardo, Neki Patel, Francois D’Hooge, Balakumar Vijayakrishnan, Conor Barry, John A. Hartley, Philip W. Howard, Roland Newman, Julia Coronella
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 54-68 (2020)
cMet is a well‐characterized oncogene that is the target of many drugs including small molecule and biologic pathway inhibitors, and, more recently, antibody–drug conjugates (ADCs). However, the clinical benefit from cMet‐targeted therapy has b
Externí odkaz:
https://doaj.org/article/deb621ff4dba44b3a242c7c4570c902e
Supplementary Data from Requirement of Phosphatidylinositol(3,4,5)Trisphosphate in Phosphatidylinositol 3-Kinase-Induced Oncogenic Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f1c5bec188fd923df4d8702e974dc9
https://doi.org/10.1158/1541-7786.22519357
https://doi.org/10.1158/1541-7786.22519357
Autor:
Andrew M. Lowy, Marco Gymnopoulos, Hervé Tiriac, Alexis A. Wascher, Eric Wong, Dawn Jaquish, Evangeline S. Mose, Edgar Esparza, Oscar Betancourt, Alex Cazes
Purpose:Pancreatic cancer is an aggressive disease associated with a poor 5-year overall survival. Most patients are ineligible for surgery due to late diagnosis and are treated primarily with chemotherapy with very limited success. Pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556bc0a604563eb965278ad8ebc346b1
https://doi.org/10.1158/1078-0432.c.6530867
https://doi.org/10.1158/1078-0432.c.6530867
Autor:
Andrew M. Lowy, Marco Gymnopoulos, Hervé Tiriac, Alexis A. Wascher, Eric Wong, Dawn Jaquish, Evangeline S. Mose, Edgar Esparza, Oscar Betancourt, Alex Cazes
MET expression in pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d2163ee84448114b8db94c4cb12811
https://doi.org/10.1158/1078-0432.22482251.v1
https://doi.org/10.1158/1078-0432.22482251.v1
Autor:
Marco Gymnopoulos, Tima Thomas, Diana Gasper, Judith Anderton, Ravinder Tammali, Ed Rosfjord, Nick Durham, Chris Ward, Claire Myers, Jixin Wang, Wenyan Zhong, Simon Christ, Lina Meinecke, Katharina Nekolla, Laura Sebastian Monasor, Roger Dodd, Neki Patel, Mark Albertella, Jorge Zeron-Medina, Paula Fraenkel, Puja Sapra
Publikováno v:
Cancer Research. 83:LB025-LB025
Folate receptor alpha (FRα) is a cell surface GPI-anchored protein overexpressed in several solid tumors with highest prevalence in ovarian cancer and lung adenocarcinoma but restricted expression in normal tissues. An antibody drug conjugate (ADC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c657dc620f6c5ef3de670bb26a735c37
https://doi.org/10.1158/1538-7445.am2023-lb025
https://doi.org/10.1158/1538-7445.am2023-lb025
Autor:
Alex Cazes, Krista Kinneer, Bilal Omar, Jon Chesebrough, Judith Anderton, Jixin Wang, Anna D. Staniszewska, Steven Arbitman, Kalyani Daita, Himanshi Desai, Yoshimi Johnson, Raymond Rothstein, Marco Gymnopoulos, Giulia Fabbri, Zachary A. Cooper, Mark Albertella, Scott A. Hammond, Sabina Cosulich, Nadia Luheshi, Puja Sapra
Publikováno v:
Cancer Research. 83:2947-2947
B7-H4 is a cell-surface protein overexpressed in several tumor types and is most prevalent in triple-negative breast (TNBC) cancer (74%), ovarian carcinoma (77%), endometrial carcinoma (94%), and cholangiocarcinoma (89%). In contrast, it has a limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7606466bf8f80b20b945b18e935f465b
https://doi.org/10.1158/1538-7445.am2023-2947
https://doi.org/10.1158/1538-7445.am2023-2947
Autor:
Vaughn V. Smider, Tsotne Javahishvili, Jinming Xia, Jun Y. Axup, Nick Knudsen, Prof.Dr. Peter G. Schultz, Sandra Biroc, Ning Zou, V. Deshmukh, Mark Shimazu, Sumith A. Kularatne, Ying Sun, Jason Pinkstaff, Anthony Manibusan, Chan Hyuk Kim, Shailaja Srinagesh, Semsi Ensari, Marco Gymnopoulos
Publikováno v:
Angewandte Chemie. 125:12323-12326
Herein, we describe the synthesis of a chemically defined anti-CD3 Fab-folate conjugate that targets cytotoxic T cells to folate receptor positive (FR+) tumors. The unnatural amino acid pacetylphenylalanine (pAcPhe) was site-specifically incorporated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ea54bd1f079e16a7657b690f76f3c0
https://doi.org/10.1002/ange.201306866
https://doi.org/10.1002/ange.201306866
Publikováno v:
Molecular Cancer Research. 7:1132-1138
Phosphatidylinositol 3-kinases (PI3K) are divided into three classes, which differ in their substrates and products. Class I generates the inositol phospholipids PI(3)P, PI(3,4)P2, and PI(3,4,5)P3 referred as PIP, PIP2, and PIP3, respectively. Class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3afe77dcce0dd10c0c727d87fadb21
https://doi.org/10.1158/1541-7786.mcr-09-0068
https://doi.org/10.1158/1541-7786.mcr-09-0068
Publikováno v:
Current Opinion in Genetics & Development. 19:12-17
Research on PI 3-kinase (PI3K) is undergoing significant shifts in emphasis. Questions that have been dormant for some time are coming to the forefront, such as the relationship of PTEN to PI3K and the role of AKT in PI3K-driven oncogenesis. Two non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3453c8f9c2484b6707374cbab4feb549
https://doi.org/10.1016/j.gde.2008.11.011
https://doi.org/10.1016/j.gde.2008.11.011
Publikováno v:
Trends in Biochemical Sciences. 32:342-349
Cancer-specific mutations in the catalytic subunit of phosphatidylinositol 3-kinase (PI3K) p110 alpha occur in diverse tumors in frequencies that can exceed 30%. The majority of these mutations map to one of three hot spots in the gene, and the rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbae255ef6632a4bdcb76cf9fa8c814
https://doi.org/10.1016/j.tibs.2007.05.005
https://doi.org/10.1016/j.tibs.2007.05.005