Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marco Gusciglio"'
Autor:
Marco Gusciglio, Luciana Giardino, Laura Calzà, Sandra Sivilia, Michele Sannia, Vito Antonio Baldassarro, Luca Lorenzini, Alessandro Giuliani
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 78:101-112
We describe age-related histological structure and molecular changes of the neurovascular unit (NVU) in the cerebral cortex of Tg2576 and age-matched wild-type (WT) mice. Major results can be summarized as follows: (i) β-amyloid (6E10)-immunoreactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a89214a4c94913702562ad530e095b6
https://doi.org/10.1093/jnen/nly125
https://doi.org/10.1093/jnen/nly125
Autor:
Luca Lorenzini, Marco Gusciglio, Laura Calzà, Michele Sannia, Luciana Giardino, Marco Sanna, Vito Antonio Baldassarro, Andrea Bighinati
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8606, p 8606 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences
Volume 22
Issue 16
“Neuroplasticity” is often evoked to explain adaptation and compensation after acute lesions of the Central Nervous System (CNS). In this study, we investigated the modification of 80 genes involved in synaptic plasticity at different times (24 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa954f21a2b0cb4d3cef36cf7da3093
http://hdl.handle.net/11585/862102
http://hdl.handle.net/11585/862102
Autor:
Marco Gusciglio, Marco Alessandri, Alessandro Giuliani, Chiara Mangano, Mercedes Fernandez, Vito Antonio Baldassarro, Laura Calzà, Luciana Giardino, Roberta Torricella, Sandra Sivilia, Luca Lorenzini
Publikováno v:
Current Topics in Medicinal Chemistry. 13:1843-1852
The drug discovery for disease-modifying agents in Alzheimer disease (AD) is facing a failure of clinical trials with drugs based on two driving hypotheses, i.e. the cholinergic and amyloidogenic hypotheses. In this article we recapitulate the main a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::624336ea730287b489d13a681f632959
https://doi.org/10.2174/15680266113139990140
https://doi.org/10.2174/15680266113139990140
Autor:
Maria Francesca Baroc, Marco Gusciglio, Alessandro Giuliani, Simone Ottonello, Sandra Sivilia, Laura Calzà, Mercedes Fernandez, Luca Ferraro, Luciana Giardino, Vito Antonio Baldassarro, Arturo Roberto Viscomi, Vladimiro Pietrini, Gino Villetti, Chiara Mangano, Bruno P. Imbimbo, Luca Lorenzini
Publikováno v:
BMC Neuroscience
Background Alzheimer disease is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The pathological hallmarks includes extracellular amyloid plaques and intraneuronal neurofibrillary tangles, but the primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850e61a5cb79bf5dfb41d65a35f31e32
http://hdl.handle.net/11392/1804300
http://hdl.handle.net/11392/1804300
Autor:
Luciana Giardino, Luca Lorenzini, Gino Villetti, Mercedes Fernandez, Bruno P. Imbimbo, Maria Francesca Baroc, Sandra Sivilia, Alessandro Giuliani, Marco Gusciglio, Vladimiro Pietrini, Laura Calzà
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44bb4a60073320247e9223015db0d856
https://doi.org/10.1016/j.jalz.2011.05.1455
https://doi.org/10.1016/j.jalz.2011.05.1455
Autor:
Marco Gusciglio, V. Pietrini, Alessandro Giuliani, Bruno P. Imbimbo, Laura Calzà, Luca Lorenzini, Gino Villetti, Luciana Giardino, Maria Francesca Baroc
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9613e7f78eba34bddaa7ea5eb2b2e735
https://doi.org/10.1016/j.jalz.2010.05.2014
https://doi.org/10.1016/j.jalz.2010.05.2014
Autor:
Vladimiro Pietrini, Elda Del Giudice, Bruno P. Imbimbo, Marco Gusciglio, Antonello D'Arrigo, G Villetti, Alberta Leon, Luciana Giardino, Alessandro Giuliani, Sandra Sivilia, Laura Calzà
The effects of compounds interfering with gamma-secretase, the enzymatic complex responsible of the formation of the amyloid-beta (Abeta) peptide from amyloid-beta protein precursor (AbetaPP), on plaque deposition in transgenic mouse models of Alzhei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a42ba8269b25181e19723294a3b612
http://hdl.handle.net/11585/85752
http://hdl.handle.net/11585/85752
Autor:
G. D’Intino, Marco Gusciglio, Alessandro Massella, Luca Ferraro, Sandra Sivilia, Luciana Giardino, Laura Calzà
Publikováno v:
Brain research. 1301
No causal treatment of ataxias is available at the moment, and so symptomatic and disease-modifying therapies are regarded as a reliable possibility for this complex group of movement disorders. In order to explore possible pharmacological strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fa46d57dc464ead79647e4e58c04dc
https://pubmed.ncbi.nlm.nih.gov/19747469
https://pubmed.ncbi.nlm.nih.gov/19747469
Autor:
Alessandro Giuliani, Bruno P. Imbimbo, Luca Lorenzini, Marco Gusciglio, Gino Villetti, Luciana Giardino, Laura Calzà
Publikováno v:
Alzheimer's & Dementia. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb55d8ef3ca3ae6da1cf3789452d27a7
https://doi.org/10.1016/j.jalz.2009.04.924
https://doi.org/10.1016/j.jalz.2009.04.924
Autor:
Alessandro Massella, Luciana Giardino, G. D’Intino, Marco Gusciglio, Sven-Ove Ögren, Tomas Hökfelt, Laura Calzà, Stefania Pirondi, Eugenia Kuteeva
Publikováno v:
Brain research. 1138
The cholinergic forebrain system is involved in learning and memory, and its age-dependent decline correlates with a decrease in cognitive performance. Since the neuropeptide galanin participates in cholinergic neuron regulation, we have studied 19-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13f42cfaccb6b5881150304c5fe3891
https://pubmed.ncbi.nlm.nih.gov/17266943
https://pubmed.ncbi.nlm.nih.gov/17266943