Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Marco Foiani"'
Autor:
Chiara Lucca, Elisa Ferrari, Ghadeer Shubassi, Arta Ajazi, Ramveer Choudhary, Christopher Bruhn, Vittoria Matafora, Angela Bachi, Marco Foiani
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114281- (2024)
Summary: Survival from UV-induced DNA lesions relies on nucleotide excision repair (NER) and the Mec1ATR DNA damage response (DDR). We study DDR and NER in aging cells and find that old cells struggle to repair DNA and activate Mec1ATR. We employ pha
Externí odkaz:
https://doaj.org/article/4d97bca2f57542f98f465facc5dc6eda
Autor:
Ramveer Choudhary, Joanna Niska-Blakie, Mohamood Adhil, Giordano Liberi, Yathish Jagadheesh Achar, Michele Giannattasio, Marco Foiani
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112747- (2023)
Summary: Replication forks terminate at TERs and telomeres. Forks that converge or encounter transcription generate topological stress. Combining genetics, genomics, and transmission electron microscopy, we find that Rrm3hPif1 and Sen1hSenataxin heli
Externí odkaz:
https://doaj.org/article/2dcf6ec0f4454e4289a45fb4b96277f1
Autor:
Riccardo Cazzoli, Francesco Romeo, Isabella Pallavicini, Sebastiano Peri, Mauro Romanenghi, Juan Alberto Pérez-Valencia, Eman Hagag, Filippo Ferrucci, Mohamed Elgendy, Orazio Vittorio, Salvatore Pece, Marco Foiani, Jukka Westermarck, Saverio Minucci
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112616- (2023)
Summary: Combined inhibition of oxidative phosphorylation (OXPHOS) and glycolysis has been shown to activate a PP2A-dependent signaling pathway, leading to tumor cell death. Here, we analyze highly selective mitochondrial complex I or III inhibitors
Externí odkaz:
https://doaj.org/article/2e89761a53e748da9ba4ce42a1fbb8c9
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Elevated histone density is associated with global histone acetylation, histone deacetylase inhibitor sensitivity and altered mitochondrial proteome composition, with histone regulator HMGB1 linked to histone density aberrations in many cancer cell l
Externí odkaz:
https://doaj.org/article/8d7381abed8640338b03675c8766716c
Autor:
Divya Purushothaman, Laura F. Bianchi, Dmitry Penkov, Alessandro Poli, Qingsen Li, Jelena Vermezovic, Francesca M. Pramotton, Ramveer Choudhary, Fabrizio A. Pennacchio, Elena Sommariva, Marco Foiani, Nils Gauthier, Paolo Maiuri, Francesco Blasi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The transcription factor PREP1 binds to promoter regions of SUN1, SUN2 and LAP2 genes and promotes nuclear stiffness, and its depletion results in impaired mechanotransduction.
Externí odkaz:
https://doaj.org/article/efb52baa31d14c348620b90920ea3ae6
Autor:
Martin Kosar, Michele Giannattasio, Daniele Piccini, Apolinar Maya-Mendoza, Francisco García-Benítez, Jirina Bartkova, Sonia I. Barroso, Hélène Gaillard, Emanuele Martini, Umberto Restuccia, Miguel Angel Ramirez-Otero, Massimiliano Garre, Eleonora Verga, Miguel Andújar-Sánchez, Scott Maynard, Zdenek Hodny, Vincenzo Costanzo, Amit Kumar, Angela Bachi, Andrés Aguilera, Jiri Bartek, Marco Foiani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication str
Externí odkaz:
https://doaj.org/article/18fbf66c3f8442a6835b1d14c7f9ffa2
Autor:
Ilaria Stadiotti, Rosaria Santoro, Alessandro Scopece, Sergio Pirola, Anna Guarino, Gianluca Polvani, Angela Serena Maione, Flora Ascione, Qingsen Li, Domenico Delia, Marco Foiani, Giulio Pompilio, Elena Sommariva
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome characterized by impaired left ventricular (LV) diastolic function, with normal LV ejection fraction. Aortic valve stenosis can cause an HFpEF-like syndrome by inducin
Externí odkaz:
https://doaj.org/article/1e3d73f6c19b42059e44ad4cc10cb214
Autor:
Gururaj Rao Kidiyoor, Qingsen Li, Giulia Bastianello, Christopher Bruhn, Irene Giovannetti, Adhil Mohamood, Galina V. Beznoussenko, Alexandre Mironov, Matthew Raab, Matthieu Piel, Umberto Restuccia, Vittoria Matafora, Angela Bachi, Sara Barozzi, Dario Parazzoli, Emanuela Frittoli, Andrea Palamidessi, Tito Panciera, Stefano Piccolo, Giorgio Scita, Paolo Maiuri, Kristina M. Havas, Zhong-Wei Zhou, Amit Kumar, Jiri Bartek, Zhao-Qi Wang, Marco Foiani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and
Externí odkaz:
https://doaj.org/article/ef3b7523ea5c4ef99f9147b73d2702d2
Autor:
Christopher Bruhn, Arta Ajazi, Elisa Ferrari, Michael Charles Lanz, Renaud Batrin, Ramveer Choudhary, Adhish Walvekar, Sunil Laxman, Maria Pia Longhese, Emmanuelle Fabre, Marcus Bustamente Smolka, Marco Foiani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The relationship between DNA damage response (DDR) and regulation of the tolerance to glucose restriction is currently unclear. Here the authors reveal that maintaining a physiological level of histones by Rad53-Spt21 is necessary for glucose toleran
Externí odkaz:
https://doaj.org/article/c1334c64c88341dd9b8f7f4e9f177694
Autor:
Christopher Bruhn, Marco Foiani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-3 (2019)
The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that cha
Externí odkaz:
https://doaj.org/article/f367c6151ba84697a0a594a8dd42fb3f