Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marco Egle"'
Autor:
Marco Egle, Jennifer A. Deal, Keenan A. Walker, Dean F. Wong, A. Richey Sharrett, Rebecca F. Gottesman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Retinal microvascular signs are accessible measures of early alterations in microvascular dysregulation and have been associated with dementia; it is unclear if they are associated with AD (Alzheimer’s disease) pathogenesis as a
Externí odkaz:
https://doaj.org/article/919fd71fdf8a4a90864f4457f71616b9
Autor:
Christopher N. Osuafor, Catarina Rua, Andrew D. Mackinnon, Marco Egle, Philip Benjamin, Daniel J. Tozer, Christopher T. Rodgers, Hugh S. Markus
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract 7 Tesla-field-strength (7 T) Magnetic Resonance Imaging allows the small perforating arteries in the brain to be visualised, and this modality may allow visualisation of the arterial pathology in cerebral small vessel disease. Most studies h
Externí odkaz:
https://doaj.org/article/edec8c3a7f954c6e8ed75f0e4f82e61a
Autor:
Yi Lin Ng, Chuen Seng Tan, Marco Egle, Bibek Gyanwali, Daniel J. Tozer, Hugh S. Markus, Christopher Chen, Saima Hilal
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 5, Iss , Pp 100174- (2023)
Objective: Median and peak height of fractional anisotropy (FA) and mean diffusivity (MD) are diffusion tensor imaging (DTI) markers used to quantify white matter microstructure changes. We examine the association of DTI histogram-derived measures in
Externí odkaz:
https://doaj.org/article/af89a68d17194026892a7600caec7122
Autor:
Marco Egle, Saima Hilal, Anil M Tuladhar, Lukas Pirpamer, Steven Bell, Edith Hofer, Marco Duering, James Wason, Robin G Morris, Martin Dichgans, Reinhold Schmidt, Daniel J Tozer, Thomas R. Barrick, Christopher Chen, Frank-Erik de Leeuw, Hugh S Markus
Publikováno v:
NeuroImage: Clinical, Vol 35, Iss , Pp 103114- (2022)
Background: DTI is sensitive to white matter (WM) microstructural damage and has been suggested as a surrogate marker for phase 2 clinical trials in cerebral small vessel disease (SVD). The study’s objective is to establish the best way to analyse
Externí odkaz:
https://doaj.org/article/27c0f610501c49f9b5fcc3908b20665b
Publikováno v:
Brain and Behavior, Vol 11, Iss 5, Pp n/a-n/a (2021)
Abstract Background Cerebral small vessel disease (SVD) leads to reduced quality of life (QOL), but the mechanisms underlying this relationship remain unknown. This study investigated multivariate relationships between radiological markers of SVD and
Externí odkaz:
https://doaj.org/article/e23159742c4542b38a6da87c82cb8911
Autor:
D Tozer, Lukas Pirpamer, Edith Hofer, Saima Hilal, Marco Duering, Robin G. Morris, Reinhold Schmidt, Hugh S. Markus, Anil M. Tuladhar, Christopher Chen, Marco Egle, Frank-Erik de Leeuw, James Wason, Martin Dichgans
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry 93(1), 14-23 (2022). doi:10.1136/jnnp-2021-326571
Journal of Neurology, Neurosurgery, and Psychiatry, 93, 1, pp. 14-23
Journal of Neurology, Neurosurgery, and Psychiatry, 93, 14-23
Journal of Neurology, Neurosurgery, and Psychiatry, 93, 1, pp. 14-23
Journal of Neurology, Neurosurgery, and Psychiatry, 93, 14-23
ObjectivesIt has been suggested that diffusion tensor imaging (DTI) measures sensitive to white matter (WM) damage may predict future dementia risk not only in cerebral small vessel disease (SVD), but also in mild cognitive impairment. To determine w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cee073bd244635732a03e337dcf23f
Autor:
Hugh S. Markus, Wiesje M. van Der Flier, Eric E. Smith, Philip Bath, Geert Jan Biessels, Emily Briceno, Amy Brodtman, Hugues Chabriat, Christopher Chen, Frank-Erik de Leeuw, Marco Egle, Aravind Ganesh, Marios K. Georgakis, Rebecca F. Gottesman, Sun Kwon, Lenore Launer, Vincent Mok, John O’Brien, Lois Ottenhoff, Sarah Pendlebury, Edo Richard, Perminder Sachdev, Reinhold Schmidt, Melanie Springer, Stefan Tiedt, Joanna M. Wardlaw, Ana Verdelho, Alastair Webb, David Werring, Marco Duering, Deborah Levine, Martin Dichgans
Publikováno v:
Markus, H S, van der Flier, W M, Smith, E E, Bath, P, Biessels, G J, Briceno, E, Brodtman, A, Chabriat, H, Chen, C, de Leeuw, F-E, Egle, M, Ganesh, A, Georgakis, M K, Gottesman, R F, Kwon, S, Launer, L, Mok, V, O'Brien, J, Ottenhoff, L, Pendlebury, S, Richard, E, Sachdev, P, Schmidt, R, Springer, M, Tiedt, S, Wardlaw, J M, Verdelho, A, Webb, A, Werring, D, Duering, M, Levine, D & Dichgans, M 2022, ' Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE) : A Review ', JAMA Neurology, vol. 79, no. 11, pp. 1187-1198 . https://doi.org/10.1001/jamaneurol.2022.2262
Jama Neurology, 79, 1187-1198
Jama Neurology, 79, 11, pp. 1187-1198
Jama Neurology, 79, 1187-1198
Jama Neurology, 79, 11, pp. 1187-1198
ImportanceCerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology. Disease mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd7f9019360c167348cdb2cbf5bc722
Autor:
Robin B Brown, Daniel J Tozer, Marco Egle, Anil M Tuladhar, Frank-Erik de Leeuw, Hugh S Markus
Publikováno v:
International Journal of Stroke. :174749302311691
Background and objectives: It has been suggested that white matter hyperintensity lesions (WMHs), which typically progress over time, can also regress, and that this might be associated with favorable cognitive performance. We determined the prevalen
Autor:
Christopher N. Osuafor, Catarina Rua, Andrew D. Mackinnon, Marco Egle, Philip Benjamin, Daniel J. Tozer, Christopher T. Rodgers, Hugh S. Markus
Background And Purpose7 Tesla-field-strength (7T) Magnetic Resonance Imaging (MRI) allows the small perforating arteries in the brain to be visualised, and this modality may allow visualisation of the arterial pathology in cerebral small vessel disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1130ab086c0581f2458af94d9bc53970
https://doi.org/10.1101/2022.03.23.22272852
https://doi.org/10.1101/2022.03.23.22272852
Publikováno v:
Brain and Behavior
Brain and Behavior, Vol 11, Iss 5, Pp n/a-n/a (2021)
Brain and Behavior, Vol 11, Iss 5, Pp n/a-n/a (2021)
Background Cerebral small vessel disease (SVD) leads to reduced quality of life (QOL), but the mechanisms underlying this relationship remain unknown. This study investigated multivariate relationships between radiological markers of SVD and domain