Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Marco De Giorgi"'
Autor:
Teresa Perillo, Marco de Giorgi, Umberto Maria Papace, Antonietta Serino, Renato Cuocolo, Andrea Manto
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 4, Pp 545-555 (2023)
In the past few years, artificial intelligence (AI) has been increasingly used to create tools that can enhance workflow in medicine. In particular, neuro-oncology has benefited from the use of AI and especially machine learning (ML) and radiogenomic
Externí odkaz:
https://doaj.org/article/247c0bf3f331495bbed8869272a02a94
Autor:
Alexandria M. Doerfler, So Hyun Park, Julia M. Assini, Amer Youssef, Lavanya Saxena, Adam B. Yaseen, Marco De Giorgi, Marcel Chuecos, Ayrea E. Hurley, Ang Li, Santica M. Marcovina, Gang Bao, Michael B. Boffa, Marlys L. Koschinsky, William R. Lagor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 337-351 (2022)
Lipoprotein(a) (Lp(a)) represents a unique subclass of circulating lipoprotein particles and consists of an apolipoprotein(a) (apo(a)) molecule covalently bound to apolipoprotein B-100. The metabolism of Lp(a) particles is distinct from that of low-d
Externí odkaz:
https://doaj.org/article/e69bb16736e64616a0e3d81f0b495788
Autor:
Andrea Ponsiglione, Michele Gambardella, Roberta Green, Valeria Cantoni, Carmela Nappi, Raffaele Ascione, Marco De Giorgi, Renato Cuocolo, Antonio Pisani, Mario Petretta, Alberto Cuocolo, Massimo Imbriaco
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 24, Iss 1, Pp 1-14 (2022)
Abstract Background T1 mapping is an established cardiovascular magnetic resonance (CMR) technique that can characterize myocardial tissue. We aimed to determine the weighted mean native T1 values of Anderson-Fabry disease (AFD) patients and the stan
Externí odkaz:
https://doaj.org/article/3fb72dd35d324d749eeffbcdbe366412
Autor:
Andrea Ponsiglione, Marco De Giorgi, Raffaele Ascione, Carmela Nappi, Luca Sanduzzi, Antonio Pisani, Serena Dell’Aversana, Alberto Cuocolo, Massimo Imbriaco
Publikováno v:
Diagnostics, Vol 13, Iss 15, p 2598 (2023)
Anderson-Fabry disease (AFD) is a rare multisystem X-linked lysosomal storage disorder caused by α-galactosidase A enzyme deficiency. Long-term cardiac involvement in AFD results in left ventricular hypertrophy and myocardial fibrosis, inducing seve
Externí odkaz:
https://doaj.org/article/bc37bcaa696845dba9d814c4f6882846
Autor:
Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R. Tanner, Rong-Chi Hu, Michael W. Pennington, William R. Lagor, Christine Beeton
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. S
Externí odkaz:
https://doaj.org/article/ca2fd58e706445a2b6b685c437aebfe2
Autor:
Arianna Scagliotti, Laura Capizzi, Marina Elena Cazzaniga, Alice Ilari, Marco De Giorgi, Nicoletta Cordani, Matteo Gallazzi, Antonino Bruno, Giuseppe Pelosi, Adriana Albini, Marialuisa Lavitrano, Emanuela Grassilli, Maria Grazia Cerrito
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
High-dose standard-of-care chemotherapy is the only option for triple-negative breast cancer (TNBC) patients, which eventually die due to metastatic tumors. Recently, metronomic chemotherapy (mCHT) showed advantages in treating TNBCs leading us to in
Externí odkaz:
https://doaj.org/article/5f272eaaf6e9491ca96069aa45a0c264
Autor:
Marco De Giorgi, Ang Li, Ayrea Hurley, Mercedes Barzi, Alexandria M. Doerfler, Nikitha A. Cherayil, Harrison E. Smith, Jonathan D. Brown, Charles Y. Lin, Karl-Dimiter Bissig, Gang Bao, William R. Lagor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 656-669 (2021)
Clinical application of somatic genome editing requires therapeutics that are generalizable to a broad range of patients. Targeted insertion of promoterless transgenes can ensure that edits are permanent and broadly applicable while minimizing risks
Externí odkaz:
https://doaj.org/article/40cb0ffc6dfe4a53a49a6c7a56786698
Autor:
Martina Caruso, Arnaldo Stanzione, Carlo Ricciardi, Fabiola Di Dato, Noemi Pisani, Gregorio Delli Paoli, Marco De Giorgi, Raffaele Liuzzi, Carmine Mollica, Valeria Romeo, Raffaele Iorio, Mario Cesarelli, Arturo Brunetti, Simone Maurea
Publikováno v:
Bioengineering, Vol 10, Iss 3, p 306 (2023)
Kasai portoenterostomy (KP) plays a crucial role in the treatment of biliary atresia (BA). The aim is to correlate MRI quantitative findings of native liver survivor BA patients after KP with a medical outcome. Thirty patients were classified as havi
Externí odkaz:
https://doaj.org/article/7875379c28d94e9ca8f3c970de1e9c6d
Autor:
Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton, Alexandria M. Doerfler, Ayrea Hurley, Ang Li, Rachel H. Hsu, Mia Furgurson, Kalyani R. Patel, Jun Han, Christoph H. Borchers, William R. Lagor
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesy
Externí odkaz:
https://doaj.org/article/ed795593e77944b1aba45644fccaf0d5
Autor:
Nunzia Pastore, Tuong Huynh, Niculin J. Herz, Alessia Calcagni’, Tiemo J. Klisch, Lorenzo Brunetti, Kangho Ho Kim, Marco De Giorgi, Ayrea Hurley, Annamaria Carissimo, Margherita Mutarelli, Niya Aleksieva, Luca D’Orsi, William R. Lagor, David D. Moore, Carmine Settembre, Milton J. Finegold, Stuart J. Forbes, Andrea Ballabio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and t
Externí odkaz:
https://doaj.org/article/dac8c6aa736f4598a4966ab084bf32fc