Výsledky vyhledávání - "Marco Ceruso"

The Promise of Artificial Intelligence in Supporting an Aging Population

Autor: Sara J. Czaja, Marco Ceruso

Publikováno v: Journal of Cognitive Engineering and Decision Making. 16:182-193

The aging of the population is a great achievement but also poses challenges for society, families, and older adults. Because of age-related changes in abilities, many older adults encounter difficulties that threaten independence and well-being. Fur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9adb9761e9eb641ae05fa72575a8bb39
https://doi.org/10.1177/15553434221129914

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A PILOT ASSESSMENT OF A TABLET-BASED INTERVENTION FOR HOMEBOUND OR SOCIALLY ISOLATED OLDER ADULTS WITH DEPRESSION

Autor: Caroline Galo, Natalie Benda, Isabel Olivia Rollandi, Sara Czaja, Marco Ceruso, Jo Anne Sirey

Publikováno v: Innovation in Aging. 6:878-878

Older adults who are homebound or socially isolated have high rates of loneliness and depression with fewer opportunities for treatment. Our team extended an existing psychotherapy intervention (Engage & Connect) to improve access to mental health ca

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https://doi.org/10.1093/geroni/igac059.3135

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Novel non-squalenoid photoaffinity labels for mammalian squalene epoxidase

Autor: Marco Ceruso, Glenn D. Prestwich

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:2179-2184

Specific affinity labeling of the squalene binding site of squalene epoxidase remains an elusive goal. We wish to report here the design and synthesis of six novel, non-squalenoid, photoaffinity labels for squalene epoxidase, based on the potent inhi

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https://doi.org/10.1016/s0960-894x(00)80067-0

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Hinge and Twist Rigid Body Domain Motions in Ionotropic Glutamate Receptor GluR6 and the Hydrogen Bond Interactions that Switch Them On and Off

Autor: Rodney E. Versace, Marco Ceruso

Publikováno v: Biophysical Journal. 96(3)

Ionotropic glutamate receptors are tetrameric ligand-gated ion channels found in pre and postsynaptic cell membranes of the central nervous system. There are three pharmacological classes of ionotropic glutamate receptor, namely N-methyl-D-aspartate

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Expression and biophysical analysis of two double-transmembrane domain-containing fragments from a yeast G protein-coupled receptor

Autor: Heejung Kim, Jacqueline Englander, Marco Ceruso, Leah S. Cohen, Racha Estephan, Melinda Hauser, Oliver Zerbe, Boris Arshava, Jeffrey M. Becker, Fred Naider

Publikováno v: Biopolymers. 90(2)

Fragments of G protein-coupled receptors (GPCRs) are widely used as models to investigate these polytopic integral-membrane, signal-transducing molecules, but have proven difficult to prepare in quantities necessary for NMR analyses. We report on the

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https://pubmed.ncbi.nlm.nih.gov/18260136

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Thermodynamic Basis for Promiscuity and Selectivity in Protein-Protein Interactions: PDZ Domains, a Case Study

Autor: Nathalie Basdevant, Harel Weinstein, Marco Ceruso

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2006, 128 (39), pp.12766-12777
Journal of the American Chemical Society, American Chemical Society, 2006, 128 (39), pp.12766-12777. ⟨10.1021/ja060830y⟩

International audience; Like other protein−protein interaction domains, PDZ domains are involved in many key cellular processes. These processes often require that specific multiprotein complexes be assembled, a task that PDZ domains accomplish by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216edb47ff12ba4ed460ac8c1011cf3f
https://hal.archives-ouvertes.fr/hal-00157806

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Substituting isoserine for serine in the thrombin receptor activation peptide SFLLRN confers resistance to aminopeptidase M-induced cleavage and inactivation

Autor: Karen T. Springer, Marco Ceruso, Barry S. Coller, Lesley E. Scudder, Glenn D. Prestwich, Jeffery L. Kutok

Publikováno v: Journal of Biological Chemistry. 268:20741-20743

Peptides containing sequences derived from the new NH2 terminus of the seven-transmembrane domain thrombin receptor after thrombin cleavage can activate platelets directly. We recently demonstrated that such peptides are readily cleaved and inactivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c97e53b5e39e04cc5733473710232e00
https://doi.org/10.1016/s0021-9258(19)36844-9

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Obtaining Functionally Relevant Protein Structural Transitions Using a Combined Physics/Structure-Based Coarse-Grained Model

Autor: Marco Cavalli, Luisirene Hernandez, Marco Ceruso

Publikováno v: Biophysical Journal. 98:443a

The function of proteins is intimately tied to their dynamics and their ability to undergo structural transitions. These transitions are rare events, difficult to model computationally. Recently, we have developed ELNEDIN, a modeling approach that co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3124bbb6f55e87c5aca6d7a81f7fe24c
https://doi.org/10.1016/j.bpj.2009.12.2404

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Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M

Autor: Patrick E. Ward, Lesley E. Scudder, Glenn D. Prestwich, Karen T. Springer, Jeffery L. Kutok, Barry S. Coller, Marco Ceruso

Publikováno v: Biochemistry. 31(47)

Peptides derived from the recently identified thrombin receptor were tested for their ability to induce platelet aggregation in platelet-rich plasma. The 14 amino acid peptide identified as the new N-terminus after thrombin cleavage (T-14) and an 11

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https://pubmed.ncbi.nlm.nih.gov/1359906

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Coarse-grained Modeling And Simulation Of ErbB Receptors: Intramolecular Factors That Govern Outside-in Signaling And Activation

Autor: Marco Ceruso, Marco Cavalli

Publikováno v: Biophysical Journal. (3):367a-368a

Epidermal growth factor receptors (ErbB receptors) mediate a number of critical cellular processes including cell proliferation, differentiation, migration and apoptosis. These receptors have received a lot of attention because they have been implica

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