Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Marco Cavaco"'
Autor:
Marco Cavaco, Patrícia Fraga, Javier Valle, Ruben D. M. Silva, Lurdes Gano, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Blood–brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and reach the brain. Despite the importance of brain targeting in pharmacology, BBBpS are poorly characterized. Currently, their development relies on the e
Externí odkaz:
https://doaj.org/article/ff105247e7514a8eb2dac249aa0d9bfc
Autor:
Marco Cavaco, Clara Pérez-Peinado, Javier Valle, Ruben D.M. Silva, Lurdes Gano, João D.G. Correia, David Andreu, Miguel A.R.B. Castanho, Vera Neves
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116573- (2024)
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of commonly targeted receptors. Unspecific chemotherapy is currently the main therapeutic option, with poor results. Another major challenge is the frequent ap
Externí odkaz:
https://doaj.org/article/d7b51e84c4cd4946a87ae7a7b544b47e
Autor:
Ana S. André, Joana N. R. Dias, Sandra Aguiar, Sara Nogueira, Pedro Bule, Joana Inês Carvalho, João P. M. António, Marco Cavaco, Vera Neves, Soraia Oliveira, Gonçalo Vicente, Belmira Carrapiço, Berta São Braz, Barbara Rütgen, Lurdes Gano, João D. G. Correia, Miguel Castanho, Joao Goncalves, Pedro M. P. Gois, Solange Gil, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Antibody–drug conjugates (ADCs) are among the fastest-growing classes of therapeutics in oncology. Although ADCs are in the spotlight, they still present significant engineering challenges. Therefore, there is an urgent need to develop mor
Externí odkaz:
https://doaj.org/article/f9c1a085d74e4cbdaf2217e2c95385f7
Autor:
Ana S. André, Joana N. R. Dias, Sandra I. Aguiar, Ana Leonardo, Sara Nogueira, Joana D. Amaral, Célia Fernandes, Lurdes Gano, João D. G. Correia, Marco Cavaco, Vera Neves, Jorge Correia, Miguel Castanho, Cecília M. P. Rodrigues, Maria Manuela Gaspar, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionCancer is a major public health problem with over 19 million cases reported in 2020. Similarly to humans, dogs are also largely affected by cancer, with non-Hodgkin's lymphoma (NHL) among the most common cancers in both species. Comparati
Externí odkaz:
https://doaj.org/article/e1ae62f371ba4be582f085b5e995f720
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1349-1358 (2021)
Abstract Proteolytic instability is a critical limitation for peptide‐based products. Although significant efforts are devoted to stabilize sequences against proteases/peptidases in plasma/serum, such approaches tend to be rather empirical, unspeci
Externí odkaz:
https://doaj.org/article/adbdf920d04f4465842e78b226334880
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The emergence of antimicrobial resistance (AMR) is rapidly increasing and it is one of the significant twenty-first century’s healthcare challenges. Unfortunately, the development of effective antimicrobial agents is a much slower and complex proce
Externí odkaz:
https://doaj.org/article/81479eace440483aacdfad70c106de57
Autor:
Toni Todorovski, Diogo A. Mendonça, Lorena O. Fernandes-Siqueira, Christine Cruz-Oliveira, Giuseppina Guida, Javier Valle, Marco Cavaco, Fernanda I. V. Limas, Vera Neves, Íris Cadima-Couto, Sira Defaus, Ana Salomé Veiga, Andrea T. Da Poian, Miguel A. R. B. Castanho, David Andreu
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 738 (2022)
Viral disease outbreaks affect hundreds of millions of people worldwide and remain a serious threat to global health. The current SARS-CoV-2 pandemic and other recent geographically- confined viral outbreaks (severe acute respiratory syndrome (SARS),
Externí odkaz:
https://doaj.org/article/46403fb48abc4fbfb97dc626963881ce
Autor:
Marco Cavaco, Clara Pérez-Peinado, Javier Valle, Rúben D. M. Silva, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The characterization of biologically active peptides relies heavily on the study of their efficacy, toxicity, mechanism of action, cellular uptake, or intracellular location, using both in vitro and in vivo studies. These studies frequently depend on
Externí odkaz:
https://doaj.org/article/81a72c5e46694efeb31a6a682b0c2663
Autor:
Marco Cavaco, Patrícia Fraga, Javier Valle, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1863 (2021)
Breast cancer (BC) is the most commonly diagnosed cancer in women and one of the most common causes of cancer-related deaths. Despite intense research efforts, BC treatment still remains challenging. Improved drug development strategies are needed fo
Externí odkaz:
https://doaj.org/article/f01c0e8ba06d4b4390251fcc52ee3d03
Autor:
Sandra Isabel Aguiar, Joana N. R. Dias, Ana Santos André, Marta Lisete Silva, Diana Martins, Belmira Carrapiço, Miguel Castanho, João Carriço, Marco Cavaco, Maria Manuela Gaspar, Rui Jorge Nobre, Luís Pereira de Almeida, Soraia Oliveira, Lurdes Gano, João D. G. Correia, Carlos Barbas, João Gonçalves, Vera Neves, Frederico Aires-da-Silva
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1598 (2021)
A major bottleneck in the successful development of central nervous system (CNS) drugs is the discovery and design of molecules that can cross the blood-brain barrier (BBB). Nano-delivery strategies are a promising approach that take advantage of nat
Externí odkaz:
https://doaj.org/article/d5051f93f2de446f9499ae1e868ed9eb