Výsledky vyhledávání - "Marco C. Betist"

Akademický článek

An optimized dissociation protocol for FACS-based isolation of rare cell types from Caenorhabditis elegans L1 larvae

Autor: Euclides E. Fernandes Póvoa, Annabel L.P. Ebbing, Marco C. Betist, Christa van der Veen, Hendrik C. Korswagen

Publikováno v: MethodsX, Vol 7, Iss , Pp 100922- (2020)

Single-cell isolation and transcriptomic analysis of a specific cell type or tissue offers the possibility of studying cell function and heterogeneity in time-dependent processes with remarkable resolution. The reduced tissue complexity and highly st

Externí odkaz: https://doaj.org/article/53dc6326873046738fbd77d8ca13b375

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Akademický článek

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

Autor: Ian J. McGough, Reinoud E. A. de Groot, Adam P. Jellett, Marco C. Betist, Katherine C. Varandas, Chris M. Danson, Kate J. Heesom, Hendrik C. Korswagen, Peter J. Cullen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C. elegans and human cells, SNX3-retromer requires an evo

Externí odkaz: https://doaj.org/article/d470221d33d847238609773f477f4c71

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Akademický článek

A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension

Autor: Paul B. Essers, Julie Nonnekens, Yvonne J. Goos, Marco C. Betist, Marjon D. Viester, Britt Mossink, Nico Lansu, Hendrik C. Korswagen, Rob Jelier, Arjan B. Brenkman, Alyson W. MacInnes

Publikováno v: Cell Reports, Vol 10, Iss 3, Pp 339-345 (2015)

The biogenesis of ribosomes and their coordination of protein translation consume an enormous amount of cellular energy. As such, it has been established that the inhibition of either process can extend eukaryotic lifespan. Here, we used next-generat

Externí odkaz: https://doaj.org/article/7a0ee984de1c42b8b1b632d74737885c

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Akademický článek

Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism

Autor: Gerdine J Stout, Edwin C A Stigter, Paul B Essers, Klaas W Mulder, Annemieke Kolkman, Dorien S Snijders, Niels J F van den Broek, Marco C Betist, Hendrik C Korswagen, Alyson W MacInnes, Arjan B Brenkman

Publikováno v: Molecular Systems Biology, Vol 9, Iss 1, Pp 1-13 (2013)

Abstract Mutations in the daf‐2 gene of the conserved Insulin/Insulin‐like Growth Factor (IGF‐1) pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is completely suppressed by deletion of Forkhead transcription f

Externí odkaz: https://doaj.org/article/d5f1cc4c270e464b839147f717d3960c

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Spatial transcriptomics of the nematode Caenorhabditis elegans using RNA tomography

Autor: Jonas Mars, Hendrik C. Korswagen, Marco C. Betist, Erik S. Schild, Annabel Ebbing, Judith Vivié

Publikováno v: STAR Protocols, Vol 2, Iss 2, Pp 100411-(2021)
STAR Protocols
STAR protocols, 2(2). Cell Press

Summary RNA tomography or tomo-seq combines mRNA sequencing and cryo-sectioning to spatially resolve gene expression. We have adapted this method for the nematode Caenorhabditis elegans to generate anteroposterior gene expression maps at near-cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2c42f63eddefd74c2c67ec0758fd1b
http://www.sciencedirect.com/science/article/pii/S2666166721001180

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Spatial Transcriptomics of C. elegans Males and Hermaphrodites Identifies Sex-Specific Differences in Gene Expression Patterns

Autor: Eugene Berezikov, Hendrik C. Korswagen, Bastiaan Spanjaard, Jan Philipp Junker, Marco C. Betist, Annabel Ebbing, Ábel Vértesy, Alexander van Oudenaarden

Publikováno v: Developmental Cell, 47(6), 801. Cell Press
Developmental Cell, 47(6), 801-813. CELL PRESS
Developmental Cell, 47(6), 801-813.e6. Cell Press

To advance our understanding of the genetic programs that drive cell and tissue specialization, it is necessary to obtain a comprehensive overview of gene expression patterns. Here, we have used spatial transcriptomics to generate high-resolution, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b96684d383025fe98c14f65776e4b7
https://hdl.handle.net/11370/ac004c12-2fc2-47be-8a15-8c38badcb7e2

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Partially overlapping guidance pathways focus the activity of UNC-40/DCC along the anteroposterior axis of polarizing neuroblasts

Autor: Teije C. Middelkoop, Hendrik C. Korswagen, Marco C. Betist, Eduard Bodewes, Annabel Ebbing

Publikováno v: Development (Cambridge), 146(18). Company of Biologists Ltd
Development

Directional migration of neurons and neuronal precursor cells is a central process in nervous system development. In the nematode C. elegans, the two Q neuroblasts polarize and migrate in opposite directions along the anteroposterior body axis. Sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d429d92d2a0bff3ce33b79339002fdb
https://pure.knaw.nl/portal/en/publications/cdc5ada9-e5b1-4413-a308-613d3cec1a98

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The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism

Autor: Hendrik C. Korswagen, Tomasz Witold Radaszkiewicz, Lorenzo Rella, Vítězslav Bryja, Tomáš Gybel, Marco C. Betist, Remco A. Mentink

Publikováno v: PLoS Genetics, 14(12). Public Library of Science
PLoS Genetics
PLoS Genetics, Vol 14, Iss 12, p e1007840 (2018)

Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration. Studies in vertebrate model systems have suggested that Vangl and Pk may also inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978ef3b3a57b08bfd809b49241629ee
https://dspace.library.uu.nl/handle/1874/377570

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