SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

Autor: Ian J. McGough, Reinoud E. A. de Groot, Adam P. Jellett, Marco C. Betist, Katherine C. Varandas, Chris M. Danson, Kate J. Heesom, Hendrik C. Korswagen, Peter J. Cullen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C. elegans and human cells, SNX3-retromer requires an evo

Externí odkaz: https://doaj.org/article/d470221d33d847238609773f477f4c71

A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension

Autor: Paul B. Essers, Julie Nonnekens, Yvonne J. Goos, Marco C. Betist, Marjon D. Viester, Britt Mossink, Nico Lansu, Hendrik C. Korswagen, Rob Jelier, Arjan B. Brenkman, Alyson W. MacInnes

Publikováno v: Cell Reports, Vol 10, Iss 3, Pp 339-345 (2015)

The biogenesis of ribosomes and their coordination of protein translation consume an enormous amount of cellular energy. As such, it has been established that the inhibition of either process can extend eukaryotic lifespan. Here, we used next-generat

Externí odkaz: https://doaj.org/article/7a0ee984de1c42b8b1b632d74737885c

Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila.

Autor: Chandan Bhambhani, Aditi J Ravindranath, Remco A Mentink, Mikyung V Chang, Marco C Betist, Yaxuan X Yang, Sandhya P Koushika, Hendrik C Korswagen, Ken M Cadigan

Publikováno v: PLoS Genetics, Vol 10, Iss 2, p e1004133 (2014)

Regulation of gene expression by signaling pathways often occurs through a transcriptional switch, where the transcription factor responsible for signal-dependent gene activation represses the same targets in the absence of signaling. T-cell factors

Externí odkaz: https://doaj.org/article/8a64b1389d3949cba82f92d6ddde5849

Spatial Transcriptomics of C. elegans Males and Hermaphrodites Identifies Sex-Specific Differences in Gene Expression Patterns

Autor: Eugene Berezikov, Hendrik C. Korswagen, Bastiaan Spanjaard, Jan Philipp Junker, Marco C. Betist, Annabel Ebbing, Ábel Vértesy, Alexander van Oudenaarden

Publikováno v: Developmental Cell, 47(6), 801. Cell Press
Developmental Cell, 47(6), 801-813. CELL PRESS
Developmental Cell, 47(6), 801-813.e6. Cell Press

To advance our understanding of the genetic programs that drive cell and tissue specialization, it is necessary to obtain a comprehensive overview of gene expression patterns. Here, we have used spatial transcriptomics to generate high-resolution, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b96684d383025fe98c14f65776e4b7
https://hdl.handle.net/11370/ac004c12-2fc2-47be-8a15-8c38badcb7e2

The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism

Autor: Hendrik C. Korswagen, Tomasz Witold Radaszkiewicz, Lorenzo Rella, Vítězslav Bryja, Tomáš Gybel, Marco C. Betist, Remco A. Mentink

Publikováno v: PLoS Genetics, 14(12). Public Library of Science
PLoS Genetics
PLoS Genetics, Vol 14, Iss 12, p e1007840 (2018)

Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration. Studies in vertebrate model systems have suggested that Vangl and Pk may also inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978ef3b3a57b08bfd809b49241629ee
https://dspace.library.uu.nl/handle/1874/377570