Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Marco Bolis"'
Autor:
Alessia Cacciatore, Dheeraj Shinde, Carola Musumeci, Giada Sandrini, Luca Guarrera, Domenico Albino, Gianluca Civenni, Elisa Storelli, Simone Mosole, Elisa Federici, Alessio Fusina, Marta Iozzo, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Marco Bolis, Carlo V. Catapano, Giuseppina M. Carbone
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Castration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify methionine adenosyltransferase 2a (MAT2A) as a critical driver of the androgen-in
Externí odkaz:
https://doaj.org/article/724f72ec506f4c06aa1670dd1c8ab69a
Autor:
Michela Chiappa, Alessandra Decio, Luca Guarrera, Ilaria Mengoli, Anju Karki, Divora Yemane, Carmen Ghilardi, Eugenio Scanziani, Simone Canesi, Maria C. Barbera, Ilaria Craparotta, Marco Bolis, Robert Fruscio, Chiara Grasselli, Tommaso Ceruti, Massimo Zucchetti, Jesse C. Patterson, Robin A. Lu, Micheal B. Yaffe, Maya Ridinger, Giovanna Damia, Federica Guffanti
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-11 (2024)
Abstract Occurrence of resistance to olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) approved in ovarian carcinoma, has already been shown in clinical settings. Identifying combination treatments to sensitize tumor cells and/or overc
Externí odkaz:
https://doaj.org/article/e764c5cee5904b2eb21c09d037806e4a
Autor:
Torben Redmer, Martin Raigel, Christina Sternberg, Roman Ziegler, Clara Probst, Desiree Lindner, Astrid Aufinger, Tanja Limberger, Karolina Trachtova, Petra Kodajova, Sandra Högler, Michaela Schlederer, Stefan Stoiber, Monika Oberhuber, Marco Bolis, Heidi A. Neubauer, Sara Miranda, Martina Tomberger, Nora S. Harbusch, Ines Garces de los Fayos Alonso, Felix Sternberg, Richard Moriggl, Jean-Philippe Theurillat, Boris Tichy, Vojtech Bystry, Jenny L. Persson, Stephan Mathas, Fritz Aberger, Birgit Strobl, Sarka Pospisilova, Olaf Merkel, Gerda Egger, Sabine Lagger, Lukas Kenner
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated as potential oncogeni
Externí odkaz:
https://doaj.org/article/adefb22c8cb94d6696ce31c1da5a32f5
Autor:
Noemi Puccio, Gloria Manzotti, Elisabetta Mereu, Federica Torricelli, Domenica Ronchetti, Michela Cumerlato, Ilaria Craparotta, Laura Di Rito, Marco Bolis, Valentina Traini, Veronica Manicardi, Valentina Fragliasso, Yvan Torrente, Nicola Amodio, Niccolò Bolli, Elisa Taiana, Alessia Ciarrochi, Roberto Piva, Antonino Neri
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Multiple myeloma (MM) is a dreadful disease, marked by the uncontrolled proliferation of clonal plasma cells (PCs) within the bone marrow (BM). MM is characterized by a highly heterogeneous clinical and molecular background, supported by severe genom
Externí odkaz:
https://doaj.org/article/14498b0f3bfd45faa9f5c4dd0eecdaa1
Autor:
Luca Guarrera, Mami Kurosaki, Silvio-Ken Garattini, Maurizio Gianni’, Gianpiero Fasola, Luca Rossit, Michele Prisciandaro, Maria Di Bartolomeo, Marco Bolis, Paola Rizzo, Claudia Nastasi, Marika Foglia, Adriana Zanetti, Gabriela Paroni, Mineko Terao, Enrico Garattini
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-20 (2023)
Abstract Background Gastric-cancer is a heterogeneous type of neoplastic disease and it lacks appropriate therapeutic options. There is an urgent need for the development of innovative pharmacological strategies, particularly in consideration of the
Externí odkaz:
https://doaj.org/article/afa7a8af41994fcf9273d86fa409c526
Autor:
David Legouis, Anna Rinaldi, Daniele Malpetti, Gregoire Arnoux, Thomas Verissimo, Anna Faivre, Francesca Mangili, Andrea Rinaldi, Lorenzo Ruinelli, Jerome Pugin, Solange Moll, Luca Clivio, Marco Bolis, Sophie de Seigneux, Laura Azzimonti, Pietro E. Cippà
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109271- (2024)
Summary: The application of single-cell technologies in clinical nephrology remains elusive. We generated an atlas of transcriptionally defined cell types and cell states of human kidney disease by integrating single-cell signatures reported in the l
Externí odkaz:
https://doaj.org/article/04cc14f1af314aec954efa5b5e1216aa
Autor:
Maurizio Callari, Martina Sola, Claudia Magrin, Andrea Rinaldi, Marco Bolis, Paolo Paganetti, Luca Colnaghi, Stéphanie Papin
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Tau (MAPT) is a microtubule-associated protein causing common neurodegenerative diseases or rare inherited frontotemporal lobar degenerations. Emerging evidence for non-canonical functions of Tau in DNA repair and P53 regulation suggests its
Externí odkaz:
https://doaj.org/article/e54820e58dc64400aa4078dd59eb5a12
Autor:
Claudia Magrin, Martina Bellafante, Martina Sola, Ester Piovesana, Marco Bolis, Luciano Cascione, Sara Napoli, Andrea Rinaldi, Stéphanie Papin, Paolo Paganetti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Progressive Tau deposition in neurofibrillary tangles and neuropil threads is the hallmark of tauopathies, a disorder group that includes Alzheimer’s disease. Since Tau is a microtubule-associated protein, a prevalent concept to expla
Externí odkaz:
https://doaj.org/article/38cfccd2d5e4432fafa2b6cbdfe9a046
Autor:
Francesca Donnaloja, Luca Izzo, Marzia Campanile, Simone Perottoni, Lucia Boeri, Francesca Fanizza, Lorenzo Sardelli, Emanuela Jacchetti, Manuela T. Raimondi, Laura Di Rito, Ilaria Craparotta, Marco Bolis, Carmen Giordano, Diego Albani
Publikováno v:
APL Bioengineering, Vol 7, Iss 3, Pp 036117-036117-14 (2023)
We developed an innovative millifluidic organ-on-a-chip device, named MINERVA 2.0, that is optically accessible and suitable to serial connection. In the present work, we evaluated MINERVA 2.0 as millifluidic gut epithelium-on-a-chip by using computa
Externí odkaz:
https://doaj.org/article/95f60ffb30dd4e608a18681b7edbac2e
Autor:
Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D’Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva, Hasan Ali Kabakci, Svenja Godbersen, Andrea Alimonti, Gerald Schwank, Markus Stoffel
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107368- (2023)
Summary: Although dietary fructose is associated with an elevated risk for pancreatic cancer, the underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, is a driver of PDAC de
Externí odkaz:
https://doaj.org/article/92e4cfa9282e4da99d2e1ee03163bd9e