Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Marco Beauséjour"'
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Histone Deacetylase Inhibition Impairs Normal Intestinal Cell Proliferation and Promotes Specific Gene Expression
Autor: Jean-François Beaulieu, Aline Simoneau, Amel Guezguez, Marco Beauséjour, Alireza Roostaee, Emile Levy, Pierre H. Vachon
Publikováno v: Journal of Cellular Biochemistry
Mechanisms that maintain proliferation and delay cell differentiation in the intestinal crypt are not yet fully understood. We have previously shown the implication of histone methylation in the regulation of enterocytic differentiation. In this stud
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4826710dfe413717d9af1582dd61cc0a
http://europepmc.org/articles/PMC5014201
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3
Involvement of the Integrin α1β1 in the Progression of Colorectal Cancer
Autor: Blanche Sénicourt, Marco Beauséjour, Salah Boudjadi, Gérald Bernatchez, Jean-François Beaulieu, Pierre H. Vachon, Julie Carrier
Publikováno v: Cancers; Volume 9; Issue 8; Pages: 96
Cancers
Cancers, Vol 9, Iss 8, p 96 (2017)
Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling that participate in the regulation of cell shape, adhesion, migration, survival and proliferation. The integrin α1β1 is known to be involved in RAS/ERK p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038d44a5022486f5300990f1dd142fea
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4
Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes
Autor: Marie-Josée Demers, Véronique Bouchard, Pierre H. Vachon, Charlène Harnois, Sonya Thibodeau, Marco Beauséjour, Dominique Noël, Jean-François Beaulieu
Publikováno v: Apoptosis
In human intestinal epithelial crypt (HIEC) cells, the PI3-K/Akt-1 pathway is crucial for the promotion of cell survival and suppression of anoikis. Class I PI3-K consists of a complex formed by a catalytic (C) and regulatory (R) subunit. Three R (p8
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048b8f0129dc0c27e8067fe25beb30de
https://doi.org/10.1007/s10495-012-0713-6
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5
Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells
Autor: Lorraine J. Gudas, Marco Beauséjour, Jean-François Beaulieu, Mavee Witherspoon, Yannick D. Benoit, Kristian B. Laursen, Steven M. Lipkin, Amel Guezguez
Colorectal cancer is among the leading causes of cancer death in the USA. The polycomb repressive complex 2 (PRC2), including core components SUZ12 and EZH2, represents a key epigenetic regulator of digestive epithelial cell physiology and was previo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489b638941f4ef7c980a840092fcb1fe
https://europepmc.org/articles/PMC3880229/
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6
Abstract 5090: α1β1 is pro-proliferative and promigratory integrin and its expression is upregulated by the MYC oncogenic factor in colorectal cancer
Autor: Blanche Sénicourt, Pierre-Henri Vachon, Jean-François Beaulieu, Marco Beauséjour, Gérald Bernatchez, Julie Carrier, Salah Boudjadi
Publikováno v: Cancer Research. 76:5090-5090
Background Colorectal cancer (CRC) is a multi-step process that involves successive mutation, epigenetic alteration and gene dysregulation. Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling and participate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3e09ded2647eec52b159fa77b8c86a3
https://doi.org/10.1158/1538-7445.am2016-5090
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7
Suppression of anoikis in human intestinal epithelial cells: differentiation state-selective roles of α2β1, α3β1, α5β1, and α6β4 integrins
Autor: Véronique Bouchard, Rémy Gauthier, Marco Beauséjour, Sonya Thibodeau, Marie-Josée Demers, Pierre H. Vachon, Jean-François Beaulieu
Publikováno v: BMC Cell Biology
Background Regulation of anoikis in human intestinal epithelial cells (IECs) implicates differentiation state-specific mechanisms. Human IECs express distinct repertoires of integrins according to their state of differentiation. Therefore, we investi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a367fd1b7117ae7e5fdbcc4370c31f
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8
Mitochondria in Focus: Targeting the Cell-Death Mechanism
Autor: Giuseppina Votta, Ferdinando Chiaradonna, Humberto De Vitto, Roberta Palorini
Publikováno v: Apoptosis and Beyond
An understanding of the mechanism of apoptosis has received a substantial amount of interest over the past decades. It is evident from many works that mitochondria play a pivotal role in keeping cell homeostasis in both physiological and pathological
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd882ad23893057c344bf178a12c29d
https://doi.org/10.1002/9781119432463.ch2
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