NRF2 is essential for adaptative browning of white adipocytes

Autor: Marco Bauzá-Thorbrügge, Eduard Peris, Shabnam Zamani, Peter Micallef, Alexandra Paul, Stefano Bartesaghi, Anna Benrick, Ingrid Wernstedt Asterholm

Publikováno v: Redox Biology, Vol 68, Iss , Pp 102951- (2023)

White adipose tissue browning, defined by accelerated mitochondrial metabolism and biogenesis, is considered a promising mean to treat or prevent obesity-associated metabolic disturbances. We hypothesize that redox stress acutely leads to increased p

Externí odkaz: https://doaj.org/article/61b774a4c0b54b2993fdc76ddce133b4

17β-estradiol ameliorates lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance

Autor: Miquel Sbert-Roig, Andrea Morán-Costoya, Ana M. Proenza, Bel M. Galmés-Pascual, Magdalena Gianotti, Adamo Valle, Isabel Lladó, Melanie Raquel Martínez-Cignoni, Marco Bauzá-Thorbrügge

Publikováno v: Free Radical Biology and Medicine. 150:148-160

The prevalence and severity of nonalcoholic fatty liver disease (NAFLD) is higher in men and postmenopausal women compared to premenopausal women, suggesting a protective role for ovarian hormones. Diet-induced obesity and fatty acids surplus promote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b860048a6f4c3716f498f8c73d1a89bb
https://doi.org/10.1016/j.freeradbiomed.2020.02.016

Adipose Tissue—Breast Cancer Crosstalk Leads to Increased Tumor Lipogenesis Associated with Enhanced Tumor Growth

Autor: Eduard Peris, Ingrid Wernstedt Asterholm, Belén Chanclón, Peter Micallef, Milica Vujičić, C. Joakim Ek, Yanling Wu, Marco Bauzá-Thorbrügge

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11881, p 11881 (2021)

We sought to identify therapeutic targets for breast cancer by investigating the metabolic symbiosis between breast cancer and adipose tissue. To this end, we compared orthotopic E0771 breast cancer tumors that were in direct contact with adipose tis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad003cdf8cecdff61b80203755964454

GPER mediates the effects of 17β-estradiol in cardiac mitochondrial biogenesis and function

Autor: Bel M. Galmés-Pascual, Francisco J. García-Palmer, Gabriela Capllonch-Amer, Magdalena Gianotti, Isabel Lladó, Miquel Sbert-Roig, Marco Bauzá-Thorbrügge, Ana M. Proenza

Publikováno v: Molecular and Cellular Endocrinology. 420:116-124

Considering the sexual dimorphism described in cardiac mitochondrial function and oxidative stress, we aimed to investigate the role of 17β-estradiol (E2) in these sex differences and the contribution of E2 receptors to these effects. As a model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2d7f277aa3f0d2efcf3f0a1951a45b
https://doi.org/10.1016/j.mce.2015.11.027

Antioxidant peroxiredoxin 3 expression is regulated by 17beta-estradiol in rat white adipose tissue

Autor: Isabel Lladó, Magdalena Gianotti, Miquel Sbert-Roig, Ana M. Proenza, Marco Bauzá-Thorbrügge, Bel M. Galmés-Pascual, Francisco J. García-Palmer

Publikováno v: The Journal of steroid biochemistry and molecular biology. 172

Peroxiredoxin 3 (PRX3) plays a role as a regulator of the adipocyte mitochondrial function due to its antioxidant activity. We have previously reported the existence of a sexual dimorphism in the mitochondrial oxidative stress status of many rat tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4757156ef5c6155b7b246ad35c1d627b
https://pubmed.ncbi.nlm.nih.gov/28529127