Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marco A. Pineyro"'
Autor:
Chahrzad Montrose-Rafizadeh, Andrzej M. Janczewski, Steven J. Sollott, Marco A. Pineyro, Yihong Wang, Jie Zhou, Josephine M. Egan
Publikováno v:
Journal of Cellular Physiology. 181:470-478
In this study, AR42J pancreatic acinar cells were used to investigate if glucagon-like peptide-1 (GLP-1) or glucagon might influence amylase release and acinar cell function. We first confirmed the presence of GLP-1 receptors on AR42J cells by revers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef6399d77139d859e410d527f9c11dc7
https://doi.org/10.1002/(sici)1097-4652(199912)181:3<470::aid-jcp11>3.0.co
https://doi.org/10.1002/(sici)1097-4652(199912)181:3<470::aid-jcp11>3.0.co
Autor:
Marco A. Pineyro, Josephine M. Egan, Máire E. Doyle, Xiaolin Wang, Jie Zhou, Catherine M. Cahill
Publikováno v:
Endocrinology. 140:4904-4907
Glucagon-like peptide-1 (GLP-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, GLUT2 and glucokinase genes. The latter are also regulated by the PDX-1 homeoprotein. We investigated the possibility that GLP-1 may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a33c6a535818e0e9efcf59913e500dd
https://doi.org/10.1210/endo.140.10.7158
https://doi.org/10.1210/endo.140.10.7158
Publikováno v:
Endocrinology. 127:2236-2240
Glucagon-stimulated adenylyl cyclase activity has been shown to change in liver membranes manipulated to alter either their fatty acid composition or fluidity. We examined whether membrane alterations induced by dietary manipulation affected receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c316a0962e419701e79202af9938591
https://doi.org/10.1210/endo-127-5-2236
https://doi.org/10.1210/endo-127-5-2236
Exendin-4 (EX-4), a long acting agonist of GLP-1, induces an endocrine phenotype in Capan-1 cells. Under culture conditions which include serum, approximately 10% of the cells contain insulin and glucagon. When exposed to EX-4 (0.1 nM, up to 5 days),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8677068e7e2eb12f99f64eb542aed5d
https://zenodo.org/record/1229235
https://zenodo.org/record/1229235
Publikováno v:
Diabetes. 48(12)
In this article, we show that glucagon-like peptide 1 (GLP-1) can induce AR42J cells to differentiate into insulin, pancreatic polypeptide, and glucagon-positive cells. In their natural state, these cells, which are derived from a chemically induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fc581d5753e051530847769a33512f
https://pubmed.ncbi.nlm.nih.gov/10580424
https://pubmed.ncbi.nlm.nih.gov/10580424
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 613:229-237
Stimulation of adenylate cyclase by high concentrations of Mg 2+ has been attributed to either occupation of a divalent cation site on the enzyme or Mg 2+ binding of inhibitory species of uncomplexed ATP. However, the stimulation of adenylate cyclase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f96da9efa4ce8c50b5ab241937b5de
https://doi.org/10.1016/0005-2744(80)90209-0
https://doi.org/10.1016/0005-2744(80)90209-0
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 632:11-25
The effects of inorganic salts on adenylate cyclase activities were studied in rat liver homogenates, particulates, and purified membranes. Na+ salts of N-3, NO-2, S2O32-, SO42-, and non-F- halides stimulated homogenates by a maximum of 2---5-fold; h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af3050cb8ac3ca24c5dbd39c5f5c867
https://doi.org/10.1016/0304-4165(80)90245-7
https://doi.org/10.1016/0304-4165(80)90245-7
Publikováno v:
Biochemical and Biophysical Research Communications. 61:781-787
Adenylyl cyclase of rat liver and fat cells is activated by chloride, bromide, and iodide in addition to fluoride, previously believed to be uniquely effective among the halide anions. Liver homogenates are activated approximately 6 fold by fluoride
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4ced6dbf750648803b9f8fd260300b
https://doi.org/10.1016/0006-291x(74)91025-0
https://doi.org/10.1016/0006-291x(74)91025-0
Publikováno v:
Journal of Biological Chemistry. 259:7038-7044
GDP regulation of basal and receptor-mediated catecholamine-sensitive human fat cell adenylate cyclase was studied using purified plasma membrane preparations and assay conditions selected to minimize conversion of GDP to GTP. Under ordinary assay co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be3102e6849233491753ad5de5a04720
https://doi.org/10.1016/s0021-9258(17)39834-4
https://doi.org/10.1016/s0021-9258(17)39834-4
Autor:
Elizabeth M. Dax, Michael S. Katz, Marco A. Pineyro, Thomas M. Kelly, Robert I. Gregerman, John S. Partilla
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 60:900-909
The adenylate cyclase of an adrenocortical carcinoma of the rat is activated not only by ACTH but also by beta-adrenergic agonists, which bind to ectopic beta-adrenergic receptors not present in normal rat adrenal cortex. Previous reports examining p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24630bf7b611d0ce2866a8b4aff1e518
https://doi.org/10.1210/jcem-60-5-900
https://doi.org/10.1210/jcem-60-5-900