Výsledky vyhledávání - "Marco A. Coccia"

Prolonged neutropenia in a novel mouse granulocyte colony-stimulating factor neutralizing auto-immunoglobulin G mouse model

Autor: Marco A. Coccia, Patricia McElroy, Graham Molineux, Weston Sutherland, Juan Del Castillo, John E. Tarpley, Jeanne Pistillo, Cynthia Hartley

Publikováno v: Experimental Hematology. 29:59-67

Therapeutic use of recombinant human cytokines in humans can result in the generation of drug-specific antibodies. To predetermine the maximum potential effects of a granulocyte colony-stimulating factor (G-CSF) neutralizing auto-immunoglobulin G (au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c1488dfa4ab16d4c8dc787d3342e9b
https://doi.org/10.1016/s0301-472x(00)00614-7

Zobrazit plný text záznamu

Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS

Autor: Michael G. Sonnenberg, Kent Miner, Ariela Hui, Raffi Manoukian, John M. Delaney, Ming Zhang, Marco A. Coccia, Hong Han, Tom Horan, John Whoriskey, Jeanne Pistillo, Steven Kiyoshi Yoshinaga, Sanjay D. Khare, Tianang Dai, Tom Boone, David W. Brankow, Tadahiko Kohno

Publikováno v: International Immunology. 12:1439-1447

Optimal T cell activation requires the interactions of co-stimulatory molecules, such as those in the CD28 and B7 protein families. Recently, we described the co-stimulatory properties of the murine ligand to ICOS, which we designated as B7RP-1. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862e5ff3cec520f50fd1e247ea32e879
https://doi.org/10.1093/intimm/12.10.1439

Zobrazit plný text záznamu

T-cell co-stimulation through B7RP-1 and ICOS

Publikováno v: Nature. 402:827-832

T-cell activation requires co-stimulation through receptors such as CD28 and antigen-specific signalling through the T-cell antigen receptor. Here we describe a new murine costimulatory receptor-ligand pair. The receptor, which is related to CD28 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff4f55ca403f245339d6b589e29d12e
https://doi.org/10.1038/45582

Zobrazit plný text záznamu

High Titer, Prostate Specific Antigen-Specific Human IgG Production byhu-PBL-SCID Mice Immunized with Antigen-Mouse IgG2a Complex-Pulsed Autologous Dendritic Cells

Autor: Marco A. Coccia, Peter Brams

Publikováno v: The Journal of Immunology. 161:5772-5780

We report here that immunization of human PBMC reconstituted SCID mice (hu-PBL-SCID mice) with in vitro cultured autologous dendritic cells (DC) pulsed with prostate specific antigen (PSA) complexed to a PSA-specific mouse IgG2a (PSA-IgG2a) consisten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c65c5099457e06b8821834026bd081a0
https://doi.org/10.4049/jimmunol.161.10.5772

Zobrazit plný text záznamu

Human IL-6 Enhances Human Lymphocyte Engraftment and Activation but not Human Antibody Production in SCIDhu PBL Mice

Autor: Christine L. Knott, Marco A. Coccia, Kristine Kuus-Reichel, Suzanne J. Weeks

Publikováno v: Immunobiology. 198:396-407

The SCIDhu PBL model of human Ig production was modified by using human interleukin-6 (hIL-6) secreting tumors for continuous hIL-6 production, in vivo . On day one, SCID mice were injected subcutaneously with 200 µl PBS (control mice), 10 4 SP2/0-A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd865730d73f5a431d760317a19b315
https://doi.org/10.1016/s0171-2985(98)80048-x

Zobrazit plný text záznamu

Novel erythropoiesis stimulating protein (darbepoetin alfa) alleviates anemia associated with chronic inflammatory disease in a rodent model

Autor: Keegan Cooke, Juan Del Castillo, G Stoney, Jeanne Pistillo, Marco A. Coccia, Graham Molineux, Diane Duryea, John E. Tarpley

Publikováno v: Experimental hematology. 29(10)

Objective We developed a rodent model of noninfectious systemic inflammation to examine the pathogenesis of the associated anemia of chronic disorders (ACD), to evaluate the similarity of this ACD model to human ACD, and to evaluate the potential eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e0b4db2c4618a58f0d3d3458645888
https://pubmed.ncbi.nlm.nih.gov/11602322

Zobrazit plný text záznamu

THU0040 Anaemia of chronic disease (acd) in a rodent model is similar to human acd and can be alleviated by aranesp treatment

Autor: J. Del Castillo, Marco A. Coccia, Jeanne Pistillo, Graham Molineux, Keegan Cooke, G Stoney, Weston Sutherland

Publikováno v: Speaker abstracts 2001.

Background We previously reported that ARANESP™ alleviates ACD in a rodent model of peptidoglycan-polysaccharide polymer (PG-APS) mediated inflammation. We report here the further characterisation of this model and the effects of ARANESP™ treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dca32bc1cf08df1f36a23e45324a21c
https://doi.org/10.1136/annrheumdis-2001.837

Zobrazit plný text záznamu

Generation of murine monoclonal antibodies in serum-free medium

Autor: Ru-Shya Liu, Kristine Kuus-Reichel, Janice K. Payne, Danh Ta, Marco A. Coccia

Publikováno v: Hybridoma. 17(1)

Traditional hybridoma fusion technology requires complete medium with serum supplements to support the growth of hybridoma cells. Serum is also required for subcloning of hybridoma cells to support low density cell growth. IL-6 has been shown to enha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16aea3bcbe6aedffd2dceed616d3af3
https://pubmed.ncbi.nlm.nih.gov/9523240

Zobrazit plný text záznamu

Characterization of MDX-1401, a Human Anti-CD30 Antibody with Enhanced Effector Function, for Therapy of Malignant Lymphoma

Autor: Mohan Srinivasan, Albert Assad, Robert F. Graziano, Sharline Chen, David Passmore, Michelle R. Kuhne, Ben Preston, Pina M. Cardarelli, Tseng-Hui Chen, Cristina Loomis, David J. King, Marco A. Coccia, Alison Witte, Jie Liu, Amelia Black

Publikováno v: Blood. 112:1580-1580

Therapeutic monoclonal antibodies kill target cells by multiple mechanisms including antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent phagocytosis (ADP), complement-dependent cytotoxicity (CDC), and direct induction of apoptosis. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b21e57696d144d8ea775bbf87f200deb
https://doi.org/10.1182/blood.v112.11.1580.1580

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání