Výsledky vyhledávání - "Marco A Chivalan"

Abstract P1-16-05: Oraxol + Encequidar (OPac+E) vs IV paclitaxel (IVPac) in the treatment of patients with metastatic breast cancer (mBC) (Study KX-ORAX-001): Subgroup survival analysis of patients with hepatic dysfunction

Autor: Gerardo Umanzor, Hope S Rugo, Francisco J Barrios, R H Vasallo, Marco A Chivalan, S Bejarano, Julio Roberto Ramirez, Luis Fein, R D Kowalyszyn, D L Cutler, D Kramer, H Wang, R MF Kwan

Publikováno v: Cancer Research. 82:P1-16

Background: IVPac is widely used to treat patients with breast cancer. oPac+E is oral paclitaxel in combination with Encequidar, an oral, minimally absorbed, specific p-glycoprotein inhibitor that enables the absorption of oral paclitaxel. Results of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d38383fb942a80deb271ccf0db35570
https://doi.org/10.1158/1538-7445.sabcs21-p1-16-05

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Open-Label, Randomized, Multicenter, Phase III Study Comparing Oral Paclitaxel Plus Encequidar Versus Intravenous Paclitaxel in Patients With Metastatic Breast Cancer

Autor: Hope S, Rugo, Gerardo A, Umanzor, Francisco J, Barrios, Rosa H, Vasallo, Marco A, Chivalan, Suyapa, Bejarano, Julio R, Ramírez, Luis, Fein, Ruben D, Kowalyszyn, E Douglas, Kramer, Hui, Wang, Min-Fun R, Kwan, David L, Cutler

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 41(1)

PURPOSE Intravenous paclitaxel (IVpac) is complicated by neuropathy and requires premedication to prevent hypersensitivity-type reactions. Paclitaxel is poorly absorbed orally; encequidar (E), a novel P-glycoprotein pump inhibitor, allows oral absorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f1080421c72b6cc7509f5d3d50bf43
https://pubmed.ncbi.nlm.nih.gov/35858154

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KX-ORAX-001: An open label, randomized, multicenter, phase III registrational study to determine the safety, tolerability, and tumor response of oraxol (HM30181A + oral paclitaxel) and its comparability to IV paclitaxel in patients with metastatic breast cancer (MBC)

Autor: T Moore, F J Barrios, Julio Roberto Ramirez Velasquez, Marco Antonio Chivalan Castro, Rosa Haydee Vassallo, David M. Cutler, Luis Fein, Douglas Kramer, Ruben Dario Kowalyszyn, Rudolf Kwan, J Goldfinch, Gerardo Antonio Umanzor Funez, Suyapa A. Bejarano

Publikováno v: Journal of Clinical Oncology. 37:TPS1116-TPS1116

TPS1116 Background: Paclitaxel is used in multiple cancer types including the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within six months of adjuvant chemotherapy. Due to poor oral absorpti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff9d1fb7c9eaa89213e1d4a14957cbc3
https://doi.org/10.1200/jco.2019.37.15_suppl.tps1116

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Abstract GS6-01: Oral paclitaxel with encequidar: The first orally administered paclitaxel shown to be superior to IV paclitaxel on confirmed response and survival with less neuropathy: A phase III clinical study in metastatic breast cancer

Autor: J R Ramirez, M A Chivalan, Rubio D Kowalyszyn, Rosa Haydee Vassallo, J Goldfinch, Luis Fein, E Douglas Kramer, Gerardo Umanzor, Suyapa A. Bejarano, Rudolf Kwan, F J Barrios, Hui Wang, David L. Cutler, T Moore

Publikováno v: Cancer Research. 80:GS6-01

Intravenous paclitaxel (IV Pac) is an efficacious chemotherapeutic agent against multiple cancers including metastatic breast cancer (mBC). We hypothesized that the high peak concentration with IV Pac may be responsible for peripheral neuropathy. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::642781c9d59239439cceb9ca70eb64e1
https://doi.org/10.1158/1538-7445.sabcs19-gs6-01

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