Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Marco A Calzado"'
Autor:
Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Thomas Fischer, Susanne Walz, Christina Schülein‐Völk, Ursula Eilers, Carsten P Ade, Marco A Calzado, Amir Orian, Hans M Maric, Christian Münch, Mathias Rosenfeldt, Martin Eilers, Markus E Diefenbacher
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-25 (2020)
Abstract The transcription factor ∆Np63 is a master regulator of epithelial cell identity and essential for the survival of squamous cell carcinoma (SCC) of lung, head and neck, oesophagus, cervix and skin. Here, we report that the deubiquitylase U
Externí odkaz:
https://doaj.org/article/1898fb6a9b9447fe970065bbeeb04bce
Autor:
Martín Garrido-Rodriguez, Daniel Lopez-Lopez, Francisco M Ortuno, María Peña-Chilet, Eduardo Muñoz, Marco A Calzado, Joaquin Dopazo
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008748 (2021)
MIGNON is a workflow for the analysis of RNA-Seq experiments, which not only efficiently manages the estimation of gene expression levels from raw sequencing reads, but also calls genomic variants present in the transcripts analyzed. Moreover, this i
Externí odkaz:
https://doaj.org/article/65ddef7a579444e2b145e6b95460fc76
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3.
Autor:
Violeta Heras, Susana Sangiao-Alvarellos, Maria Manfredi-Lozano, María J Sanchez-Tapia, Francisco Ruiz-Pino, Juan Roa, Maribel Lara-Chica, Rosario Morrugares-Carmona, Nathalie Jouy, Ana P Abreu, Vincent Prevot, Denise Belsham, Maria J Vazquez, Marco A Calzado, Leonor Pinilla, Francisco Gaytan, Ana C Latronico, Ursula B Kaiser, Juan M Castellano, Manuel Tena-Sempere
Publikováno v:
PLoS Biology, Vol 17, Iss 11, p e3000532 (2019)
Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; yet, the molecular underpinnings of this key
Externí odkaz:
https://doaj.org/article/ef93c7a3add44a31bc7144e1863b1fe4
Autor:
Paula Moreno, Maribel Lara-Chica, Rafael Soler-Torronteras, Teresa Caro, Manuel Medina, Antonio Álvarez, Ángel Salvatierra, Eduardo Muñoz, Marco A Calzado
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143376 (2015)
OBJECTIVES:Lung cancer is the leading cause of cancer-related deaths worldwide. Overall 5-year survival has shown little improvement over the last decades. Seven in absentia homolog (SIAH) proteins are E3 ubiquitin ligases that mediate proteasomal pr
Externí odkaz:
https://doaj.org/article/29f34f7aa9f14f188a1883b7565e94fb
Autor:
Marc Boubnovski Martell, Kristofer Linton-Reid, Sumeet Hindocha, Mitchell Chen, Paula Moreno, Marina Álvarez‐Benito, Ángel Salvatierra, Richard Lee, Joram M. Posma, Marco A. Calzado, Eric O. Aboagye
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract The rich chemical information from tissue metabolomics provides a powerful means to elaborate tissue physiology or tumor characteristics at cellular and tumor microenvironment levels. However, the process of obtaining such information requir
Externí odkaz:
https://doaj.org/article/250c713102de44609ae31891985c0334
Autor:
Jaime López-Alcalá, Ana Gordon, Andrés Trávez, Carmen Tercero-Alcázar, Alejandro Correa-Sáez, María Jesús González-Rellán, Oriol A. Rangel-Zúñiga, Amaia Rodríguez, Antonio Membrives, Gema Frühbeck, Rubén Nogueiras, Marco A. Calzado, Rocío Guzmán-Ruiz, María M. Malagón
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-28 (2024)
Abstract Background Excessive lipid accumulation in the adipose tissue in obesity alters the endocrine and energy storage functions of adipocytes. Adipocyte lipid droplets represent key organelles coordinating lipid storage and mobilization in these
Externí odkaz:
https://doaj.org/article/67e13ce9f2ae45388dd0b4f7ac1984d8
Autor:
Ricardo Blázquez-Encinas, Víctor García-Vioque, Teresa Caro-Cuenca, María Trinidad Moreno-Montilla, Federica Mangili, Emilia Alors-Pérez, Sebastian Ventura, Aura D. Herrera-Martínez, Paula Moreno-Casado, Marco A. Calzado, Ángel Salvatierra, María A. Gálvez-Moreno, Lynnette Fernandez-Cuesta, Matthieu Foll, Raúl M. Luque, Nicolas Alcala, Sergio Pedraza-Arevalo, Alejandro Ibáñez-Costa, Justo P. Castaño
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly aggressive cancers. Carcinoids are the rarest LungNENs, display low to intermediate mali
Externí odkaz:
https://doaj.org/article/d52791785b0348c3acabc1dd11422717
Autor:
Verónica Alonso-Pérez, Vanessa Hernández, Marco A. Calzado, Alba Vicente-Blázquez, Consuelo Gajate, Rafael Soler-Torronteras, Kathleen DeCicco-Skinner, Angels Sierra, Faustino Mollinedo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116149- (2024)
Metastasis is the leading cause of cancer mortality. Metastatic cancer is notoriously difficult to treat, and it accounts for the majority of cancer-related deaths. The ether lipid edelfosine is the prototype of a family of synthetic antitumor compou
Externí odkaz:
https://doaj.org/article/2ecb67869ac54371a32f9c4d11807b5c
Autor:
Rafael Jiménez-Izquierdo, Rosario Morrugares, Lucía Suanes-Cobos, Alejandro Correa-Sáez, Martín Garrido-Rodríguez, Laura Cerero-Tejero, Omar M. Khan, Susana de la Luna, Rocío Sancho, Marco A. Calzado
Publikováno v:
Cell Death and Disease, Vol 14, Iss 3, Pp 1-14 (2023)
Abstract FBXW7 is a member of the F-box protein family, which functions as the substrate recognition component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several o
Externí odkaz:
https://doaj.org/article/9aee63207e8647eaa6ccbe6db4bdeada
Autor:
Laura Casares, Víctor García, Martín Garrido-Rodríguez, Estrella Millán, Juan A. Collado, Adela García-Martín, Jon Peñarando, Marco A. Calzado, Laureano de la Vega, Eduardo Muñoz
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that attracted a great attention for its therapeutic potential against different pathologies including skin diseases. However, although the efficacy in preclinical models and the clinical
Externí odkaz:
https://doaj.org/article/f5b8c7b912af43548f7298e90e944b3f