Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Marco, Scarselli"'
Autor:
Irene Fasciani, Francesco Petragnano, Ziming Wang, Ruairidh Edwards, Narasimha Telugu, Ilaria Pietrantoni, Ulrike Zabel, Henrik Zauber, Marlies Grieben, Maria E Terzenidou, Jacopo Di Gregorio, Cristina Pellegrini, Silvano Santini, Anna R Taddei, Bärbel Pohl, Stefano Aringhieri, Marco Carli, Gabriella Aloisi, Francesco Marampon, Eve Charlesworth, Alexandra Roman, Sebastian Diecke, Vincenzo Flati, Franco Giorgi, Fernanda Amicarelli, Andrew B Tobin, Marco Scarselli, Kostas Tokatlidis, Mario Rossi, Martin J Lohse, Paolo Annibale, Roberto Maggio
Publikováno v:
PLoS Biology, Vol 22, Iss 4, p e3002582 (2024)
Muscarinic acetylcholine receptors are prototypical G protein-coupled receptors (GPCRs), members of a large family of 7 transmembrane receptors mediating a wide variety of extracellular signals. We show here, in cultured cells and in a murine model,
Externí odkaz:
https://doaj.org/article/55337ca4f8c84555b649a08804c2bd5c
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 642 (2024)
Psychiatric disorders often require pharmacological interventions to alleviate symptoms and improve quality of life. However, achieving an optimal therapeutic outcome is challenging due to several factors, including variability in the individual resp
Externí odkaz:
https://doaj.org/article/dadc15651c3e40f79dffa9558b6ae426
Autor:
Roberto Maggio, Irene Fasciani, Francesco Petragnano, Maria Francesca Coppolino, Marco Scarselli, Mario Rossi
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1431 (2023)
Unstructured regions in functional proteins have gained attention in recent years due to advancements in informatics tools and biophysical methods. G protein-coupled receptors (GPCRs), a large family of cell surface receptors, contain unstructured re
Externí odkaz:
https://doaj.org/article/1514bf228c2d478d84181c88f8a7ca28
Autor:
Letizia Biso, Marco Carli, Shivakumar Kolachalam, Giorgio Monticelli, Pasquale Fabio Calabrò, Antonello di Paolo, Filippo Sean Giorgi, Guido Bocci, Marco Scarselli
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 945 (2023)
Despite receiving appropriate antiseizure medications (ASMs), a relevant percentage of neuropsychiatric patients do not benefit from this approach, and one reason is subtherapeutic ASMs plasma concentration (C(p)) due to improper drug adherence, inte
Externí odkaz:
https://doaj.org/article/938c3c880f484e77965fab7cb07d53fa
Autor:
Serena Barachini, Letizia Biso, Shivakumar Kolachalam, Iacopo Petrini, Roberto Maggio, Marco Scarselli, Biancamaria Longoni
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1426 (2023)
Pancreatic islet transplantation is a therapeutic option for achieving physiologic regulation of plasma glucose in Type 1 diabetic patients. At the same time, mesenchymal stem cells (MSCs) have demonstrated their potential in controlling graft reject
Externí odkaz:
https://doaj.org/article/d0ea75f46179483ea4f1eb94601b0ec8
Autor:
Irene Fasciani, Marco Carli, Francesco Petragnano, Francesco Colaianni, Gabriella Aloisi, Roberto Maggio, Marco Scarselli, Mario Rossi
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1343 (2022)
The architecture of eukaryotic cells is defined by extensive membrane-delimited compartments, which entails separate metabolic processes that would otherwise interfere with each other, leading to functional differences between cells. G protein-couple
Externí odkaz:
https://doaj.org/article/016d05c92c50493f8a50f1c0eab014a1
Autor:
David Moreno-Delgado, Mar Puigdellívol, Estefanía Moreno, Mar Rodríguez-Ruiz, Joaquín Botta, Paola Gasperini, Anna Chiarlone, Lesley A Howell, Marco Scarselli, Vicent Casadó, Antoni Cortés, Sergi Ferré, Manuel Guzmán, Carmen Lluís, Jordi Alberch, Enric I Canela, Silvia Ginés, Peter J McCormick
Publikováno v:
eLife, Vol 9 (2020)
Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of D1
Externí odkaz:
https://doaj.org/article/e29f5e9398d54a2882b616c452b949ae
Autor:
Marco Carli, Eleonora Risaliti, Mena Francomano, Shivakumar Kolachalam, Biancamaria Longoni, Guido Bocci, Roberto Maggio, Marco Scarselli
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 105 (2022)
Therapeutic drug monitoring (TDM) is an effective tool used to improve the pharmacological treatment in clinical practice, especially to detect subtherapeutic drug plasma concentration (Cp) in order to consider a change of dosage during treatment and
Externí odkaz:
https://doaj.org/article/20e92889feb84013b6d204dc596d6c84
Autor:
Roberto Maggio, Irene Fasciani, Marco Carli, Francesco Petragnano, Francesco Marampon, Mario Rossi, Marco Scarselli
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1828 (2021)
Information flow from a source to a receiver becomes informative when the recipient can process the signal into a meaningful form. Information exchange and interpretation is essential in biology and understanding how cells integrate signals from a va
Externí odkaz:
https://doaj.org/article/1112398a65554268822227484d9363dd
Autor:
Marco Carli, Francesca Vaglini, Eleonora Risaliti, Gianluca Citi, Matilde Masini, Shivakumar Kolachalam, Roberto Maggio, Giovanni Umberto Corsini, Michela Novelli, Vincenzo De Tata, Marco Scarselli
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 767 (2021)
Neurotoxins such as rotenone, 1-methyl-4-phenylpyridinium (MPP+) and 6-hydroxydopamine (6-OHDA) are well known for their high toxicity on dopaminergic neurons and are associated with Parkinson’s disease (PD) in murine models and humans. In addition
Externí odkaz:
https://doaj.org/article/3a4da212921c4aa0b2dc59b9cc633ceb