Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Marco, Pieroni"'
Autor:
Marialaura Pavone, Samanta Raboni, Marialaura Marchetti, Giannamaria Annunziato, Stefano Bettati, Bianca Papotti, Cinzia Marchi, Emanuele Carosati, Marco Pieroni, Barbara Campanini, Gabriele Costantino
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100443- (2022)
The development of the so-called antibiotic adjuvants as inhibitors of non-essential targets represents an innovative and attractive approach to counteract antimicrobial resistance (AMR). Most bacteria rely on the reductive sulfate assimilation pathw
Externí odkaz:
https://doaj.org/article/f9352bcf777d4f8cb3ed1438d8063420
Autor:
Joana Magalhães, Nina Franko, Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Anna Nikitjuka, Andrea Mozzarelli, Stefano Bettati, Anna Karawajczyk, Aigars Jirgensons, Barbara Campanini, Gabriele Costantino
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 31-43 (2019)
The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-threatening alarm. In order to develop enhancers of the antibacterial activity, we carried out a medicinal chemistry campaign aiming to develop inhibito
Externí odkaz:
https://doaj.org/article/a7f454e5900149429f6d3c19ae6529c0
Autor:
Giannamaria Annunziato, Costanza Spadini, Marialaura Marchetti, Nina Franko, Marialaura Pavone, Mattia Iannarelli, Agostino Bruno, Marco Pieroni, Stefano Bettati, Clotilde Silvia Cabassi, Barbara Campanini, Gabriele Costantino
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 766 (2022)
Antibacterial adjuvants are of great significance, since they allow one to downscale the therapeutic dose of conventional antibiotics and reduce the insurgence of antibacterial resistance. Herein, we report that O-acetylserine sulfhydrylase (OASS) in
Externí odkaz:
https://doaj.org/article/a4c0d428c9844ac3b8d2f6512eb7e7a4
Autor:
Joana Magalhães, Nina Franko, Giannamaria Annunziato, Martin Welch, Stephen K. Dolan, Agostino Bruno, Andrea Mozzarelli, Stefano Armao, Aigars Jirgensons, Marco Pieroni, Gabriele Costantino, Barbara Campanini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1444-1452 (2018)
Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in antibiotic resistance have already been associated with mutations on the genes that codify cysteine
Externí odkaz:
https://doaj.org/article/30e250b250a64c3580f2300940788456
Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases
Autor:
Giannamaria Annunziato, Laura Giovati, Andrea Angeli, Marialaura Pavone, Sonia Del Prete, Marco Pieroni, Clemente Capasso, Agostino Bruno, Stefania Conti, Walter Magliani, Claudiu T. Supuran, Gabriele Costantino
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1537-1544 (2018)
Infections caused by pathogens resistant to the available antimicrobial treatments represent nowadays a threat to global public health. Recently, it has been demonstrated that carbonic anhydrases (CAs) are essential for the growth of many pathogens a
Externí odkaz:
https://doaj.org/article/866c6fb23b9740298ef45e53988bde41
Autor:
Joana Magalhães, Nina Franko, Samanta Raboni, Giannamaria Annunziato, Päivi Tammela, Agostino Bruno, Stefano Bettati, Stefano Armao, Costanza Spadini, Clotilde Silvia Cabassi, Andrea Mozzarelli, Marco Pieroni, Barbara Campanini, Gabriele Costantino
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 174 (2021)
Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibacterial treatment and establish a long-lasting infection. In turn, this might lead to the onset of antimicrobial resistance that currently represents o
Externí odkaz:
https://doaj.org/article/f1d7405d6d5a4d12aad19e9550530af9
Autor:
Mirco Dindo, Egidia Costanzi, Marco Pieroni, Claudio Costantini, Giannamaria Annunziato, Agostino Bruno, Nancy P. Keller, Luigina Romani, Teresa Zelante, Barbara Cellini
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
The rise in the frequency of nosocomial infections is becoming a major problem for public health, in particular in immunocompromised patients. Aspergillus fumigatus is an opportunistic fungus normally present in the environment directly responsible f
Externí odkaz:
https://doaj.org/article/ccf12ae7da1948afab49db974d7bf608
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
The emergence of multi- and extensively drug resistant tuberculosis worldwide poses a great threat to human health and highlight the need to discover and develop new, effective and inexpensive antituberculosis agents. High-throughput screening assays
Externí odkaz:
https://doaj.org/article/0e0adc9d8fa54e859f1021fbe8614994
Autor:
Miriam Girardini, Francesca Ferlenghi, Giannamaria Annunziato, Giulia Degiacomi, Bianca Papotti, Cinzia Marchi, José Camilla Sammartino, Sari S. Rasheed, Anna Contini, Maria Rosalia Pasca, Federica Vacondio, Joanna C. Evans, Thomas Dick, Rolf Müller, Gabriele Costantino, Marco Pieroni
Publikováno v:
European journal of medicinal chemistry. 245(Pt 2)
Tuberculosis is one of the deadliest infectious diseases in the world, and the increased number of multidrug-resistant and extensively drug-resistant strains is a reason for concern. We have previously reported a series of substituted 5-(2-aminothiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d556586d0dc98466a9fd63b1793cbe
https://pubmed.ncbi.nlm.nih.gov/36399878
https://pubmed.ncbi.nlm.nih.gov/36399878
Autor:
Silvia Grottelli, Giannamaria Annunziato, Gioena Pampalone, Marco Pieroni, Mirco Dindo, Francesca Ferlenghi, Gabriele Costantino, Barbara Cellini
Publikováno v:
Journal of medicinal chemistry. 65(14)
Primary hyperoxaluria type I (PH1) is a rare kidney disease due to the deficit of alanine:glyoxylate aminotransferase (AGT), a pyridoxal-5'-phosphate-dependent enzyme responsible for liver glyoxylate detoxification, which in turn prevents oxalate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156b0c82bb4dd596a8be262a60c1354b
https://pubmed.ncbi.nlm.nih.gov/35830169
https://pubmed.ncbi.nlm.nih.gov/35830169