Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Marco, Osterwalder"'
A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival
Autor:
Samuel Abassah-Oppong, Matteo Zoia, Brandon J. Mannion, Raquel Rouco, Virginie Tissières, Cailyn H. Spurrell, Virginia Roland, Fabrice Darbellay, Anja Itum, Julie Gamart, Tabitha A. Festa-Daroux, Carly S. Sullivan, Michael Kosicki, Eddie Rodríguez-Carballo, Yoko Fukuda-Yuzawa, Riana D. Hunter, Catherine S. Novak, Ingrid Plajzer-Frick, Stella Tran, Jennifer A. Akiyama, Diane E. Dickel, Javier Lopez-Rios, Iros Barozzi, Guillaume Andrey, Axel Visel, Len A. Pennacchio, John Cobb, Marco Osterwalder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Approximately a quarter of the human genome consists of gene deserts, large regions devoid of genes often located adjacent to developmental genes and thought to contribute to their regulation. However, defining the regulatory functions embed
Externí odkaz:
https://doaj.org/article/ea97ba56f1764b518e534e1063bf2e68
Autor:
Sudha Sunil Rajderkar, Kitt Paraiso, Maria Luisa Amaral, Michael Kosicki, Laura E. Cook, Fabrice Darbellay, Cailyn H. Spurrell, Marco Osterwalder, Yiwen Zhu, Han Wu, Sarah Yasmeen Afzal, Matthew J. Blow, Guy Kelman, Iros Barozzi, Yoko Fukuda-Yuzawa, Jennifer A. Akiyama, Veena Afzal, Stella Tran, Ingrid Plajzer-Frick, Catherine S. Novak, Momoe Kato, Riana D. Hunter, Kianna von Maydell, Allen Wang, Lin Lin, Sebastian Preissl, Steven Lisgo, Bing Ren, Diane E. Dickel, Len A. Pennacchio, Axel Visel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial d
Externí odkaz:
https://doaj.org/article/ad066eccb027472d812a541544ff79a2
Autor:
Cassie L. Kemmler, Jana Smolikova, Hannah R. Moran, Brandon J. Mannion, Dunja Knapp, Fabian Lim, Anna Czarkwiani, Viviana Hermosilla Aguayo, Vincent Rapp, Olivia E. Fitch, Seraina Bötschi, Licia Selleri, Emma Farley, Ingo Braasch, Maximina Yun, Axel Visel, Marco Osterwalder, Christian Mosimann, Zbynek Kozmik, Alexa Burger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The cell type-specific expression of key transcription factors is central to development and disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression
Externí odkaz:
https://doaj.org/article/8918433ad9dc464ebd1fe886936070f5
Autor:
Marta Losa, Iros Barozzi, Marco Osterwalder, Viviana Hermosilla-Aguayo, Angela Morabito, Brandon H. Chacón, Peyman Zarrineh, Ausra Girdziusaite, Jean Denis Benazet, Jianjian Zhu, Susan Mackem, Terence D. Capellini, Diane Dickel, Nicoletta Bobola, Aimée Zuniga, Axel Visel, Rolf Zeller, Licia Selleri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract A lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform tissue-specific functions. Here, using the murine hindlimb as a model, we investigate the
Externí odkaz:
https://doaj.org/article/7c9a9b83afdc4ea8afaf6d100fd069b1
Autor:
Shiri Kult, Tsviya Olender, Marco Osterwalder, Svetalana Markman, Dena Leshkowitz, Sharon Krief, Ronnie Blecher-Gonen, Shani Ben-Moshe, Lydia Farack, Hadas Keren-Shaul, Tomer-Meir Salame, Terence D Capellini, Shalev Itzkovitz, Ido Amit, Axel Visel, Elazar Zelzer
Publikováno v:
eLife, Vol 10 (2021)
The mechanical challenge of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tissue. Here, we show that murine tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte
Externí odkaz:
https://doaj.org/article/d634c0b6552b4485bd6640c59f2a7db5
Autor:
Frédéric Laurent, Ausra Girdziusaite, Julie Gamart, Iros Barozzi, Marco Osterwalder, Jennifer A. Akiyama, Joy Lincoln, Javier Lopez-Rios, Axel Visel, Aimée Zuniga, Rolf Zeller
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1602-1613 (2017)
The HAND2 transcriptional regulator controls cardiac development, and we uncover additional essential functions in the endothelial to mesenchymal transition (EMT) underlying cardiac cushion development in the atrioventricular canal (AVC). In Hand2-de
Externí odkaz:
https://doaj.org/article/f88dd9f519ce4a2cbd3c44cff84ccf43
Autor:
Cassie L. Kemmler, Jana Smolikova, Hannah R. Moran, Brandon J. Mannion, Dunja Knapp, Fabian Lim, Anna Czarkwiani, Viviana Hermosilla Aguayo, Vincent Rapp, Olivia E. Fitch, Seraina Bötschi, Licia Selleri, Emma Farley, Ingo Braasch, Maximina Yun, Axel Visel, Marco Osterwalder, Christian Mosimann, Zbynek Kozmik, Alexa Burger
Publikováno v:
bioRxiv
The cell type-specific expression of key transcription factors is central to development. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression is controlled in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a48f7f01710dc2f9007ba15f249db7
https://europepmc.org/articles/PMC10153258/
https://europepmc.org/articles/PMC10153258/
Autor:
Diane E. Dickel, Iros Barozzi, Yiwen Zhu, Yoko Fukuda-Yuzawa, Marco Osterwalder, Brandon J. Mannion, Dalit May, Cailyn H. Spurrell, Ingrid Plajzer-Frick, Catherine S. Pickle, Elizabeth Lee, Tyler H. Garvin, Momoe Kato, Jennifer A. Akiyama, Veena Afzal, Ah Young Lee, David U. Gorkin, Bing Ren, Edward M. Rubin, Axel Visel, Len A. Pennacchio
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Identification of non-coding variants has outstripped our ability to annotate and interpret them. Dickel et al. present a compendium of over 80,000 putative human heart enhancers and demonstrate that two conserved enhancers are required for proper ca
Externí odkaz:
https://doaj.org/article/b001d43a207246388e738ba39f9b2876
Autor:
Rajani M. George, Beth A. Firulli, Ram Podicheti, Douglas B. Rusch, Brandon J. Mannion, Len A. Pennacchio, Marco Osterwalder, Anthony B. Firulli
Publikováno v:
Development. 150
The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2 endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with accompanying intraventricular septum defects, hypo-trabeculated ventricles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe585e342bf07de420b1f4a1b8f059cb
https://doi.org/10.1242/dev.201341
https://doi.org/10.1242/dev.201341
Autor:
Magdalena Schindler, Marco Osterwalder, Izabela Harabula, Lars Wittler, Athanasia C. Tzika, Dina Dechmann, Martin Vingron, Axel Visel, Stefan Haas, Francisca M. Real
Publikováno v:
bioRxiv
Changes in gene expression represent an important source for phenotypical innovation. Yet, how such changes emerge and impact the evolution of traits remains elusive. Here, we explore the molecular mechanisms associated with the development of mascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822acd92dfc83410e981b2091ef27da6
https://doi.org/10.1101/2022.10.28.514220
https://doi.org/10.1101/2022.10.28.514220