Výsledky vyhledávání - "Marco, Manoni"

Effects of a semi-synthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/ reperfusion injury

Autor: Liana Salsini, Emanuela Masini, Marco Manoni, Jacopo Chini, Sara Castiglia, Massimo Collino, Roberto Fantozzi

Publikováno v: Thrombosis and Haemostasis. 102:837-845

SummaryHeparin and low molecular weight heparins may reduce brain damage evoked by ischaemia/reperfusion (I/R) injury, although their use is hampered by the risk of haemorrhage. Chemical and enzymatic modifications of K5 polysaccharide have shown the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314d740450903c1a2894545046fe4d59
https://doi.org/10.1160/th09-01-0012

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Relative Neutralization of the Biological Actions of Sulfaminoheparosans (K5 Derivatives) and Heparins by Protamine Sulfate

Autor: Jawed Fareed, Umberto Cornelli, Marco Manoni, Debra Hoppensteadt, Jyothi Maddineni

Publikováno v: Clinical and Applied Thrombosis/Hemostasis. 13:52-64

Biosynthetic, semisynthetic, and synthetic analogues of heparins are currently developed as substitute antithrombotic agents for heparin. Sulfaminoheparosan (SAH) represents a bacterial polysaccharide (K5)-derived antithrombotic polymer from which ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e61934f65f53e9bc6e9c1623187afee
https://doi.org/10.1177/1076029606296403

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Modulatory Effects of Escherichia coli Capsular–Derived Sulfaminoheparosans and Heparins on Tissue Factor–Mediated Activation of Platelets: Flow Cytometric Analysis

Autor: Debra Hoppensteadt, Marco Manoni, Umberto Cornelli, Jyothi Maddineni, Walter Jeske, Francis Baltasar, Jawed Fareed

Publikováno v: Clinical and Applied Thrombosis/Hemostasis. 12:311-317

Sulfaminoheparosans (alternatively known as bioheparins) represent sulfated derivatives obtained from the K5 capsular polysaccharide of Escherichia coli. Previous studies have shown that these agents are structurally comparable to heparins and capabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4eafbb71fe8d421ada3b29aa46ffd66
https://doi.org/10.1177/1076029606291426

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The non-anticoagulant heparin-like K5 polysaccharide derivative K5-N,OSepi attenuates myocardial ischaemia/reperfusion injury

Autor: Massimo, Collino, Collino, Massimo, Alessandro, Pini, Pini, Alessandro, Rosanna, Mastroianni, Mastroianni, Rosanna, Elisa, Benetti, Benetti, Elisa, Cecilia, Lanzi, Lanzi, Cecilia, Daniele, Bani, Bani, Daniele, Chini, Jacopo, Marco, Manoni, Manoni, Marco, Roberto, Fantozzi, Fantozzi, Roberto, Emanuela, Masini, Masini, Emanuela

Publikováno v: Journal of Cellular and Molecular Medicine

Heparin and low molecular weight heparins have been demonstrated to reduce myocardial ischaemia/reperfusion (I/R) injury, although their use is hampered by the risk of haemorrhagic and thrombotic complications. Chemical and enzymatic modifications of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55dfccea6b46f6e198ae26f31c7e61f8
http://hdl.handle.net/2318/117394

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Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy

Autor: Matteo Ceccarelli, Daniele Bani, Lorenzo Cinci, Silvia Nistri, Caterina Uliva, Elena Ragazzo, Alfredo Vannacci, Marco Manoni, Anna Maria Gori, Rosanna Abbate, Gian Franco Gensini, Emanuela Masini

Low molecular weight heparin derivatives are characterized by low anti-coagulant activity and marked anti-inflammatory effects that allow for these molecules to be viewed as a new class of non-steroidal anti-inflammatory drugs (NSAIDs). We show here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cea6628bd257c6f892f0ae204609b2
http://hdl.handle.net/2158/387742

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Cytokine gene expression and production by human LPS-stimulated mononuclear cells are inhibited by sulfated heparin-like semi-synthetic derivatives

Autor: Laura Lucarini, Monica Attanasio, L. Rossi, Jacopo Chini, Sandro Miletti, Marco Manoni, Anna Maria Gori, Rosanna Abbate, Alessandra Gazzini, Gian Franco Gensini

Publikováno v: Journal of thrombosis and haemostasis : JTH. 2(9)

The K5 polysaccharide obtained from Escherichia coli strain 010:K5:H4 is a polymer of the disaccharidic unit formed by D-glucuronic acid and N-acetylglucosamine. This structure is akin to N-acetylheparosan, the precursory polymer of heparin and of he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1605604558f994bf261c8e2e92a10d86
https://pubmed.ncbi.nlm.nih.gov/15333044

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Molecular and pharmacologic profile of tinzaparin and a comparable low-molecular-weight bacterial sulfaminoheparosan

Autor: Umberto Cornelli, Debra Hoppensteadt, Jyothi Maddineni, Muzaffer Demir, Marco Manoni, Jawed Fareed, Qing Ma

Publikováno v: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 10(1)

Low-molecular-weight heparins (LMWH) represent depolymerized porcine mucosal heparin derivatives, which are commonly used for the management of thrombotic disorders. Because of their widespread usage, the supplies of the raw material namely unfractio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84b0c672d4aaa13e2114df347aa12b0
https://pubmed.ncbi.nlm.nih.gov/14979402

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Human recombinant antibody fragments specific for a rye-grass pollen allergen: characterization and potential applications

Autor: Claudia de Lalla, Elena Tamborini, Paolo Arosio, Marco Manoni, Alessandro Sidoli, Eleonora Tresoldi, Renato Longhi, Antonio G. Siccardi

One of the major allergens from the pollen of perennial rye grass (Lolium perenne), Lol pII, was used to isolate specific antibody fragments from a random combinatorial library displaying a large repertoire of human Fab on filamentous phages. After f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993f9f13a467c9cf114b52a4c49c7a1d
http://hdl.handle.net/11379/47202

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