Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Marco, Macchia"'
Autor:
Miriana Di Stefano, Salvatore Galati, Lisa Piazza, Francesca Gado, Carlotta Granchi, Marco Macchia, Antonio Giordano, Tiziano Tuccinardi, Giulio Poli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
We present a new computational approach, named Watermelon, designed for the development of pharmacophore models based on receptor structures. The methodology involves the sampling of potential hotspots for ligand interactions within a protein target
Externí odkaz:
https://doaj.org/article/3961fed658e1472d8c4b064e407e4d66
Publikováno v:
Nutrients, Vol 16, Iss 10, p 1474 (2024)
Extra virgin olive oil (EVOO) is a symbol of the Mediterranean diet, constituting its primary source of fat. The beneficial effect of EVOO is strictly related to the presence of fatty acids and polyphenols, bioactive compounds endowed with nutraceuti
Externí odkaz:
https://doaj.org/article/7502a7429ec54fbbab1a2c41c38fc77d
Autor:
Giulio Poli, Gian Carlo Demontis, Andrea Sodi, Alessandro Saba, Stanislao Rizzo, Marco Macchia, Tiziano Tuccinardi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
hRPE65 is a fundamental enzyme of the retinoid visual cycle, and many missense mutations affecting its expression or function are associated with a wide range of diseases. Many hRPE65 missense mutations lack a clear pathogenicity classification or ar
Externí odkaz:
https://doaj.org/article/7c89f3b7f8fb4854b84bd0e0b60daf9f
Autor:
Giulio Poli, Ivana Barravecchia, Gian Carlo Demontis, Andrea Sodi, Alessandro Saba, Stanislao Rizzo, Marco Macchia, Tiziano Tuccinardi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1765-1772 (2022)
The human retinal pigment epithelium-specific 65-kDa protein (hRPE65) plays a crucial role within the retinoid visual cycle and several mutations affecting either its expression level or its enzymatic function are associated with inherited retinal di
Externí odkaz:
https://doaj.org/article/32ce20e5e4674bca8efb26b1a3d728b6
Autor:
Salvatore Galati, Miriana Di Stefano, Simone Bertini, Carlotta Granchi, Antonio Giordano, Francesca Gado, Marco Macchia, Tiziano Tuccinardi, Giulio Poli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17233 (2023)
Glycogen synthase kinase-3 beta (GSK3β) is a serine/threonine kinase that plays key roles in glycogen metabolism, Wnt/β-catenin signaling cascade, synaptic modulation, and multiple autophagy-related signaling pathways. GSK3β is an attractive targe
Externí odkaz:
https://doaj.org/article/cf65f0311c554eb48d63112e232e2afa
Publikováno v:
Nutrients, Vol 15, Iss 23, p 4966 (2023)
Nowadays, it has been amply demonstrated how an appropriate diet and lifestyle are essential for preserving wellbeing and preventing illnesses [...]
Externí odkaz:
https://doaj.org/article/0469edb0a9f14b32a1d636bb3af53736
Autor:
Daniela Gabbia, Sara Carpi, Samantha Sarcognato, Ilaria Zanotto, Katia Sayaf, Martina Colognesi, Beatrice Polini, Maria Digiacomo, Marco Macchia, Paola Nieri, Maria Carrara, Nora Cazzagon, Francesco Paolo Russo, Maria Guido, Sara De Martin
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 157, Iss , Pp 114014- (2023)
Liver fibrosis is the result of a chronic pathological condition caused by the activation of hepatic stellate cells (HSCs), which induces the excessive deposition of extracellular matrix. Fibrogenesis is sustained by an exaggerated production of reac
Externí odkaz:
https://doaj.org/article/4a24bdd493fa4d008b242f3c996f010c
Autor:
Giulio Poli, Miriana Di Stefano, Joan Arias Estevez, Filippo Minutolo, Carlotta Granchi, Antonio Giordano, Salvatore Parisi, Matteo Mauceri, Vincenzo Canzonieri, Marco Macchia, Isabella Caligiuri, Tiziano Tuccinardi, Flavio Rizzolio
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 145-150 (2022)
PIN1 is considered as a therapeutic target for a wide variety of tumours. However, most of known inhibitors are devoid of cellular activity despite their good enzyme inhibitory profile. Hence, the lack of effective compounds for the clinic makes the
Externí odkaz:
https://doaj.org/article/cf62bc6b195e4bc6b05154bb0957ad8b
Autor:
Doretta Cuffaro, Andrea Bertolini, Simone Bertini, Claudio Ricci, Maria Grazia Cascone, Serena Danti, Alessandro Saba, Marco Macchia, Maria Digiacomo
Publikováno v:
Nutrients, Vol 15, Iss 17, p 3746 (2023)
Background: Agrifood waste products are often considered rich sources of bioactive compounds that can be conveniently recovered. Due to these peculiar characteristics, the study of these waste products is attracting great interest in nutraceutical re
Externí odkaz:
https://doaj.org/article/d397dd61af1142558fff6dc207dd360a
Autor:
Doretta Cuffaro, Diana Pinto, Ana Margarida Silva, Andrea Bertolini, Simone Bertini, Alessandro Saba, Marco Macchia, Francisca Rodrigues, Maria Digiacomo
Publikováno v:
Molecules, Vol 28, Iss 13, p 5150 (2023)
(1) Background: In recent years, numerous studies have highlighted the beneficial effects of extra virgin olive oil (EVOO) as an active ingredient against chronic diseases. The properties of EVOO are due to its peculiar composition, mainly to its ric
Externí odkaz:
https://doaj.org/article/2e0829129a1f416db888bb48995b2698