Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Marco, Giovannini"'
Autor:
Shilpa Prabhakar, Roberta L. Beauchamp, Pike See Cheah, Akiko Yoshinaga, Edwina Abou Haidar, Sevda Lule, Gayathri Mani, Katia Maalouf, Anat Stemmer-Rachamimov, David H. Jung, D. Bradley Welling, Marco Giovannini, Scott R. Plotkin, Casey A. Maguire, Vijaya Ramesh, Xandra O. Breakefield
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101262- (2024)
Externí odkaz:
https://doaj.org/article/3e5ab6a0da2740adbac015462c8c83b4
Autor:
Brian Na, Blake Haist, Shilp R. Shah, Graeme Sabiston, Steven J. Jonas, Jeremie Vitte, Richard E. Wirz, Marco Giovannini
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1986 (2024)
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder resulting from mutations in the NF1 gene. Patients harboring these mutations are predisposed to a spectrum of peripheral nerve sheath tumors (PNSTs) originating from Schwann cells, of w
Externí odkaz:
https://doaj.org/article/3f901916f71d4f779f1172116037a70f
Autor:
Christine Chiasson-MacKenzie, Jeremie Vitte, Ching-Hui Liu, Emily A. Wright, Elizabeth A. Flynn, Shannon L. Stott, Marco Giovannini, Andrea I. McClatchey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Schwannomas are mainly caused by NF2 tumour suppressor inactivation, but they display intratumoural heterogeneity. Here the authors show that this heterogeneity is caused by the loss of polarity and acquisition of different programmes of ErbB ligand
Externí odkaz:
https://doaj.org/article/910ca0cc6a5e4813874a61e9dbcdad7c
Autor:
Pasquale Niscola, Valentina Gianfelici, Marco Giovannini, Daniela Piccioni, Carla Mazzone, Paolo de Fabritiis
Publikováno v:
Cancers, Vol 16, Iss 8, p 1563 (2024)
Myelodysplastic syndromes/neoplasms (MDSs) encompass a range of hematopoietic malignancies, commonly affecting elderly individuals. Molecular alterations in the hematopoietic stem cell compartment drive disease pathogenesis. Recent advancements in ge
Externí odkaz:
https://doaj.org/article/7d0dc25624724c0f9c5344ae790ece71
Autor:
Pasquale Niscola, Carla Mazzone, Nicolina Rita Ardu, Laura Cesini, Marco Giovannini, Stefano Fratoni, Paolo de Fabritiis
Publikováno v:
HemaSphere, Vol 7, p e4005998 (2023)
Externí odkaz:
https://doaj.org/article/2b2fe38144bd49a1b4f80e3ab6bea7f1
Autor:
Shilpa Prabhakar, Roberta L. Beauchamp, Pike See Cheah, Akiko Yoshinaga, Edwina Abou Haidar, Sevda Lule, Gayathri Mani, Katia Maalouf, Anat Stemmer-Rachamimov, David H. Jung, D. Bradley Welling, Marco Giovannini, Scott R. Plotkin, Casey A. Maguire, Vijaya Ramesh, Xandra O. Breakefield
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 169-180 (2022)
Loss of function of the neurofibromatosis type 2 (NF2) tumor suppressor gene leads to the formation of schwannomas, meningiomas, and ependymomas, comprising ∼50% of all sporadic cases of primary nervous system tumors. NF2 syndrome is an autosomal d
Externí odkaz:
https://doaj.org/article/7beaec1f53b24b3a8b2e347e32d796ca
Autor:
Scott R. Plotkin, Ludwine Messiaen, Eric Legius, Patrice Pancza, Robert A. Avery, Jaishri O. Blakeley, Dusica Babovic-Vuksanovic, Rosalie Ferner, Michael J. Fisher, Jan M. Friedman, Marco Giovannini, David H. Gutmann, Clemens Oliver Hanemann, Michel Kalamarides, Hildegard Kehrer-Sawatzki, Bruce R. Korf, Victor-Felix Mautner, Mia MacCollin, Laura Papi, Katherine A. Rauen, Vincent Riccardi, Elizabeth Schorry, Miriam J. Smith, Anat Stemmer-Rachamimov, David A. Stevenson, Nicole J. Ullrich, David Viskochil, Katharina Wimmer, Kaleb Yohay, Susan M. Huson, Pierre Wolkenstein, D. Gareth Evans, Monique Anten, Arthur Aylsworth, Diana Baralle, Sebastien Barbarot, Fred Barker, Shay Ben-Shachar, Amanda Bergner, Didier Bessis, Ignacio Blanco, Catherine Cassiman, Patricia Ciavarelli, Maurizio Clementi, Thierry Frébourg, Alicia Gomes, Dorothy Halliday, Chris Hammond Helen Hanson Arvid Heiberg, Pascal Joly, Justin T. Jordan, Matthias Karajannis, Daniela Kroshinsky, Margarita Larralde, Conxi Lázaro, Lu Le, Michael Link, Robert Listernick, Conor Mallucci, Vanessa L. Merker, Christopher Moertel, Amy Mueller, Joanne Ngeow, Rianne Oostenbrink, Roger Packer, Allyson Parry, Juha Peltonen, Dominique Pichard, Bruce Poppe, Nilton Rezende, Luiz Oswaldo Rodrigues, Tena Rosser, Martino Ruggieri, Eduard Serra, Verena Steinke-Lange, Stavros Michael Stivaros, Amy Taylor, Jaan Toelen, James Tonsgard, Eva Trevisson, Meena Upadhyaya, Ali Varan, Meredith Wilson, Hao Wu, Gelareh Zadeh
Publikováno v:
Genetics in Medicine, 24(9), 1967-1977. Lippincott Williams & Wilkins
PURPOSE: Neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are genetically distinct tumor predisposition syndromes with overlapping phenotypes. We sought to update the diagnostic criteria for NF2 and SWN by incorporating recent advances in gen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at la
Externí odkaz:
https://doaj.org/article/1faf2971b5a4423bb8a856e7f90310eb
Autor:
Marco Giovannini, Allan E. Rubenstein, Stanley F. Nelson, Zahara M. Jaffer, Jeremie Vitte, Cory H. White, Ruihong Chen, Michiko Niwa-Kawakita, Jan Manent, Walter J. Jessen, Fabrice Chareyre, Ascia Eskin, Karo Tanaka
Supplementary Materials - PDF files 113K, Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1babe054ff3e0ba7cfc7046cf73aafb1
https://doi.org/10.1158/1078-0432.22450142.v1
https://doi.org/10.1158/1078-0432.22450142.v1
Autor:
Marco Giovannini, Allan E. Rubenstein, Stanley F. Nelson, Zahara M. Jaffer, Jeremie Vitte, Cory H. White, Ruihong Chen, Michiko Niwa-Kawakita, Jan Manent, Walter J. Jessen, Fabrice Chareyre, Ascia Eskin, Karo Tanaka
Purpose: The growth and survival of neurofibromatosis type 2 (NF2)–deficient cells are enhanced by the activation of multiple signaling pathways including ErbBs/IGF-1R/Met, PI3K/Akt, and Ras/Raf/Mek/Erk1/2. The chaperone protein HSP90 is essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992944eb4a6ab43c00b7bc780e26e4a6
https://doi.org/10.1158/1078-0432.c.6521864.v1
https://doi.org/10.1158/1078-0432.c.6521864.v1