Vasorin-deficient mice display disturbed vitamin D and mineral homeostasis in combination with a low bone mass phenotype

Autor: Marco Eijken, A. Michaela Krautzberger, Manuela Scholze-Wittler, Bianca Boers-Sijmons, Marijke Koedam, Barbara Kosiol, Heinrich Schrewe, Johannes P. van Leeuwen, Bram C. van der Eerden

Publikováno v: Bone Reports, Vol 22, Iss , Pp 101792- (2024)

Vasorin (Vasn) is a pleiotropic molecule involved in various physiological and pathological conditions, including cancer. Vasn has also been detected in bone cells of developing skeletal tissues but no function for Vasn in bone metabolism has been im

Externí odkaz: https://doaj.org/article/fb30148d48904876972ed4fe2a7c03eb

Reconstitution and post-thaw storage of cryopreserved human mesenchymal stromal cells: Pitfalls and optimizations for clinically compatible formulants

Autor: Rasmus Roost Aabling, Toke Alstrup, Emma Mader Kjær, Kristine Juul Poulsen, Jonas Oute Pedersen, Anne Louise Revenfeld, Bjarne Kuno Møller, Marco Eijken

Publikováno v: Regenerative Therapy, Vol 23, Iss , Pp 67-75 (2023)

Introduction: The regenerative and immunomodulatory properties of multipotent mesenchymal stromal cells (MSCs) make them an intriguing asset for therapeutic applications. An off-the-shelf approach, using pre-expanded cryopreserved allogenic MSCs, byp

Externí odkaz: https://doaj.org/article/9e1c4a4caa0640baaf79c55ca8eb7c85

H2S-Enriched Flush out Does Not Increase Donor Organ Quality in a Porcine Kidney Perfusion Model

Autor: Hanno Maassen, Leonie H. Venema, Marc G. Weiss, Tobias M. Huijink, H. Sijbrand Hofker, Anna K. Keller, Tom E. Mollnes, Marco Eijken, Søren E. Pischke, Bente Jespersen, Harry van Goor, Henri G. D. Leuvenink

Publikováno v: Antioxidants, Vol 12, Iss 3, p 749 (2023)

Kidney extraction time has a detrimental effect on post-transplantation outcome. This study aims to improve the flush-out and potentially decrease ischemic injury by the addition of hydrogen sulphide (H2S) to the flush medium. Porcine kidneys (n = 22

Externí odkaz: https://doaj.org/article/883abdf9886d4ee194a43847362ce2fc

A Pilot Study of Postoperative Animal Welfare as a Guidance Tool in the Development of a Kidney Autotransplantation Model With Extended Warm Ischemia

Autor: Stine Lohmann, MD, Marco Eijken, PhD, Ulla Møldrup, MD, Bjarne K. Møller, MD, James Hunter, MD, BSc(hons), MBChB, Cyril Moers, MD, PhD, Rutger J. Ploeg, MD, PhD, Carla C. Baan, PhD, Bente Jespersen, MD, PhD, Anna Krarup Keller, MD, PhD

Publikováno v: Transplantation Direct, Vol 5, Iss 11, p e495 (2019)

Background. This pilot study aimed to maintain acceptable animal welfare in the development of a porcine autotransplantation model with severe and incremental renal ischemic injury, a model for usage in future intervention studies. Secondary aims wer

Externí odkaz: https://doaj.org/article/1817d096667f4457b556ad159d4b830c

Ex-vivo mRNA therapy to predict kidney vitality during transplantation

Autor: Ping Song, Jesper Staulund, Haiyun Qi, Lars Thrane, Michael Pedersen, Marco Eijken, Bente Jespersen, Jorgen Kjems

Publikováno v: Song, P, Staulund, J, Qi, H, Thrane, L, Pedersen, M, Eijken, M, Jespersen, B & Kjems, J 2022, ' Ex-vivo mRNA therapy to predict kidney vitality during transplantation ', Danish RNA Society's 7th Annual Meeting, Aarhus, Denmark, 11/10/2022-11/10/2022 .
Aarhus University

High-risk kidneys have been used for transplantation due to the big gap between supply and demand for kidney transplantation, which sometimes exhibit unexpected prognosis. Presently, it is still a great challenge to predict the function and metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cc0ecbdc145a5ea7baecc093679e4c59
https://pure.au.dk/portal/da/publications/exvivo-mrna-therapy-to-predict-kidney-vitality-during-transplantation(af321761-0d1d-4a36-a314-cc5ebda36388).html