Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Marco, Demaria"'
Autor:
Sophia Magkouta, Dimitris Veroutis, Athanasios Pousias, Angelos Papaspyropoulos, Kety Giannetti, Natassa Pippa, Nikolaos Lougiakis, Konstantinos Kambas, Nefeli Lagopati, Aikaterini Polyzou, Maria Georgiou, Maria Chountoulesi, Stergios Pispas, Spyros Foutadakis, Efthymios Kyrodimos, Nicole Pouli, Panagiotis Marakos, Athanassios Kotsinas, Panayotis Verginis, Dimitrios Valakos, Giannis Vatsellas, Russell Petty, Dimitris Thanos, Marco Demaria, Konstantinos Evangelou, Raffaella Di Micco, Vassilis G. Gorgoulis
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102929- (2024)
Summary: Identification and isolation of senescent cells is challenging, rendering their detailed analysis an unmet need. We describe a precise one-step protocol to fluorescently label senescent cells, for flow cytometry and fluorescence microscopy,
Externí odkaz:
https://doaj.org/article/ed81a3ca446743eca624a9664aad2cf8
Autor:
Jaskaren Kohli, Chen Ge, Eleni Fitsiou, Miriam Doepner, Simone M. Brandenburg, William J. Faller, Todd W. Ridky, Marco Demaria
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Cutaneous hyperpigmented lesions, including nevi, are populated by senescent melanocytes. Here the authors provide evidence for a novel strategy based on combining inhibition of the BCL-2 and MCL1 anti-apoptotic pathways that selectively eliminates s
Externí odkaz:
https://doaj.org/article/8202b04d72ce4f228b04c8c3764d037c
Publikováno v:
Biomedical Journal, Vol 46, Iss 3, Pp 100585- (2023)
Evidence supports the notion that metabolic pathways are major regulators of organismal aging, and that metabolic perturbations can extend health- and lifespan. For this reason, dietary interventions and compounds perturbing metabolism are currently
Externí odkaz:
https://doaj.org/article/17259e5ebb3e4107b67d8b9c3eabb2e0
Autor:
Marco Malavolta, Robertina Giacconi, Francesco Piacenza, Sergio Strizzi, Maurizio Cardelli, Giorgia Bigossi, Serena Marcozzi, Luca Tiano, Fabio Marcheggiani, Giulia Matacchione, Angelica Giuliani, Fabiola Olivieri, Ilaria Crivellari, Antonio Paolo Beltrami, Alessandro Serra, Marco Demaria, Mauro Provinciali
Publikováno v:
Cells, Vol 11, Iss 16, p 2506 (2022)
Cellular senescence is a hallmark of aging and a promising target for therapeutic approaches. The identification of senescent cells requires multiple biomarkers and complex experimental procedures, resulting in increased variability and reduced sensi
Externí odkaz:
https://doaj.org/article/5b0c67daf62a40efa7818c4fd46d9fac
Autor:
Shankar J. Chinta, Georgia Woods, Marco Demaria, Anand Rane, Ying Zou, Amanda McQuade, Subramanian Rajagopalan, Chandani Limbad, David T. Madden, Judith Campisi, Julie K. Andersen
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 930-940 (2018)
Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed mechanisms of action have not, however, yielded effective disease therapies. Cellular senescence
Externí odkaz:
https://doaj.org/article/a50111f1811844c78146b1804f884ac5
Publikováno v:
Nature Reviews Clinical Oncology. 19:619-636
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells into senescence can act as a barrier to tumorigenesis and, thus, coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13bb275fb3d2fa26dfcc4d4fb51b688
https://doi.org/10.1038/s41571-022-00668-4
https://doi.org/10.1038/s41571-022-00668-4
Autor:
Christopher D. Wiley, Su Liu, Chandani Limbad, Anna M. Zawadzka, Jennifer Beck, Marco Demaria, Robert Artwood, Fatouma Alimirah, Jose-Alberto Lopez-Dominguez, Chisaka Kuehnemann, Steven R. Danielson, Natan Basisty, Herbert G. Kasler, Tal Ronnen Oron, Pierre-Yves Desprez, Sean D. Mooney, Bradford W. Gibson, Birgit Schilling, Judith Campisi, Pankaj Kapahi
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3329-3337.e5 (2019)
Summary: Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that participates in several age-related diseases. Using stable isotope labeling with amino acids
Externí odkaz:
https://doaj.org/article/18d57d9f49ba45cebd45a0fa32ce2405
Autor:
Annet N. Linders, Itamar B. Dias, Ekaterina S. Ovchinnikova, Mathilde C.S.C. Vermeer, Martijn F. Hoes, George Markousis Mavrogenis, Frederik E. Deiman, Karla F. Arevalo Gomez, Jacqueline M. Bliley, Jamil Nehme, Aryan Vink, Jourik Gietema, Rudolf A. de Boer, Daan Westenbrink, Herman H.W. Sillje, Denise Hilfiker-Kleiner, Linda W. van Laake, Adam W. Feinberg, Marco Demaria, Nils Bomer, Peter van der Meer
Publikováno v:
JACC: CardioOncology.
Background: Doxorubicin is an essential cancer treatment, but its usefulness is hampered by the occurrence of cardiotoxicity. Nevertheless, the pathophysiology underlying doxorubicin-induced cardiotoxicity and the respective molecular mechanisms are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e162f1748f0af6ffa7f0cf129342df
https://doi.org/10.1016/j.jaccao.2023.03.012
https://doi.org/10.1016/j.jaccao.2023.03.012
Autor:
Judith Campisi, Hyman Muss, Norman E. Sharpless, Daohong Zhou, Simon Melov, Brian K. Kennedy, Alain de Bruin, Boshi Wang, Alexis Valdovinos, Sumner Kilmarx, Emmeline C. Academia, Shani Alston, Allison M. Deal, Natalia Mitin, Catherine Le, Kristin Koenig, Fatouma Alimirah, Su Liu, Lijian Shao, Jianhui Chang, Monique N. O'Leary, Marco Demaria
Supplementary Figures S1 - S10, Tables S1 - S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6bd22656c0abacbc1cfe8254992355
https://doi.org/10.1158/2159-8290.22532077.v1
https://doi.org/10.1158/2159-8290.22532077.v1
Autor:
Marta Varela-Eirín, Marco Demaria
Publikováno v:
Current Biology, 32(10), R448-R452. CELL PRESS
Cellular senescence defines a state of stable and generally irreversible proliferative arrest associated with various morphological, structural and functional changes (Figure 1), including enhanced expression and secretion of pro-inflammatory and tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bf8a43e2f805382b0b6eeb1113c8a4
https://doi.org/10.1016/j.cub.2022.04.003
https://doi.org/10.1016/j.cub.2022.04.003