Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Marco, Catto"'
Autor:
Mohammed Eddahmi, Gabriella La Spada, Luis R. Domingo, Gérard Vergoten, Christian Bailly, Marco Catto, Latifa Bouissane
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6803 (2024)
Inhibitors of monoamine oxidases (MAOs) are of interest for the treatment of neurodegenerative disorders and other human pathologies. In this frame, the present work describes different synthetic strategies to obtain MAO inhibitors via the coupling o
Externí odkaz:
https://doaj.org/article/57d29d988b04456299d9feae8301a14b
Autor:
Donia E. Hafez, Mariam Dubiel, Gabriella La Spada, Marco Catto, David Reiner-Link, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Holger Stark, Ashraf H. Abadi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Neurodegenerative diseases such as Alzheimer’s disease (AD) are multifactorial with several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed ligands (MTDLs) which interact with different biological targets relev
Externí odkaz:
https://doaj.org/article/524cab4f650e41a28fe24ba5d6089fe3
Autor:
Alisa A. Nevskaya, Rosa Purgatorio, Tatiana N. Borisova, Alexey V. Varlamov, Lada V. Anikina, Arina Yu. Obydennik, Elena Yu. Nevskaya, Mauro Niso, Nicola A. Colabufo, Antonio Carrieri, Marco Catto, Modesto de Candia, Leonid G. Voskressensky, Cosimo D. Altomare
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 539 (2024)
Previous studies have shown that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in some tumor cells and may
Externí odkaz:
https://doaj.org/article/2d6fcacd9a5e4820a808bb200d14b6c9
Autor:
Rosa Purgatorio, Angelina Boccarelli, Leonardo Pisani, Modesto de Candia, Marco Catto, Cosimo D. Altomare
Publikováno v:
Antioxidants, Vol 13, Iss 1, p 133 (2024)
Polyphenolic compounds, encompassing flavonoids (e.g., quercetin, rutin, and cyanidin) and non-flavonoids (e.g., gallic acid, resveratrol, and curcumin), show several health-related beneficial effects, which include antioxidant, anti-inflammatory, he
Externí odkaz:
https://doaj.org/article/0eb9e2a816ad4e1293498861c7e656bf
Autor:
Leonardo Pisani, Marco Catto, Giovanni Muncipinto, Orazio Nicolotti, Antonio Carrieri, Mariagrazia Rullo, Angela Stefanachi, Francesco Leonetti, Cosimo Altomare
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The coumarin core (i.e., 1-benzopyran-2 (2H)-one) is a structural motif highly recurrent in both natural products and bioactive molecules. Indeed, depending on the substituents and branching positions around the byciclic core, coumarin-containing com
Externí odkaz:
https://doaj.org/article/53ff1d25b4064b7f8ec8c3ec6647bf7d
Autor:
Marco Paolino, Modesto de Candia, Rosa Purgatorio, Marco Catto, Mario Saletti, Anna Rita Tondo, Orazio Nicolotti, Andrea Cappelli, Antonella Brizzi, Claudia Mugnaini, Federico Corelli, Cosimo D. Altomare
Publikováno v:
Molecules, Vol 28, Iss 15, p 5857 (2023)
The multitarget therapeutic strategy, as opposed to the more traditional ‘one disease-one target-one drug’, may hold promise in treating multifactorial neurodegenerative syndromes, such as Alzheimer’s disease (AD) and related dementias. Recentl
Externí odkaz:
https://doaj.org/article/cbf57ecfe1ff483c80c45536adf4d13c
Autor:
Larisa N. Kulikova, Rosa Purgatorio, Andrey A. Beloglazkin, Viktor A. Tafeenko, Raesi Gh. Reza, Daria D. Levickaya, Sabina Sblano, Angelina Boccarelli, Modesto de Candia, Marco Catto, Leonid G. Voskressensky, Cosimo D. Altomare
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7724 (2023)
About twenty molecules sharing 1H-chromeno[3,2-c]pyridine as the scaffold and differing in the degree of saturation of the pyridine ring, oxidation at C10, 1-phenylethynyl at C1 and 1H-indol-3-yl fragments at C10, as well as a few small substituents
Externí odkaz:
https://doaj.org/article/18cc21bf84aa4bdaa025dcc274d8bd92
Publikováno v:
Molbank, Vol 2022, Iss 1, p M1353 (2022)
Based on previously highlighted structural features, the development of highly selective 5-HT1A receptor inhibitors is closely linked to the incorporation of a 4-alkyl-1-arylpiperazine scaffold on them. In this paper, we present the synthesis of two
Externí odkaz:
https://doaj.org/article/23ec3aa23c124227a9b01ba00f1a9875
Autor:
Larisa N. Kulikova, Ghulam Reza Raesi, Daria D. Levickaya, Rosa Purgatorio, Gabriella La Spada, Marco Catto, Cosimo D. Altomare, Leonid G. Voskressensky
Publikováno v:
Molecules, Vol 28, Iss 4, p 1662 (2023)
In this work, 2-alkyl-10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines were obtained and their reactivity was studied. Novel derivatives of the tricyclic scaffold, including 1-phenylethynyl (5), 1-indol-3-yl (8), and azocino[4,5-b]quinoline (1
Externí odkaz:
https://doaj.org/article/6afdb00d129c4f5daa281ef32651b50c
Autor:
Óscar M. Bautista-Aguilera, José M. Alonso, Marco Catto, Isabel Iriepa, Damijan Knez, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Molecules, Vol 27, Iss 21, p 7437 (2022)
Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typi
Externí odkaz:
https://doaj.org/article/8078d56a965e4cc89b09a239954326f4