Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Marcin Szczot"'
Autor:
Laura K. Case, Jaquette Liljencrantz, Nicholas Madian, Aaron Necaise, Justin Tubbs, Micaela McCall, Megan L. Bradson, Marcin Szczot, Mark H. Pitcher, Nima Ghitani, Eleni Frangos, Jonathan Cole, Diana Bharucha-Goebel, Dimah Saade, Tracy Ogata, Sandra Donkervoort, A. Reghan Foley, Carsten G. Bönnemann, Håkan Olausson, M. Catherine Bushnell, Alexander T. Chesler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking Aβ fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations
Externí odkaz:
https://doaj.org/article/b005162b0b26483ea9700b4ecfd44b19
Autor:
Katrin Schrenk-Siemens, Jörg Pohle, Charlotte Rostock, Muad Abd El Hay, Ruby M. Lam, Marcin Szczot, Shiying Lu, Alexander T. Chesler, Jan Siemens
Publikováno v:
Cells, Vol 11, Iss 18, p 2905 (2022)
Somatosensation, the detection and transduction of external and internal stimuli such as temperature or mechanical force, is vital to sustaining our bodily integrity. But still, some of the mechanisms of distinct stimuli detection and transduction ar
Externí odkaz:
https://doaj.org/article/32b7e61ed6dc41b6981cbf3ecae367cb
Autor:
Alec R. Nickolls, Michelle M. Lee, David F. Espinoza, Marcin Szczot, Ruby M. Lam, Qi Wang, Jeanette Beers, Jizhong Zou, Minh Q. Nguyen, Hans J. Solinski, Aisha A. AlJanahi, Kory R. Johnson, Michael E. Ward, Alexander T. Chesler, Carsten G. Bönnemann
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 932-946.e7 (2020)
Summary: Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by overexpressing NGN2 and BRN3A, human pluripoten
Externí odkaz:
https://doaj.org/article/4d1eff25ee1e41209004e08f2fde2c60
Autor:
Marcin Szczot, Leah A. Pogorzala, Hans Jürgen Solinski, Lynn Young, Philina Yee, Claire E. Le Pichon, Alexander T. Chesler, Mark A. Hoon
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2760-2771 (2017)
Summary: Piezo2 is a mechanically activated ion channel required for touch discrimination, vibration detection, and proprioception. Here, we discovered that Piezo2 is extensively spliced, producing different Piezo2 isoforms with distinct properties.
Externí odkaz:
https://doaj.org/article/f9df3ad7e47748a2b8385940e5df0e46
Autor:
Alexander T Chesler, Marcin Szczot
Publikováno v:
eLife, Vol 7 (2018)
Near atomic-resolution structures have provided insights into the mechanisms by which the Piezo1 ion channel senses and responds to mechanical stimuli.
Externí odkaz:
https://doaj.org/article/dfcfa125cde14f219eaa395c17323c13
Autor:
Ardem Patapoutian, Alexander T. Chesler, Jason A. Keller, Marcin Szczot, Carsten G. Bönnemann, Adam Coombs, Ihab Daou, Lisa Stowers, Dimah Saade, Kara L. Marshall, Tracy Ogata, Nima Ghitani
Publikováno v:
Nature
Henry Miller stated that "to relieve a full bladder is one of the great human joys". Urination is critically important in health and ailments of the lower urinary tract cause high pathological burden. Although there have been advances in understandin
Publikováno v:
Annu Rev Biochem
Mechanosensation is the ability to detect dynamic mechanical stimuli (e.g., pressure, stretch, and shear stress) and is essential for a wide variety of processes, including our sense of touch on the skin. How touch is detected and transduced at the m
Autor:
Diana Bharucha-Goebel, Carsten G. Bönnemann, David P. Nguyen, Marta Ceko, Leslie H. Hayes, Carla Grosmann, Christopher B. Stanley, A. Reghan Foley, Katharine E. Alter, Nathaniel Bradley, Sandra Donkervoort, A. Micheil Innes, Cristiane Zampieri, Claire Laubacher, Jean K. Mah, Marcin Szczot, Alexander T. Chesler, Claire E. Le Pichon
Publikováno v:
New England Journal of Medicine. 375:1355-1364
The senses of touch and proprioception evoke a range of perceptions and rely on the ability to detect and transduce mechanical force. The molecular and neural mechanisms underlying these sensory functions remain poorly defined. The stretch-gated ion
Autor:
Marcin Szczot, Jan Siemens, Alexander T. Chesler, Katrin Schrenk-Siemens, Ruby M. Lam, Shiying Lu, Charlotte Rostock, Jörg Pohle, Muad Abd El Hay
Somatosensation, the detection and transduction of external and internal stimuli, has fascinated scientists for centuries. But still, some of the mechanisms how distinct stimuli are detected and transduced are not entirely understood. Over the past d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881820a6e821e155a18f0c3b9ca2dfb5
https://doi.org/10.1101/741660
https://doi.org/10.1101/741660
Autor:
Justin D. Tubbs, Laura K. Case, Eleni Frangos, Diana Bharucha-Goebel, Nima Ghitani, Håkan Olausson, Dimah Saade, Mark H. Pitcher, Jonathan Cole, Nicholas Madian, Aaron Necaise, Micaela V. McCall, Jaquette Liljencrantz, Marcin Szczot, Alexander T. Chesler, Sandra Donkervoort, A. Reghan Foley, Megan Bradson, Tracy Ogata, Carsten G. Bönnemann, M. Catherine Bushnell
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The sensation of pressure allows us to feel sustained compression and body strain. While our understanding of cutaneous touch has grown significantly in recent years, how deep tissue sensations are detected remains less clear. Here, we use quantitati