Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Marcin Pacholczyk"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Among tyrosine kinase inhibitors, quinazoline-based compounds represent a large and well-known group of multi-target agents. Our previous studies have shown interesting kinases inhibition activity for a series of 4-aminostyrylquinazolines based on th
Externí odkaz:
https://doaj.org/article/41592074e8584c39986e5b1bb5927624
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1523-1532 (2023)
Regulatory networks structure and signaling pathways dynamics are uncovered in time- and resource consuming experimental work. However, it is increasingly supported by modeling, analytical and computational techniques as well as discrete mathematics
Externí odkaz:
https://doaj.org/article/bf1af0b70c544509bf70e6d8e0c88f5c
Autor:
Patrycja Przygodzka, Kamila Soboska, Ewelina Sochacka, Marcin Pacholczyk, Marcin Braun, Hassan Kassassir, Izabela Papiewska-Pająk, Michal Kielbik, Joanna Boncela
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Neuromedin U (NMU) was identified as one of the hub genes closely related to colorectal cancer (CRC) progression and was recently shown to be a motility inducer in CRC cells. Its autocrine signalling through specific receptors inc
Externí odkaz:
https://doaj.org/article/af77aad5869f4c03a78c7d79fa083911
Autor:
Patrycja Przygodzka, Ewelina Sochacka, Kamila Soboska, Marcin Pacholczyk, Izabela Papiewska-Pająk, Tomasz Przygodzki, Przemysław Płociński, Steven Ballet, An De Prins, Joanna Boncela
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Abstract Background Successful colorectal cancer (CRC) therapy often depends on the accurate identification of primary tumours with invasive potential. There is still a lack of identified pathological factors associated with disease recurrence that c
Externí odkaz:
https://doaj.org/article/6ffb3fee4b2141b8b26ff681046e9e99
Autor:
Cezary Tręda, Aneta Włodarczyk, Marcin Pacholczyk, Adrianna Rutkowska, Ewelina Stoczyńska-Fidelus, Amelia Kierasińska, Piotr Rieske
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4350 (2023)
The number of glioblastoma (GB) cases is increasing every year, and the currently available therapies remain ineffective. A prospective antigen for GB therapy is EGFRvIII, an EGFR deletion mutant containing a unique epitope that is recognized by the
Externí odkaz:
https://doaj.org/article/b567e51c8ae840fea5318af506b20cc5
Autor:
Karolina Smolinska, Marcin Pacholczyk
Publikováno v:
Biology Direct, Vol 12, Iss 1, Pp 1-8 (2017)
Abstract Background Transcription factor binding affinities to DNA play a key role for the gene regulation. Learning the specificity of the mechanisms of binding TFs to DNA is important both to experimentalists and theoreticians. With the development
Externí odkaz:
https://doaj.org/article/28e3e2d7b5be47a1967273a15d62d797
Autor:
Aleksandra Poterala-Hejmo, Adam Golda, Marcin Pacholczyk, Sebastian Student, Anna Tylki-Szymańska, Anna Lalik
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 4913 (2020)
Perturbations of glycosaminoglycan metabolism lead to mucopolysaccharidoses (MPS)—lysosomal storage diseases. One type of MPS (type VI) is associated with a deficiency of arylsulfatase B (ARSB), for which we previously established a cellular model
Externí odkaz:
https://doaj.org/article/b6c36ef913954a908b6320fbbe7e13bc
Publikováno v:
Expert opinion on drug discovery. 17(3)
The fused aromatic system of terpyridines makes them good, innocent ligands for various metals. The resulting complexes have been extensively studied for both their biological activity and physico-chemical properties. However, although free ligands a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16adafcab29e598db68deff8ef4e81cf
https://pubmed.ncbi.nlm.nih.gov/34928186
https://pubmed.ncbi.nlm.nih.gov/34928186
Autor:
Tomasz Przygodzki, Patrycja Przygodzka, Marcin Pacholczyk, Izabela Papiewska-Pająk, Ewelina Sochacka, Kamila Soboska, Steven Ballet, An De Prins, Joanna Boncela, Przemysław Płociński
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
BackgroundSuccessful colorectal cancer (CRC) therapy often depends on the accurate identification of primary tumours with invasive potential. There is still a lack of identified pathological factors associated with disease recurrence that could help
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ff6958d4dbafcabe0d8bdd1e6727ba
https://doi.org/10.1186/s13046-021-02073-8
https://doi.org/10.1186/s13046-021-02073-8
Autor:
Magdalena Ługowska, Marcin Pacholczyk
Publikováno v:
F1000Research. 10:1236
Background: Difficulties in translating the in vitro potency determined by cellular assays into in vivo efficacy in living organisms complicates the design and development of drugs. However, the residence time of a drug in its molecular target is bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fe936cf4d0b822f683af7902a1504d
https://doi.org/10.12688/f1000research.73420.2
https://doi.org/10.12688/f1000research.73420.2