Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Marcin Nowotny"'
Autor:
Maria Kuzikov, Jeanette Reinshagen, Krzysztof Wycisk, Angela Corona, Francesca Esposito, Paolo Malune, Candida Manelfi, Daniela Iaconis, Andrea Beccari, Enzo Tramontano, Marcin Nowotny, Björn Windshügel, Philip Gribbon, Andrea Zaliani
Publikováno v:
Virus Research, Vol 343, Iss , Pp 199356- (2024)
Coronaviruses contain one of the largest genomes among the RNA viruses, coding for 14–16 non-structural proteins (nsp) that are involved in proteolytic processing, genome replication and transcription, and four structural proteins that build the co
Externí odkaz:
https://doaj.org/article/550094371ce149a49691d7b4b0ad8bf8
Autor:
Sergii Palchevskyi, Mariusz Czarnocki-Cieciura, Giulio Vistoli, Silvia Gervasoni, Elżbieta Nowak, Andrea R. Beccari, Marcin Nowotny, Carmine Talarico
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. It is a therapeutic target for anticancer dru
Externí odkaz:
https://doaj.org/article/31f8f5e556c94b7bb6972a673520f71c
Autor:
Karolina Maria Górecka, Miroslav Krepl, Aleksandra Szlachcic, Jarosław Poznański, Jiří Šponer, Marcin Nowotny
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Holliday junctions (HJs) are four-way DNA structures that occur in DNA repair by homologous recombination which are removed by nucleases such as RuvC. Here the authors provide structural and biochemical details on the steps required for the completio
Externí odkaz:
https://doaj.org/article/ee4f387405724f7facf85dd79c1e37a1
Autor:
Michal Razew, Zbigniew Warkocki, Michal Taube, Adam Kolondra, Mariusz Czarnocki-Cieciura, Elzbieta Nowak, Karolina Labedzka-Dmoch, Aleksandra Kawinska, Jakub Piatkowski, Pawel Golik, Maciej Kozak, Andrzej Dziembowski, Marcin Nowotny
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The mitochondrial RNA degradosome (mtEXO) plays an essential role in the regulation of mitochondrial gene expression and is composed of the 3′-to-5′ exoribonuclease Dss1 and the helicase Suv3. Here the authors present the RNA bound mtEXO crystal
Externí odkaz:
https://doaj.org/article/a49d6a6a537d4790acaf1b909466f3e5
Autor:
Piotr Pankiewicz, Marcin Szybiński, Katarzyna Kisielewska, Filip Gołębiowski, Patryk Krzemiński, Izabela Rutkowska-Włodarczyk, Rafał Moszczyński-Pętkowski, Lidia Gurba-Bryśkiewicz, Monika Delis, Krzysztof Mulewski, Damian Smuga, Jakub Dominowski, Artur Janusz, Michał Górka, Krzysztof Abramski, Agnieszka Napiórkowska, Marcin Nowotny, Krzysztof Dubiel, Katarzyna Kalita, Maciej Wieczorek, Jerzy Pieczykolan, Mikołaj Matłoka
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 704 (2021)
TrkB is a tyrosine kinase receptor that is activated upon binding to brain-derived neurotrophic factor (BDNF). To date, the search for low-molecular-weight molecules mimicking BDNF’s action has been unsuccessful. Several molecules exerting antidepr
Externí odkaz:
https://doaj.org/article/9bb1dda14c4f450caccc553dfbb7d53e
Autor:
Mathew Stracy, Marcin Jaciuk, Stephan Uphoff, Achillefs N. Kapanidis, Marcin Nowotny, David J. Sherratt, Pawel Zawadzki
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nucleotide excision repair is able to identify and remove a wide range of DNA helix distorting lesions from the genome. Here the authors use single molecule imaging of UvrA and UvrB molecules and suggest a two-step ‘scan and recruit’ model for Uv
Externí odkaz:
https://doaj.org/article/1fdccc86530b44ceb8758d17f008c0d5
Autor:
Vineet Gaur, Haley D.M. Wyatt, Weronika Komorowska, Roman H. Szczepanowski, Daniele de Sanctis, Karolina M. Gorecka, Stephen C. West, Marcin Nowotny
Publikováno v:
Cell Reports, Vol 10, Iss 9, Pp 1467-1476 (2015)
The SLX1-SLX4 endonuclease required for homologous recombination and DNA repair in eukaryotic cells cleaves a variety of branched DNA structures. The nuclease subunit SLX1 is activated by association with a scaffolding protein SLX4. At the present ti
Externí odkaz:
https://doaj.org/article/f0d4ce1319024879b7c0e7495e866bf1
Autor:
Bartlomiej Borek, Julita Nowicka, Anna Gzik, Marek Dziegielewski, Karol Jedrzejczak, Joanna Brzezinska, Marcin Grzybowski, Paulina Stanczak, Paulina Pomper, Agnieszka Zagozdzon, Tomasz Rejczak, Krzysztof Matyszewski, Adam Golebiowski, Jacek Olczak, Kamil Lisiecki, Magdalena Tyszkiewicz, Magdalena Kania, Sylwia Piasecka, Anna Cabaj, Paulina Dera, Krzysztof Mulewski, Jacek Chrzanowski, Damian Kusmirek, Elzbieta Sobolewska, Marta Magdycz, Lukasz Mucha, Marek Masnyk, Jakub Golab, Marcin Nowotny, Elzbieta Nowak, Agnieszka Napiorkowska-Gromadzka, Stanislaw Pikul, Radoslaw Jazwiec, Karolina Dzwonek, Pawel Dobrzanski, Michael Meyring, Krzysztof Skowronek, Piotr Iwanowski, Zbigniew Zaslona, Roman Blaszczyk
Publikováno v:
Molecular Cancer Therapeutics.
Pharmacological inhibition of the controlling immunity pathway enzymes arginases 1 and 2 (ARG1 and ARG2) is a promising strategy for cancer immunotherapy. Here, we report the discovery and development of OATD-02, an orally bioavailable, potent argina
Autor:
Malwina Hyjek-Składanowska, Brooke A Anderson, Vitaliy Mykhaylyk, Christian Orr, Armin Wagner, Jarosław T Poznański, Krzysztof Skowronek, Punit Seth, Marcin Nowotny
Publikováno v:
Nucleic acids research 51(3), 1409-1423 (2023). doi:10.1093/nar/gkac774
Nucleic Acid Research
Nucleic Acid Research
Nucleic acids research / Special publication xx, gkac774 (2022). doi:10.1093/nar/gkac774
The introduction of phosphorothioate (PS) linkages to the backbone of therapeutic nucleic acids substantially increases their stability and potency. It also
The introduction of phosphorothioate (PS) linkages to the backbone of therapeutic nucleic acids substantially increases their stability and potency. It also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1d6084c87d74be5b9030f61ce79892
https://bib-pubdb1.desy.de/record/490739
https://bib-pubdb1.desy.de/record/490739
Autor:
Sergii Palchevskyi, Mariusz Czarnocki-Cieciura, Giulio Vistoli, Silvia Gervasoni, Elżbieta Nowak, Andrea R. Beccari, Marcin Nowotny, Carmine Talarico
TRPM8 is a calcium ion channel that is activated by multiple factors, such as temperature, voltage, pressure, and osmolality. It is a therapeutic target for anticancer drug development, and its modulators can be utilized for several pathological cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53710022f47e167951b2c42b66bf53b0
https://doi.org/10.1101/2022.10.19.512915
https://doi.org/10.1101/2022.10.19.512915