Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Marcin Kortylewski"'
Autor:
Jeremy Hall, Zhuoran Zhang, Supriyo Bhattacharya, Dongfang Wang, Marice Alcantara, Yong Liang, Piotr Swiderski, Stephen Forman, Larry Kwak, Nagarajan Vaidehi, Marcin Kortylewski
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102137- (2024)
Decoy oligodeoxynucleotides (ODNs) allow targeting undruggable transcription factors, such as STAT3, but their limited potency and lack of delivery methods hampered translation. To overcome these challenges, we conjugated a STAT3-specific decoy to th
Externí odkaz:
https://doaj.org/article/131de0a661da4c95890883064a5927cd
Autor:
Bin Zhang, Dandan Zhao, Fang Chen, David Frankhouser, Huafeng Wang, Khyatiben V. Pathak, Lei Dong, Anakaren Torres, Krystine Garcia-Mansfield, Yi Zhang, Dinh Hoa Hoang, Min-Hsuan Chen, Shu Tao, Hyejin Cho, Yong Liang, Danilo Perrotti, Sergio Branciamore, Russell Rockne, Xiwei Wu, Lucy Ghoda, Ling Li, Jie Jin, Jianjun Chen, Jianhua Yu, Michael A. Caligiuri, Ya-Huei Kuo, Mark Boldin, Rui Su, Piotr Swiderski, Marcin Kortylewski, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of miR-142 in CD34+CD38− blasts from BC CML patients than in t
Externí odkaz:
https://doaj.org/article/883dc5faaf3c4abe8121ce71d3dc31ce
Autor:
Amit Sharma, Diogo C. Fernandes, Rui L. Reis, Dominika Gołubczyk, Silke Neumann, Barbara Lukomska, Miroslaw Janowski, Marcin Kortylewski, Piotr Walczak, J. Miguel Oliveira, Jarek Maciaczyk
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drug
Externí odkaz:
https://doaj.org/article/8501d0a072824dcf8d51d5f71cc023f1
Autor:
Marice B. Alcantara, Wilson S. Tang, Dongfang Wang, Damian Kaniowski, Elaine Kang, Nazli Dizman, Alexander Chehrazi-Raffle, Luis Meza, Zeynep Zengin, Jeremy Hall, JoAnn Hsu, Colt Egelston, Dayson Moreira, Alan Horsager, Sumanta K. Pal, Marcin Kortylewski
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionImmune checkpoint blockade (ICB) improved clinical outcomes in renal and bladder cancer patients, but the response rates remain limited especially in metastatic disease. While STAT3 transcription factor is well-known master regulator of t
Externí odkaz:
https://doaj.org/article/dd84707eb9c14a5ba4ee11901b173fa0
Autor:
Marcin Kortylewski, Behnam Badie, Amy Heimberger, Chia-Yang Hung, Bozena Kaminska, Xiaowei Zhang, Elaine Kang, Karol Jacek, Chunsong Yu, Susanta Hui
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/541b803a3ec7476cb22509119af83149
Autor:
Carla L. Esposito, Ida Autiero, Annamaria Sandomenico, H. Li, Mahmoud A. Bassal, Maria L. Ibba, Dongfang Wang, Lucrezia Rinaldi, Simone Ummarino, Giulia Gaggi, Marta Borchiellini, Piotr Swiderski, Menotti Ruvo, Silvia Catuogno, Alexander K. Ebralidze, Marcin Kortylewski, Vittorio de Franciscis, Annalisa Di Ruscio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Here the authors generate an RNA-based platform to neutralize the major epigenetic player DNMT1. Using this targeted approach, aberrant DNA methylation in cancer can be corrected.
Externí odkaz:
https://doaj.org/article/1ac7b00822ad42efaffe5d498c64c726
Autor:
Tomasz Adamus, Chia-Yang Hung, Chunsong Yu, Elaine Kang, Mohamed Hammad, Linda Flores, Sergey Nechaev, Qifang Zhang, Joanna Marie Gonzaga, Kokilah Muthaiyah, Piotr Swiderski, Karen S. Aboody, Marcin Kortylewski
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 611-620 (2022)
Tropism of neural stem cells (NSCs) to hypoxic tumor areas provides an opportunity for the drug delivery. Here, we demonstrate that NSCs effectively transport antisense oligonucleotides (ASOs) targeting oncogenic and tolerogenic signal transducer and
Externí odkaz:
https://doaj.org/article/2c3ff6cf67da44afa64366d79036cbde
Autor:
Lianjun Zhang, Le Xuan Truong Nguyen, Ying-Chieh Chen, Dijiong Wu, Guerry J. Cook, Dinh Hoa Hoang, Casey J. Brewer, Xin He, Haojie Dong, Shu Li, Man Li, Dandan Zhao, Jing Qi, Wei-Kai Hua, Qi Cai, Emily Carnahan, Wei Chen, Xiwei Wu, Piotr Swiderski, Russell C. Rockne, Marcin Kortylewski, Ling Li, Bin Zhang, Guido Marcucci, Ya-Huei Kuo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
miR-126 is highly expressed in inv(16) Acute myeloid leukemia (AML) but its role is unclear. Here, the authors show that the aberrant expression of miR-126 in inv(16) AML is directly due to the CBFB-MYH11 fusion gene and that it can promote AML devel
Externí odkaz:
https://doaj.org/article/ba8150db19cd424e95fcc1bef2ef61ff
Autor:
Bin Zhang, Le Xuan Truong Nguyen, Dandan Zhao, David E. Frankhouser, Huafeng Wang, Dinh Hoa Hoang, Junjing Qiao, Christina Abundis, Matthew Brehove, Yu-Lin Su, Yuxin Feng, Anthony Stein, Lucy Ghoda, Adrianne Dorrance, Danilo Perrotti, Zhen Chen, Anjia Han, Flavia Pichiorri, Jie Jin, Tijana Jovanovic-Talisman, Michael A. Caligiuri, Calvin J. Kuo, Akihiko Yoshimura, Ling Li, Russell C. Rockne, Marcin Kortylewski, Yi Zheng, Nadia Carlesso, Ya-Huei Kuo, Guido Marcucci
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Background During acute myeloid leukemia (AML) growth, the bone marrow (BM) niche acquires significant vascular changes that can be offset by therapeutic blast cytoreduction. The molecular mechanisms of this vascular plasticity remain to be
Externí odkaz:
https://doaj.org/article/52f9905cc5f14aa08a70fe465bcdd2b1
Autor:
Farouk Nouizi, Jamison Brooks, Darren M. Zuro, Srideshikan Sargur Madabushi, Dayson Moreira, Marcin Kortylewski, Jerry Froelich, Lydia M. Su, Gultekin Gulsen, Susanta K. Hui
Publikováno v:
IEEE Access, Vol 8, Pp 93663-93670 (2020)
Hypofractionated stereotactic body radiotherapy treatments (SBRT) have demonstrated impressive results for the treatment of a variety of solid tumors. The role of tumor supporting vasculature damage in treatment outcome for SBRT has been intensely de
Externí odkaz:
https://doaj.org/article/d09dc650ed1047f2aae7354c3163830f