Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marcin J Szafran"'
Spatial rearrangement of the Streptomyces venezuelae linear chromosome during sporogenic development
Autor:
Marcin J. Szafran, Tomasz Małecki, Agnieszka Strzałka, Katarzyna Pawlikiewicz, Julia Duława, Anna Zarek, Agnieszka Kois-Ostrowska, Kim C. Findlay, Tung B. K. Le, Dagmara Jakimowicz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Streptomyces bacteria have a linear chromosome and a complex life cycle, including development of multi-genomic hyphae that differentiate into mono-genomic exospores. Here, Szafran et al. show that the chromosome of Streptomyces venezuelae undergoes
Externí odkaz:
https://doaj.org/article/9766f0380f5e4e4a8dcdc34cfb142868
Autor:
Martyna Gongerowska-Jac, Marcin J. Szafran, Jakub Mikołajczyk, Justyna Szymczak, Magdalena Bartyńska, Anna Gierlikowska, Sylwia Biały, Marie A. Elliot, Dagmara Jakimowicz
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT Bacterial gene expression is controlled at multiple levels, with chromosome supercoiling being one of the most global regulators. Global DNA supercoiling is maintained by the orchestrated action of topoisomerases. In Streptomyces, mycelial s
Externí odkaz:
https://doaj.org/article/3009ee8b58154fd29b1b23b40bf1533f
Autor:
Agnieszka Strzałka, Agnieszka Kois-Ostrowska, Magda Kędra, Tomasz Łebkowski, Grażyna Bieniarz, Marcin J Szafran, Dagmara Jakimowicz
Publikováno v:
Nucleic Acids Research. 50:12202-12216
Bacterial chromosome topology is controlled by topoisomerases and nucleoid-associated proteins (NAPs). While topoisomerases regulate DNA supercoiling, NAPs introduce bends or coat DNA upon its binding, affecting DNA loop formation. Streptomyces, hyph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f447bdb8cd679805f1352e6225564da
https://doi.org/10.1093/nar/gkac1093
https://doi.org/10.1093/nar/gkac1093
Autor:
Marcin J. Szafran, Tomasz Małecki, Agnieszka Strzałka, Katarzyna Pawlikiewicz, Julia Duława, Anna Zarek, Agnieszka Kois-Ostrowska, Kim C. Findlay, Tung B. K. Le, Dagmara Jakimowicz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/fd0da7c2332e4b57a7a28a69d3686d09
Autor:
Marcin J. Szafran, Marta Kołodziej, Patrycja Skut, Brahmam Medapi, Agnieszka Domagała, Damian Trojanowski, Jolanta Zakrzewska-Czerwińska, Dharmarajan Sriram, Dagmara Jakimowicz
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Amsacrine, which inhibits eukaryotic type II topoisomerase via DNA intercalation and stabilization of the cleavable topoisomerase-DNA complex, promotes DNA damage and eventually cell death. Amsacrine has also been shown to inhibit structurally distin
Externí odkaz:
https://doaj.org/article/a395701bfbea415994509b2458e20d7b
Publikováno v:
FEMS Microbiol Rev
Chromosomes are dynamic entities, whose organization and structure depend on the concerted activity of DNA-binding proteins and DNA-processing enzymes. In bacteria, chromosome replication, segregation, compaction and transcription are all occurring s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9bced0330446181edf139610d7687a9
https://doi.org/10.1093/femsre/fuaa028
https://doi.org/10.1093/femsre/fuaa028
Publikováno v:
Microbiology
Topoisomerase I (TopA) is an essential enzyme that is required to remove excess negative supercoils from chromosomal DNA. Actinobacteria encode unusual TopA homologues with a unique C-terminal domain that contains lysine repeats and confers high enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d30d568c4cfabc435429707aa343d6c
https://doi.org/10.1099/mic.0.000841
https://doi.org/10.1099/mic.0.000841
Autor:
Anna Gierlikowska, Magdalena Bartyńska, Sylwia Biały, Marcin J. Szafran, Martyna Gongerowska-Jac, Dagmara Jakimowicz, Justyna Szymczak, Jakub Mikołajczyk, Marie A. Elliot
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
mSystems
mSystems
Bacterial gene expression is controlled at multiple levels, with chromosome supercoiling being one of the most global regulators. Global DNA supercoiling is maintained by the orchestrated action of topoisomerases. In Streptomyces, mycelial soil bacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2856b1dcc2fb41e4ca39663219377b35
https://journals.asm.org/doi/10.1128/mSystems.01142-21
https://journals.asm.org/doi/10.1128/mSystems.01142-21
Autor:
Kim Findlay, Katarzyna Pawlikiewicz, Dagmara Jakimowicz, Marcin J. Szafran, Anna Zarek, Tung B. K. Le, Tomasz Małecki, Agnieszka Kois-Ostrowska, Agnieszka Strzałka, Julia Duława
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8868969bf1ccd881f75afb31826106f9
https://doi.org/10.1038/s41467-021-25897-6
https://doi.org/10.1038/s41467-021-25897-6
Publikováno v:
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-15 (2021)
Microbial Cell Factories
Microbial Cell Factories
Background Identifying the regulatory factors that control transcriptional activity is a major challenge of gene expression studies. Here, we describe the application of a novel approach for in vivo identification of regulatory proteins that may dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::befd0b0be5b6b862f9aa2758c954fe2f
https://doi.org/10.21203/rs.3.rs-321607/v1
https://doi.org/10.21203/rs.3.rs-321607/v1
