Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Marcin Grabowicz"'
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT The outer membrane (OM) is an essential organelle of Gram-negative bacteria. Lipoproteins are key to building the OM, performing essential functions in several OM assembly machines. Lipoproteins mature in the inner membrane (IM) and are then
Externí odkaz:
https://doaj.org/article/d1f08c7cf8b14bc5bb2bff817bfa8a2a
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT The outer membrane (OM) of Gram-negative bacteria is an essential organelle that acts as a formidable barrier to antibiotics. Increasingly prevalent resistance to existing drugs has exacerbated the need for antibiotic discovery efforts targe
Externí odkaz:
https://doaj.org/article/e652fba015664c67b4f6442c9f1e4d3b
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Gram-negative bacteria produce lipid-anchored lipoproteins that are trafficked to their outer membrane (OM). These lipoproteins are essential components in each of the molecular machines that build the OM, including the Bam machine that asse
Externí odkaz:
https://doaj.org/article/7cbc509f760b4c7ea83e858cf69fcb8c
Autor:
Kelly M. Lehman, Marcin Grabowicz
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 163 (2019)
Gram-negative bacteria shield themselves from antibiotics by producing an outer membrane (OM) that forms a formidable permeability barrier. Multidrug resistance among these organisms is a particularly acute problem that is exacerbated by the OM. The
Externí odkaz:
https://doaj.org/article/6d27295192f148c380977d0888c45dde
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT The promoter most strongly induced upon activation of the Cpx two-component envelope stress response is the cpxP promoter. The 3′ untranscribed region (UTR) of the cpxP transcript is shown to produce a small RNA (sRNA), CpxQ. We investigat
Externí odkaz:
https://doaj.org/article/335b07cec21a4f4ea993af86a204d444
Autor:
Marcin Grabowicz, Dorothee Andres, Matthew D Lebar, Goran Malojčić, Daniel Kahne, Thomas J Silhavy
Publikováno v:
eLife, Vol 3 (2014)
The lipopolysaccharide (LPS) forms the surface-exposed leaflet of the outer membrane (OM) of Gram-negative bacteria, an organelle that shields the underlying peptidoglycan (PG) cell wall. Both LPS and PG are essential cell envelope components that ar
Externí odkaz:
https://doaj.org/article/3f87990e42e34d8e8767d7d185821ac9
Publikováno v:
Molecular Microbiology. 119:586-598
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a194b860fde33debd00e9f06d1a99f0
https://doi.org/10.1111/mmi.15054
https://doi.org/10.1111/mmi.15054
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The outer membrane (OM) is the defining feature of gram-negative bacteria and is an essential organelle. Accordingly, OM assembly pathways and their essential protein components are conserved throughout all gram-negative species. Lipoprotein traffick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79201e13e57416746b70acf1a71fdafb
https://doi.org/10.1073/pnas.2218473120
https://doi.org/10.1073/pnas.2218473120
Autor:
Marcin Grabowicz, David S Weiss
Publikováno v:
Current Opinion in Microbiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a5ab5d97a338c8ae3f72ef74bd9346
https://pubmed.ncbi.nlm.nih.gov/35067292
https://pubmed.ncbi.nlm.nih.gov/35067292
Autor:
David Tomasek, Marcin Grabowicz, Thomas J. Silhavy, Christine L. Hagan, Joseph S. Wzorek, Michael D. Mandler, Daniel Kahne, James Lee, Elizabeth M. Hart, Mary D May, Holly A. Sutterlin
Publikováno v:
Proceedings of the National Academy of Sciences. 115:2359-2364
The β-barrel assembly machine (Bam) complex folds and inserts integral membrane proteins into the outer membrane of Gram-negative bacteria. The two essential components of the complex, BamA and BamD, both interact with substrates, but how the two co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31d4feedd5d8c18c61981536bdfa67c
https://doi.org/10.1073/pnas.1711727115
https://doi.org/10.1073/pnas.1711727115