Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Marcin Bugno"'
Autor:
Z Beau Reneer, Harrison C Bergeron, Stephen Reynolds, Elena Thornhill-Wadolowski, Lan Feng, Marcin Bugno, Agnieszka D Truax, Ralph A Tripp
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0297833 (2024)
Influenza viruses cause epidemics and can cause pandemics with substantial morbidity with some mortality every year. Seasonal influenza vaccines have incomplete effectiveness and elicit a narrow antibody response that often does not protect against m
Externí odkaz:
https://doaj.org/article/8cca0fe77205435b98ee37f83f17170a
Autor:
Agnieszka Banbula, Jan Potempa, Robert N. Pike, Aneta Sroka, James Travis, Marcin Bugno, Yusuke Takahashi, Caroline A. Genco, Maryta Sztukowska
Publikováno v:
Molecular Microbiology. 54:1393-1408
The Porphyromonas gingivalis lysine-specific cysteine protease (gingipain K, Kgp) is expressed as a large precursor protein consisting of a leader sequence, a pro-fragment, a catalytic domain with a C-terminal IgG-like subdomain (IgSF) and a large ha
Publikováno v:
Molecular Microbiology. 44:479-488
Rubrerythrins are non-haem iron proteins that have been implicated in oxidative stress protection in anaerobic bacteria and archaea. However, up to now, this role has not been confirmed directly by inactivation of a rubrerythrin gene. Here we report
Autor:
Nicola A. Woodcock, Paul Hooley, Julia B. Barham-Morris, Michael P. Whitehead, D Clement, Michele S. Stanley, John D. O'Neil, Nicholas Clipson, Daron A. Fincham, Marcin Bugno
Publikováno v:
Mycological Research. 106:491-498
We report the cloning and sequencing of a DNA fragment encoding a putative C 2 H 2 zinc finger protein from Aspergillus nidulans. The gene was isolated by complementation cloning of a salt sensitive phenotype of the A. nidulans sltAl mutant. A 3.8 kb
Publikováno v:
Microbial Pathogenesis. 32:173-181
Current consensus is that periodontitis is an infectious disease in which a deregulated chronic inflammatory reaction not only may lead to periodontal tissue damage but also eventually may cause tooth loss. In controlling the inflammatory state the i
Publikováno v:
The Journal of Neuroscience. 20:7510-7516
The expression of α1-antichymotrypsin (ACT) is significantly enhanced in affected brain regions in Alzheimer's disease. This serine proteinase inhibitor specifically colocalizes with filamentous β-amyloid deposits and recently has been shown to inf
Autor:
Daniel C. Nelson, Jan Potempa, Jane Yen, Marcin Bugno, James Travis, Agnieszka Banbula, Jason Goldstein
Publikováno v:
Infection and Immunity. 68:1176-1182
Porphyromonas gingivalis is an asaccharolytic and anaerobic bacterium that possesses a complex proteolytic system which is essential for its growth and evasion of host defense mechanisms. In this report, we show the purification and characterization
Publikováno v:
Biochemical and Biophysical Research Communications. 267:329-333
Progression of inflammatory processes correlates with the release of cell-derived mediators from the local site of inflammation. These mediators, including cytokines of the IL-1 and IL-6 families, act on host cells and exert their action by activatin
Publikováno v:
Biochemical and Biophysical Research Communications. 261:598-602
Deregulation of the cytokine network is an important adaptation of pathogenic bacteria to modulate and evade a host immune response. Here we describe that IL-6 is rapidly and efficiently cleaved and inactivated by the arginine- and lysine-specific pr
Autor:
Jerzy Silberring, Adam Dubin, Jan Potempa, Marcin Bugno, Daniel C. Nelson, James Travis, Agnieszka Banbula, Paweł Mak
Publikováno v:
Journal of Biological Chemistry. 274:9246-9252
Porphyromonas gingivalis possesses a complex proteolytic system, which is essential for both its growth and evasion of host defense mechanisms. In this report we characterized, both at a protein and genomic level, a novel peptidase of this system wit