Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Marcin, Krzystanek"'
Autor:
Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nousome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell A. Sesterhenn, Joel T. Moncur, Gregory T. Chesnut, Gyorgy Petrovics, Gregory T. Klus, Gabor Valcz, Pier Vitale Nuzzo, Dezso Ribli, Judit Börcsök, Aurel Prosz, Marcin Krzystanek, Thomas Ried, David Szuts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D. D’Andrea, Istvan Csabai, Shiv Srivastava, Matthew L. Freedman, Albert Dobi, Sandor Spisak, Zoltan Szallasi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)
Abstract We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1
Externí odkaz:
https://doaj.org/article/3508a45a6daf4e298c016ff52086528b
Autor:
Miklos Diossy, Zsofia Sztupinszki, Judit Borcsok, Marcin Krzystanek, Viktoria Tisza, Sandor Spisak, Orsolya Rusz, Jozsef Timar, István Csabai, Janos Fillinger, Judit Moldvay, Anders Gorm Pedersen, David Szuts, Zoltan Szallasi
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021)
Abstract PARP inhibitors are approved for the treatment of solid tumor types that frequently harbor alterations in the key homologous recombination (HR) genes, BRCA1/2. Other tumor types, such as lung cancer, may also be HR deficient, but the frequen
Externí odkaz:
https://doaj.org/article/406462c44b26424ba7040c4796c0ef2d
Autor:
Zoltan Szallasi, Matthew L. Freedman, István Csabai, Orsolya Rusz, Sandor Spisak, Viktoria Tisza, Mark M. Pomerantz, Judit Borcsok, Marcin Krzystanek, Miklos Diossy, Zsofia Sztupinszki
Supplementary Data from Detection of Molecular Signatures of Homologous Recombination Deficiency in Prostate Cancer with or without BRCA1/2 Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dd925a49a2911e33a0afc6e2dd0dda
https://doi.org/10.1158/1078-0432.22480010.v1
https://doi.org/10.1158/1078-0432.22480010.v1
Autor:
Zoltan Szallasi, Matthew L. Freedman, István Csabai, Orsolya Rusz, Sandor Spisak, Viktoria Tisza, Mark M. Pomerantz, Judit Borcsok, Marcin Krzystanek, Miklos Diossy, Zsofia Sztupinszki
Purpose:Prostate cancers with mutations in genes involved in homologous recombination (HR), most commonly BRCA2, respond favorably to PARP inhibition and platinum-based chemotherapy. We investigated whether other prostate tumors that do not harbor de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193e3d9213d9b5575312c621571bfbd1
https://doi.org/10.1158/1078-0432.c.6530351
https://doi.org/10.1158/1078-0432.c.6530351
Autor:
Ying Su, Ashim Subedee, Noga Bloushtain-Qimron, Virginia Savova, Marcin Krzystanek, Lewyn Li, Andriy Marusyk, Doris P. Tabassum, Alexander Zak, Mary Jo Flacker, Mei Li, Jessica J. Lin, Saraswati Sukumar, Hiromu Suzuki, Henry Long, Zoltan Szallasi, Alexander Gimelbrant, Reo Maruyama, Kornelia Polyak
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1549-1563 (2015)
Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generat
Externí odkaz:
https://doaj.org/article/6f15bf7525f7429da61f9bca90408f78
Autor:
István Csabai, Judit Moldvay, János Fillinger, Zoltan Szallasi, Viktoria Tisza, Anders Gorm Pedersen, Marcin Krzystanek, Dávid Szüts, Miklos Diossy, Orsolya Rusz, Zsofia Sztupinszki, Judit Borcsok, József Tímár, Sándor Spisák
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021)
NPJ Precision Oncology
Diossy, M, Sztupinszki, Z, Borcsok, J, Krzystanek, M, Tisza, V, Spisak, S, Rusz, O, Timar, J, Csabai, I, Fillinger, J, Moldvay, J, Pedersen, A G, Szuts, D & Szallasi, Z 2021, ' A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures ', n p j Precision Oncology, vol. 5, no. 1, 55 . https://doi.org/10.1038/s41698-021-00199-8
NPJ Precision Oncology
Diossy, M, Sztupinszki, Z, Borcsok, J, Krzystanek, M, Tisza, V, Spisak, S, Rusz, O, Timar, J, Csabai, I, Fillinger, J, Moldvay, J, Pedersen, A G, Szuts, D & Szallasi, Z 2021, ' A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures ', n p j Precision Oncology, vol. 5, no. 1, 55 . https://doi.org/10.1038/s41698-021-00199-8
BackgroundConsistent with their assumed mechanism of action, PARP inhibitors show significant therapeutic efficacy in breast, ovarian and prostate cancer, which are the solid tumor types most often associated with the loss of function of key homologo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8487d7c44c3decc857387b2118d044
https://doaj.org/article/406462c44b26424ba7040c4796c0ef2d
https://doaj.org/article/406462c44b26424ba7040c4796c0ef2d
Autor:
Matthew L. Freedman, Mark Pomerantz, Orsolya Rusz, Zsofia Sztupinszki, Sándor Spisák, Viktoria Tisza, Marcin Krzystanek, Miklos Diossy, Judit Borcsok, Zoltan Szallasi, István Csabai
Publikováno v:
Clin Cancer Res
Purpose: Prostate cancers with mutations in genes involved in homologous recombination (HR), most commonly BRCA2, respond favorably to PARP inhibition and platinum-based chemotherapy. We investigated whether other prostate tumors that do not harbor d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab2fd003cb36f7c422a938b5eac7bb6
https://doi.org/10.1158/1078-0432.ccr-19-2135
https://doi.org/10.1158/1078-0432.ccr-19-2135
Publikováno v:
F1000Research, Vol 3 (2014)
Thrombocytosis portends adverse prognostic significance in many types of cancers including ovarian and lung carcinoma. In this study, we determined the prevalence and prognostic significance of thrombocytosis (defined as platelet count in excess of 4
Externí odkaz:
https://doaj.org/article/04f0e9a3cfd54b05a87382b3d33d3ca4
Autor:
Isabell A. Sesterhenn, Aurel Prosz, Pier Vitale Nuzzo, Aimilia Schina, Dobi A, Jia Zhou, Hongzhen Li, István Csabai, Ebner R, Dezso Ribli, Salma Kaochar, Dávid Szüts, Denise Young, Ried T, Sándor Spisák, Gábor Valcz, Pathania S, Darryl Nousome, Shweta Srivastava, Joel T. Moncur, Zsofia Sztupinszki, Yongmei Chen, Claire Kuo, Gyorgy Petrovics, Alan D. D'Andrea, Judit Borcsok, Marcin Krzystanek, Zoltan Szallasi, Miklos Diossy, Klus Gt, Matthew L. Freedman, Tisza, Gregory T. Chesnut
BackgroundAfrican American (AA) men have significantly higher mortality rates from prostate cancer (PC) than individuals of European ancestry (EA). Therapeutically targetable molecular differences may hold the potential to reduce this disparity.Objec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b029bcc59373875def46e0af5460001f
https://doi.org/10.1101/2021.02.08.21251199
https://doi.org/10.1101/2021.02.08.21251199
Autor:
Marcin Krzystanek, Aron Charles Eklund, István Csabai, Miklos Diossy, Anders Gorm Pedersen, Zoltan Szallasi, Zsofia Sztupinszki, Judit Borcsok
Publikováno v:
Briefings in bioinformatics. 22(6)
Formalin-fixed paraffin-embedded tissue, the most common tissue specimen stored in clinical practice, presents challenges in the analysis due to formalin-induced artifacts. Here, we present Strand Orientation Bias Detector (SOBDetector), a flexible c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ad93f6e799a883a7a64d322247fe09
https://pubmed.ncbi.nlm.nih.gov/34015811
https://pubmed.ncbi.nlm.nih.gov/34015811