Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marcin, Jakubiec"'
Autor:
Anna Rapacz, Marcin Jakubiec, Michał Abram, Jakub Jasiński, Karolina Chrzan, Małgorzata Góra, Anna Dziubina, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz-Adamczyk, Katarzyna Ciepiela, Elżbieta Pękala, Jolanta Obniska, Krzysztof Kamiński
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1532 (2024)
Background/Objectives: To address the unmet clinical needs in the treatment of epilepsy and pain, the continued development of more effective and safer anticonvulsants and analgesics is still necessary. Therefore, herein we report synthesis and antis
Externí odkaz:
https://doaj.org/article/a251ba8d7a9a4016a31cb678d9a9dcad
Autor:
Marcin Jakubiec, Michał Abram, Mirosław Zagaja, Marta Andres-Mach, Aleksandra Szewczyk, Gniewomir Latacz, Bartłomiej Szulczyk, Katarzyna Socała, Dorota Nieoczym, Piotr Wlaź, Cameron S. Metcalf, Karen Wilcox, Rafał M. Kamiński, Krzysztof Kamiński
Publikováno v:
Cells, Vol 11, Iss 12, p 1862 (2022)
In the present study, a focused combinatorial chemistry approach was applied to merge structural fragments of well-known TRPV1 antagonists with a potent anticonvulsant lead compound, KA-104, that was previously discovered by our group. Consequently,
Externí odkaz:
https://doaj.org/article/9d34a801f4aa4feab4747cefcea04a31
Autor:
Marcin Jakubiec
Publikováno v:
Scientific Papers of Silesian University of Technology. Organization and Management Series. 2022:229-242
Purpose: The aim of the article is to present the benefits of using selected Lean Management elements in the production process on the example of a company producing mechanical seals. Design/methodology/approach: The article is theoretical and empiri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::954dadd6821348253b9de4e77529f7a5
https://doi.org/10.29119/1641-3466.2022.158.15
https://doi.org/10.29119/1641-3466.2022.158.15
Autor:
Marta Andres-Mach, Mirosław Zagaja, Joanna Szala-Rycaj, Aleksandra Szewczyk, Michał Abram, Marcin Jakubiec, Katarzyna Ciepiela, Katarzyna Socała, Piotr Wlaź, Gniewomir Latacz, Nadia Khan, Krzysztof Kaminski
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8302
Epilepsy is a neurological disorder involving a number of disease syndromes with a complex etiology. A properly matched antiseizure drug (ASD) gives remission in up to 70% of patients. Nevertheless, there is still a group of about 30% of patients suf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53decfdbfce8268877ef7c4ee75db115
https://ruj.uj.edu.pl/xmlui/handle/item/311230
https://ruj.uj.edu.pl/xmlui/handle/item/311230
Autor:
Michał, Abram, Marcin, Jakubiec, Katelyn, Reeb, Mary Hongying, Cheng, Robin, Gedschold, Anna, Rapacz, Szczepan, Mogilski, Katarzyna, Socała, Dorota, Nieoczym, Małgorzata, Szafarz, Gniewomir, Latacz, Bartłomiej, Szulczyk, Justyna, Kalinowska-Tłuścik, Kinga, Gawel, Camila V, Esguerra, Elżbieta, Wyska, Christa E, Müller, Ivet, Bahar, Andréia C K, Fontana, Piotr, Wlaź, Rafał M, Kamiński, Krzysztof, Kamiński
Publikováno v:
Journal of medicinal chemistry. 65(17)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::338b23feb213a2d3ed90a9b7811d67f3
https://pubmed.ncbi.nlm.nih.gov/35984707
https://pubmed.ncbi.nlm.nih.gov/35984707
Autor:
Krzysztof Kamiński, Marcin Jakubiec, Mirosław Zagaja, Marta Andres-Mach, Szczepan Mogilski, Gniewomir Latacz
Publikováno v:
Proceedings, Vol 22, Iss 1, p 30 (2019)
Epilepsy is recognized as one of the most common neurological disorders with a high risk of drug resistance. Notably, about one-third of the patients with epilepsy are not responsive to pharmacological treatment. Thus, the search for new, more effect
Externí odkaz:
https://doaj.org/article/ebf5aee7fb024387a4563923bf079c1e
Publikováno v:
EUROPEAN RESEARCH STUDIES JOURNAL. :708-726
PURPOSE: The main concept of the work is to learn, understand, describe and explain the importance of leaders characterized by special moral competences giving them a rational direction to their behaviors and thus to the development of the socially r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb57f33c3e79d6267d57be7d219ddc93
https://doi.org/10.35808/ersj/2069
https://doi.org/10.35808/ersj/2069
Autor:
Elwira Brodnicka, Marcin Jakubiec
Publikováno v:
Research on Enterprise in Modern Economy Theory and Practice, Vol 2, Iss 17 (2016)
Minimizing the impact of operations on the environment is one of the most important strategic objectives of enterprises. These actions result from the implementation of the strategy CRS, which in relation to environmental policy is implemented in org
Externí odkaz:
https://doaj.org/article/f6bfeecc86dc41079a370fb29858e9cb
Autor:
Michał Abram, Marcin Jakubiec, Katelyn Reeb, Mary Hongying Cheng, Robin Gedschold, Anna Rapacz, Szczepan Mogilski, Katarzyna Socała, Dorota Nieoczym, Małgorzata Szafarz, Gniewomir Latacz, Bartłomiej Szulczyk, Justyna Kalinowska-Tłuścik, Kinga Gawel, Camila V. Esguerra, Elżbieta Wyska, Christa E. Müller, Ivet Bahar, Andréia C. K. Fontana, Piotr Wlaź, Rafał M. Kamiński, Krzysztof Kamiński
(R)-7 [(R)-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and PTZ-kindling. A remarkable separation between antiseizure activity and CN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9edda0a63b9b4c266dac589ff4f8da
https://ruj.uj.edu.pl/xmlui/handle/item/299969
https://ruj.uj.edu.pl/xmlui/handle/item/299969
Autor:
Marcin Jakubiec, Elwira Brodnicka
Publikováno v:
Research on Enterprise in Modern Economy Theory and Practice, Vol 1, Iss 16 (2016)
Following article concerns a topic of quality improvement realized by a concept of continuous improvement – Kaizen. The main goal of the article is to analyze of practical usage of Kaizen, in terms of elimination all waste and continuous improvemen
Externí odkaz:
https://doaj.org/article/07f44cc829524a27955155819af0092f