Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marcin, Łyszkiewicz"'
Autor:
Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/9e89d380ba524171be8ac6b2c5c274ad
Autor:
Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated i
Externí odkaz:
https://doaj.org/article/c1ccb1c3902a42deb7a8b59d19e9f6cb
Autor:
Yanxin Fan, Marta Murgia, Monika I. Linder, Yoko Mizoguchi, Cong Wang, Marcin Łyszkiewicz, Natalia Ziȩtara, Yanshan Liu, Stephanie Frenz, Gabriela Sciuccati, Armando Partida-Gaytan, Zahra Alizadeh, Nima Rezaei, Peter Rehling, Sven Dennerlein, Matthias Mann, Christoph Klein
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
The relevance of molecular mechanisms governing mitochondrial proteostasis to the differentiation and function of hematopoietic and immune cells is largely elusive. Through dissection of the network of proteins related to HCLS1-associated protein X-1
Externí odkaz:
https://doaj.org/article/48d4a94c9494431abcad847db209c4a5
Autor:
Marcin Łyszkiewicz, Natalia Ziętara, Laura Frey, Ulrich Pannicke, Marcel Stern, Yanshan Liu, Yanxin Fan, Jacek Puchałka, Sebastian Hollizeck, Ido Somekh, Meino Rohlfs, Tuğba Yilmaz, Ekrem Ünal, Musa Karakukcu, Türkan Patiroğlu, Christina Kellerer, Ebru Karasu, Karl-Walter Sykora, Atar Lev, Amos Simon, Raz Somech, Joachim Roesler, Manfred Hoenig, Oliver T. Keppler, Klaus Schwarz, Christoph Klein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
FCH domain only 1 (FCHO1) is a key molecule involved in clathrin-mediated endocytosis (CME). Here, the authors report homozygous FCHO1 mutations in individuals with variable T and B cell lymphopenia, which are associated with loss-of-function of FCHO
Externí odkaz:
https://doaj.org/article/74724d48da6d4ad88e09abfe678d8216
Publikováno v:
Immunology Letters. 247:1-12
T-cell development in the thymus is dependent on the continual colonization by bone-marrow derived progenitor cells. Once inside the thymus, progenitors undergo a series of well-defined differentiation events, including lineage commitment, somatic re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e11011e55cab3ab63669f973ef9f0d
https://doi.org/10.1016/j.imlet.2022.04.009
https://doi.org/10.1016/j.imlet.2022.04.009
Autor:
Marcin Łyszkiewicz, Samantha J Winter, Katrin Witzlau, Lisa Föhse, Rebecca Brownlie, Jacek Puchałka, Nikita A Verheyden, Heike Kunze-Schumacher, Esther Imelmann, Jonas Blume, Solaiman Raha, Takashi Sekiya, Akihiko Yoshimura, Jochen T Frueh, Evelyn Ullrich, Jochen Huehn, Siegfried Weiss, Maximiliano G Gutierrez, Immo Prinz, Rose Zamoyska, Natalia Ziętara, Andreas Krueger
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e2006716 (2019)
The interdependence of selective cues during development of regulatory T cells (Treg cells) in the thymus and their suppressive function remains incompletely understood. Here, we analyzed this interdependence by taking advantage of highly dynamic cha
Externí odkaz:
https://doaj.org/article/49acf38f9aa2422c892b9dbd30a0f152
Autor:
Marcin Łyszkiewicz, Daniel Kotlarz, Natalia Ziȩtara, Gudrun Brandes, Jana Diestelhorst, Silke Glage, Elias Hobeika, Michael Reth, Lukas A. Huber, Andreas Krueger, Christoph Klein
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
B-cell development and function depend on stage-specific signaling through the B-cell antigen receptor (BCR). Signaling and intracellular trafficking of the BCR are connected, but the molecular mechanisms of this link are incompletely understood. Her
Externí odkaz:
https://doaj.org/article/9323e58098774607b8426c3f25a2332c
Autor:
Marcin Łyszkiewicz, Natalia Ziętara, Laura Frey, Ulrich Pannicke, Marcel Stern, Yanshan Liu, Yanxin Fan, Jacek Puchałka, Sebastian Hollizeck, Ido Somekh, Meino Rohlfs, Tuğba Yilmaz, Ekrem Ünal, Musa Karakukcu, Türkan Patiroğlu, Christina Kellerer, Ebru Karasu, Karl-Walter Sykora, Atar Lev, Amos Simon, Raz Somech, Joachim Roesler, Manfred Hoenig, Oliver T. Keppler, Klaus Schwarz, Christoph Klein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/6a981817becc4e8ca162ede7a2b51a17
Autor:
Monika I. Linder, Yoko Mizoguchi, Sebastian Hesse, Gergely Csaba, Megumi Tatematsu, Marcin Łyszkiewicz, Natalia Ziȩtara, Tim Jeske, Maximilian Hastreiter, Meino Rohlfs, Yanshan Liu, Piotr Grabowski, Kaarin Ahomaa, Daniela Maier-Begandt, Marko Schwestka, Vahid Pazhakh, Abdulsalam I. Isiaku, Brenda Briones Miranda, Piers Blombery, Megumu K. Saito, Ejona Rusha, Zahra Alizadeh, Zahra Pourpak, Masao Kobayashi, Nima Rezaei, Ekrem Unal, Fabian Hauck, Micha Drukker, Barbara Walzog, Juri Rappsilber, Ralf Zimmer, Graham J. Lieschke, Christoph Klein
Publikováno v:
Linder, M I, Mizoguchi, Y, Hesse, S, Csaba, G, Tatematsu, M, Łyszkiewicz, M, Zietara, N, Jeske, T, Hastreiter, M, Rohlfs, M, Liu, Y, Grabowski, P, Ahomaa, K, Maier-Begandt, D, Schwestka, M, Pazhakh, V, Isiaku, A, Briones Miranda, B, Blombery, P, Saito, M K, Rusha, E, Alizadeh, Z, Pourpak, Z, Kobayashi, M, Rezaei, N, Unal, E, Hauck, F, Drukker, M, Walzog, B, Rappsilber, J, Zimmer, R, Lieschke, G J & Klein, C 2022, ' Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes ', Blood . https://doi.org/10.1182/blood.2022016783
Blood 141, 645-658 (2023)
Blood 141, 645-658 (2023)
SRPRA and SRP19 are novel genes affected in congenital neutropenia and essential for granule protein processing.Comparative proteomics in neutrophil granulocytesThe mechanisms of coordinated changes in proteome composition and their relevance for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01b87dd495a5f0fe7ae0494a3a2e55d
https://hdl.handle.net/20.500.11820/b6670f6f-3655-4127-adbb-e84d2b19f87d
https://hdl.handle.net/20.500.11820/b6670f6f-3655-4127-adbb-e84d2b19f87d
Autor:
Christoph Klein, Eckhard Wolf, Maik Dahlhoff, Florian Giesert, Wolfgang Wurst, Marlon R. Schneider, Benjamin Marquardt, Monika I. Linder, Raz Somech, Laura Frey, Yanshan Liu, Yoko Mizoguchi, Marcin Łyszkiewicz, Natalia Ziętara
Publikováno v:
Blood 137, 1932-1944 (2021)
Vacuolar protein sorting 45 homolog (VPS45), a member of the Sec1/Munc18 (SM) family, has been implicated in the regulation of endosomal trafficking. VPS45 deficiency in human patients results in congenital neutropenia, bone marrow fibrosis, and extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31de005a9c57b9297f69fdc8478467a8
https://doi.org/10.1182/blood.2020006871
https://doi.org/10.1182/blood.2020006871